VASODILATOR ELUTING MEDICAL DEVICES WITH A SPECIFIC POLYPHOSPHAZENE COATING AND METHODS FOR THEIR MANUFACTURE AND USE
    2.
    发明申请
    VASODILATOR ELUTING MEDICAL DEVICES WITH A SPECIFIC POLYPHOSPHAZENE COATING AND METHODS FOR THEIR MANUFACTURE AND USE 审中-公开
    具有特殊多磷酸涂层的血管加压器医用装置及其制造和使用方法

    公开(公告)号:US20080138792A1

    公开(公告)日:2008-06-12

    申请号:US11931021

    申请日:2007-10-31

    摘要: The present invention is directed to medical devices in which flow is channeled of blood and blood products for the purpose of effecting a chemical exchange to remove desired chemicals from the blood or blood products, and to impart nitric oxide, other smooth muscle relaxant compounds, or other desired chemicals to the blood or blood products to achieve vascular dilatation, reduce adverse reactions, reduce thrombosis, reduce red blood cell injuries, and improve blood handling capabilities. In the present invention, such chemical exchanges occur over semipermeable membranes associated with channeled flow of blood and blood products. Various embodiments of the present invention thus apply to the clinical settings for filters, cannulae, tubing, and blood handling components for dynamic blood handling, filtering, and processing devices including, but not limited to, cardiopulmonary bypass pumps, left ventricular assist devices, artificial hearts, ECMO devices, renal or hepatic hemodialysis systems, and hemofiltration systems.

    摘要翻译: 本发明涉及医疗装置,其中为了进行化学交换以从血液或血液制品中除去所需化学物质,以及赋予一氧化氮,其它平滑肌松弛剂化合物或血液和血液制品 其他需要化学物质的血液或血液制品实现血管扩张,减少不良反应,减少血栓形成,减少红细胞损伤,改善血液处理能力。 在本发明中,这种化学交换发生在与血液和血液制品的通道流动相关的半透膜上。 因此,本发明的各种实施例适用于用于动态血液处理,过滤和处理装置的过滤器,套管,管道和血液处理组件的临床设置,包括但不限于体外循环泵,左心室辅助装置,人造 心脏,ECMO装置,肾或肝血液透析系统和血液滤过系统。

    Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
    4.
    发明申请
    Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same 审中-公开
    用于治疗勃起功能障碍的可负载聚合物颗粒及其制备和使用方法

    公开(公告)号:US20080226723A1

    公开(公告)日:2008-09-18

    申请号:US11931685

    申请日:2007-10-31

    IPC分类号: A61K9/14 A61K9/00 A61K38/44

    CPC分类号: A61L27/34 C08L85/02

    摘要: Particles are provided for use in restorative procedures to treat erectile dysfunction. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be loaded to provide localized treatment with an active agent directed at restoration of normal penile erectile function and the treatment of erectile dysfunction. Moreover, such particles may be provided to a user with customized coloration or in various coded colors to indicate differing doses of active agent contained therein.

    摘要翻译: 提供颗粒用于治疗勃起功能障碍的恢复性手术。 颗粒包括聚[双(三氟乙氧基)磷腈]和/或其衍生物,其可以存在于整个颗粒中或颗粒的外涂层内。 颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。 可以加载这样的颗粒以提供针对恢复正常阴茎勃起功能的活性剂和勃起功能障碍的治疗的局部治疗。 此外,可以将这样的颗粒提供给具有定制着色的用户或以各种编码的颜色提供给用户以指示其中所含的不同剂量的活性剂。