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    Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
    1.
    发明授权
    Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same 有权
    用于临床应用中增强成像的可装载聚合物颗粒及其制备和使用方法

    公开(公告)号：US09114162B2

    公开(公告)日：2015-08-25

    申请号：US11877839

    申请日：2007-10-24

    申请人： Ulf Fritz ,  Olaf Fritz ,  Thomas A. Gordy ,  Jacques Blümmel ,  Alexander Küller ,  Gretchen B. Wojcik

    发明人： Ulf Fritz ,  Olaf Fritz ,  Thomas A. Gordy ,  Ronald Wojcik ,  Jacques Blümmel ,  Alexander Küller

    IPC分类号： A61K49/04

    CPC分类号： A61K51/1244 ,  A61K49/0419 ,  A61K49/1824 ,  A61K49/225

    摘要： Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Microspheres of the present invention may further be provided with physical and/or chemical enhancements within the particles' cores to enhance visualization of the embolized tissue using a variety of medical imaging modalities, including conventional radiography, fluoroscopy, tomography, computerized tomography, ultrasound, scintillation, magnetic resonance, or other imaging technologies.

    摘要翻译： 颗粒被提供用于治疗和/或诊断过程。 颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或颗粒的外涂层内。 颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。 这样的颗粒可以以特定的选定尺寸提供给使用者，以允许特定大小的血管的选择性栓塞或在特定临床应用中用活性成分剂局部治疗。 本发明的微球可以进一步提供颗粒内核内的物理和/或化学增强，以使用各种医学成像模式来增强栓塞组织的可视化，包括常规放射成像，荧光透视，层析成像，计算机断层扫描，超声，闪烁 ，磁共振或其他成像技术。

    LOADABLE POLYMERIC PARTICLES FOR BONE AUGMENTATION AND METHODS OF PREPARING AND USING THE SAME
    6.
    发明申请
    LOADABLE POLYMERIC PARTICLES FOR BONE AUGMENTATION AND METHODS OF PREPARING AND USING THE SAME 审中-公开
    用于骨骼补充的负载聚合物颗粒及其制备和使用方法

    公开(公告)号：US20090111763A1

    公开(公告)日：2009-04-30

    申请号：US11924642

    申请日：2007-10-26

    申请人： Ulf Fritz ,  Olaf Fritz ,  Thomas A. Gordy ,  Ronald Wojcik

    发明人： Ulf Fritz ,  Olaf Fritz ,  Thomas A. Gordy ,  Ronald Wojcik

    IPC分类号： A61K31/7052 ,  A61P19/08 ,  C08L85/02

    CPC分类号： C09D185/02 ,  A61K9/5031 ,  A61L27/34 ,  A61L2430/02 ,  C08F220/14 ,  C08F222/1006 ,  C08G79/025 ,  C08L33/04 ,  C08L33/14 ,  C08L2203/02 ,  C08L85/02

    摘要： Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided for placement within defects in bone within the body of a mammal to augment structural support and facilitate osteogenesis without causing adverse reactions therein. The hydrogel core may further be used as a delivery vehicle for therapeutic agents to treat or retard pathologic processes within the bone defect during healing.

    摘要翻译： 颗粒被提供用于治疗和/或诊断过程。 颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或颗粒的外涂层内。 颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。 可以提供这样的颗粒放置在哺乳动物身体内的骨缺损中，以增加结构支撑并促进成骨而不引起不良反应。 水凝胶核心还可用作治疗剂的治疗或治疗期间骨缺损内的病理过程的递送载体。

    Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
    8.
    发明申请
    Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same 审中-公开
    用于标记或掩蔽个体的可负载聚合物颗粒及其制备和使用方法

    公开(公告)号：US20090110730A1

    公开(公告)日：2009-04-30

    申请号：US11928772

    申请日：2007-10-30

    申请人： Ulf Fritz ,  Olaf Fritz ,  Thomas A. Gordy ,  Ronald Wojcik

    发明人： Ulf Fritz ,  Olaf Fritz ,  Thomas A. Gordy ,  Ronald Wojcik

    IPC分类号： A61K9/14 ,  A61K47/30 ,  A61P17/00 ,  G06K9/00 ,  A61K9/00

    CPC分类号： A61B5/411 ,  A01K11/00 ,  A61K9/1641 ,  A61K49/0089

    摘要： The present invention relates to the use of certain microspheres, nanospheres, and other structures to provide a method of marking or masking identifying marks in individual biological hosts. Biological hosts for the present invention may include humans, other animals, or plants. Such methods may be used to sense, signal, track, mark, or identify individual biological hosts. Microspheres, nanospheres, and other structures of the present invention may be implanted, injected, ingested, or attached to individual biological hosts. Microspheres, nanospheres, and other structures of the present invention comprise poly[bis(trifluoroethoxy)phosphazene] and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The microspheres, nanospheres, and other structures may also comprise a core having a hydrogel which may further comprise one or more dyes or other chromophoric agents covalently bound permanently to the hydrogel core material. The microspheres, nanospheres, and other structures and/or the hydrogel core may further comprise radio frequency or other electronic chips or nanochips, capable of transmitting and/or receiving electronic signals from external transmitters and/or receivers.

    摘要翻译： 本发明涉及使用某些微球，纳米球和其他结构来提供标记或掩蔽各个生物宿主中的识别标记的方法。 本发明的生物宿主可以包括人，其他动物或植物。 这样的方法可用于感测，信号，跟踪，标记或识别各个生物宿主。 本发明的微球，纳米球和其他结构可以植入，注射，摄取或附着于各个生物宿主。 本发明的微球，纳米球和其它结构包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或在颗粒的外涂层内。 微球，纳米球和其它结构还可以包含具有水凝胶的芯，其可以进一步包含与水凝胶芯材料永久结合共价结合的一种或多种染料或其它发色剂。 微球，纳米球和其他结构和/或水凝胶芯还可以包括能够从外部发射器和/或接收器发射和/或接收电子信号的射频或其他电子芯片或纳米芯片。

    Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
    9.
    发明申请
    Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same 审中-公开
    用于治疗勃起功能障碍的可负载聚合物颗粒及其制备和使用方法

    公开(公告)号：US20080226723A1

    公开(公告)日：2008-09-18

    申请号：US11931685

    申请日：2007-10-31

    申请人： Olaf Fritz ,  Ulf Fritz ,  Ronald Wojcik ,  Ralph E. Gaskins

    发明人： Olaf Fritz ,  Ulf Fritz ,  Ronald Wojcik ,  Ralph E. Gaskins

    IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K38/44

    CPC分类号： A61L27/34 ,  C08L85/02

    摘要： Particles are provided for use in restorative procedures to treat erectile dysfunction. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be loaded to provide localized treatment with an active agent directed at restoration of normal penile erectile function and the treatment of erectile dysfunction. Moreover, such particles may be provided to a user with customized coloration or in various coded colors to indicate differing doses of active agent contained therein.

    摘要翻译： 提供颗粒用于治疗勃起功能障碍的恢复性手术。 颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或颗粒的外涂层内。 颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。 可以加载这样的颗粒以提供针对恢复正常阴茎勃起功能的活性剂和勃起功能障碍的治疗的局部治疗。 此外，可以将这样的颗粒提供给具有定制着色的用户或以各种编码的颜色提供给用户以指示其中所含的不同剂量的活性剂。