-
1.发明授权Stereoisomers of benzonitrile derivatives, useful as cardiac arrhythmiac agents 失效苯并噻唑衍生物的立体异构体，有用的作为心脏抗坏血酸剂
公开(公告)号：US5055490A
公开(公告)日：1991-10-08
申请号：US539852
申请日：1990-06-18
IPC分类号： A61K31/275 , A61K31/10 , A61K31/13 , A61P9/06 , C07C205/30 , C07C205/34 , C07C315/04 , C07C317/00 , C07C317/02 , C07C317/28
CPC分类号： C07C317/28
摘要： 4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzonitrile,4-[3-[ethyl[3-((S*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzonitrile,4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy]-benzonitrile,4-[3-[ethyl[3-[((S*)-propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy]-benzonitrile andpharmaceutically acceptable salt thereof, processes for their preparation, as well as the use of said compounds for the preparation of medicaments with action against cardiac arrhythmias.
-
2.发明授权
公开(公告)号：US5155133A
公开(公告)日：1992-10-13
申请号：US643161
申请日：1991-01-18
IPC分类号： A61K31/275 , A61K20060101 , A61K31/10 , A61K31/13 , A61K31/54 , A61K31/55 , A61K31/554 , A61P9/06 , C07C255/53 , C07C255/54 , C07C255/56 , C07C255/58 , C07C315/02 , C07C315/04 , C07C317/02 , C07C317/18 , C07C317/26 , C07C317/28 , C07C317/32 , C07C317/44 , C07C319/20 , C07C323/02 , C07C323/13 , C07C323/25 , C07C323/26 , C07C323/29 , C07C323/32 , C07C323/36 , C07C323/41 , C07C323/58 , C07C323/62 , C07D20060101 , C07D207/08 , C07D207/12 , C07D211/18 , C07D211/24 , C07D223/04 , C07D223/06 , C07D279/00 , C07D279/12 , C07D281/06 , C07D295/00 , C07D295/04 , C07D295/08 , C07D295/22
CPC分类号： C07C323/25 , C07C317/32 , C07C323/32 , C07C323/41
摘要： A compound of the formula ##STR1## and when appropriate in the form of a racemic mixture or in the form of a stereoisomeric component and the pharmaceutically acceptable salts thereof, in which formulan is an integer 0, 1 or 2Y is [CH.sub.2 ].sub.m, CHOH, CHOCH.sub.3, CHNHR or CHF,m is an integer 0 or 1 andR is hydrogen, methyl or ethyl,Z is hydrogen or a saturated or unsaturated, straight or branched alkyl group containing 1-3 carbon atoms,A is a group ##STR2## wherein R.sub.a is a straight or branched hydroxyalkyl or an alkyl group containing 1-5 carbon atoms and optionally substituted by one or more fluoro atoms,R.sub.c is a saturated or unsaturated, straight or branched alkyl group containing 1-4 carbon atoms and optionally substituted by one or more fluoro atoms,R.sub.a' is the same as Ra and independently of R.sub.a",R.sub.a" is the same as Ra and independently of R.sub.a',p is an integer 0, 1 or 2,s is an integer 2, 3, 4, 5useful for the treatment of cardiac arrhythmia, pharmaceutical compositions containing such compounds as active ingredients, processes for preparation of such compounds as well as intermediates for their preparation.
摘要翻译： 式I的化合物，适当时为外消旋混合物形式或其立体异构体形式及其药学上可接受的盐，其中式n为整数0,1或2，Y为[CH 2 m，CHOH，CHOCH 3，CHNHR或CHF，m为整数0或1，R为氢，甲基或乙基，Z为氢或含有1-3个碳原子的饱和或不饱和的直链或支链烷基，A为 其中R a是直链或支链羟烷基或含有1-5个碳原子并任选被一个或多个氟原子取代的烷基，R c是含有1-4个碳原子的饱和或不饱和的直链或支链烷基 原子并且任选地被一个或多个氟原子取代，Ra'与Ra相同且独立于Ra“，Ra”与Ra相同且独立于Ra'，p是整数0,1或2，s 是用于治疗心律失常的整数2,3,4,5，含有s的药物组合物 这些化合物作为活性成分，制备这些化合物的方法以及其制备中间体。
-
3.发明授权
公开(公告)号：US5034411A
公开(公告)日：1991-07-23
申请号：US289630
申请日：1988-12-22
IPC分类号： A61K31/275 , A61K20060101 , A61K31/10 , A61K31/13 , A61K31/54 , A61K31/55 , A61K31/554 , A61P9/06 , C07C255/53 , C07C255/54 , C07C255/56 , C07C255/58 , C07C315/02 , C07C315/04 , C07C317/02 , C07C317/18 , C07C317/26 , C07C317/28 , C07C317/32 , C07C317/44 , C07C319/20 , C07C323/02 , C07C323/13 , C07C323/25 , C07C323/26 , C07C323/29 , C07C323/32 , C07C323/36 , C07C323/41 , C07C323/58 , C07C323/62 , C07D20060101 , C07D207/08 , C07D207/12 , C07D211/18 , C07D211/24 , C07D223/04 , C07D223/06 , C07D279/00 , C07D279/12 , C07D281/06 , C07D295/00 , C07D295/04 , C07D295/08 , C07D295/22
CPC分类号： C07C323/25 , C07C317/32 , C07C323/32 , C07C323/41
摘要： This application relates to novel 4 cyanophenyl derivatives which are useful for the treatment of cardiac arrhythmia and pharmaceutical compositions containing these compounds as the active ingredients.
-
4.发明授权Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases 失效苯氧基 - 羟丙基胺，其制备方法和治疗心血管疾病的方法和药物制剂
公开(公告)号：US4145442A
公开(公告)日：1979-03-20
申请号：US719345
申请日：1976-08-31
申请人： Peder B. Berntsson , Arne E. Brandstrom , Enar I. Carlsson , Stig A. I. Carlsson , Lars Ek , Benny R. Samuelsson , Sven E. Sjostrand , Gert C. Strandlund , Bengt A. H. Ablad
发明人： Peder B. Berntsson , Arne E. Brandstrom , Enar I. Carlsson , Stig A. I. Carlsson , Lars Ek , Benny R. Samuelsson , Sven E. Sjostrand , Gert C. Strandlund , Bengt A. H. Ablad
IPC分类号： A61K31/135 , C07C93/06
摘要： Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R.sup.1 is alkyl or hydroxyalkyl, R.sup.2 is alkoxyalkyl or alkylthioalkyl, and R.sup.3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed, as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.
摘要翻译： 具有通式为“IMAGE”的正对位取代的苯氧基 - 羟丙基胺及其药学上可接受的无毒的酸加成盐，其中R 1为烷基或羟烷基，R 2为烷氧基烷基或烷硫基烷基，R 3为卤素，烷基，烯基，炔基 ，烷氧基甲基或烷氧基，以及它们的制备方法。
-
-
-
搜索结果
4 条记录 (耗时 0.021 秒)
