公开(公告)号：US06630673B2

公开(公告)日：2003-10-07

申请号：US10036826

申请日：2001-12-21

申请人： Omar S. Khalil ,  Xiaomao Wu ,  Johannes Sake Kanger ,  Rene' Alexander Bolt ,  Shu-Jen Yeh ,  Charles F. Hanna ,  Frits Frans Maria de Mul

发明人： Omar S. Khalil ,  Xiaomao Wu ,  Johannes Sake Kanger ,  Rene' Alexander Bolt ,  Shu-Jen Yeh ,  Charles F. Hanna ,  Frits Frans Maria de Mul

IPC分类号： G01N2147

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043 ,  G01N21/49

摘要： Apparatus and method for non-invasively measuring at least one optical parameter of a sample, particularly a sample of tissue that comprises a plurality of layers. The at least one parameter can be used to determine the presence or concentration of an analyte of interest in the sample of tissue. The apparatus and method of the present invention (1) measure light that is substantially reflected, scattered, absorbed, or emitted from a shallower layer of the sample of tissue, (2) measure light that is substantially reflected, scattered, absorbed, or emitted from a deeper layer of the sample of tissue, (3) determine at least one optical parameter for each of these layers, and (4) account for the effect of the shallower layer on the at least one optical parameter of the deeper layer. Specifying the sampling depth allows determinations of the optical properties of a specific layer of the sample of the tissue, e.g., dermis, and decreases interference from other layers, e.g., stratum corneum and epidermis, in these determinations.

公开(公告)号：US06353226B1

公开(公告)日：2002-03-05

申请号：US09198094

申请日：1998-11-23

申请人： Omar S. Khalil ,  Xiaomao Wu ,  Johannes Sake Kanger ,  Rene′ Alexander Bolt ,  Shu-Jen Yeh ,  Charles F. Hanna ,  Frits Frans Maria de Mul

发明人： Omar S. Khalil ,  Xiaomao Wu ,  Johannes Sake Kanger ,  Rene′ Alexander Bolt ,  Shu-Jen Yeh ,  Charles F. Hanna ,  Frits Frans Maria de Mul

IPC分类号： A61B500

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043 ,  G01N21/49

摘要： Apparatus and method for non-invasively measuring at least one optical parameter of a sample, particularly a sample of tissue that comprises a plurality of layers. The at least one parameter can be used to determine the presence or concentration of an analyte of interest in the sample of tissue. The apparatus and method of the present invention (1) measure light that is substantially reflected, scattered, absorbed, or emitted from a shallower layer of the sample of tissue, (2) measure light that is substantially reflected, scattered, absorbed, or emitted from a deeper layer of the sample of tissue, (3) determine at least one optical parameter for each of these layers, and (4) account for the effect of the shallower layer on the at least one optical parameter of the deeper layer. Specifying the sampling depth allows determinations of the optical properties of a specific layer of the sample of the tissue, e.g., dermis, and decreases interference from other layers, e. g., stratum corneum and epidermis, in these determinations.

摘要翻译： 用于非侵入性地测量样品，特别是包括多个层的组织样品的至少一个光学参数的装置和方法。 可以使用至少一个参数来确定组织样品中感兴趣的分析物的存在或浓度。 本发明的装置和方法（1）测量从组织样本的较浅层基本反射，散射，吸收或发射的光，（2）测量基本上被反射，散射，吸收或发射的光 从组织样本的较深层，（3）确定这些层中的每一层的至少一个光学参数，以及（4）考虑较浅层对较深层的至少一个光学参数的影响。 指定采样深度允许确定组织样品（例如真皮）的特定层的光学性质，并减少来自其它层的干扰，例如， 在这些决定中，例如角质层和表皮。

公开(公告)号：US06635491B1

公开(公告)日：2003-10-21

申请号：US09627859

申请日：2000-07-28

申请人： Omar S. Khalil ,  Johannes Sake Kanger ,  Rene′ Alexander Bolt ,  Frits Frans Maria de Mul

发明人： Omar S. Khalil ,  Johannes Sake Kanger ,  Rene′ Alexander Bolt ,  Frits Frans Maria de Mul

IPC分类号： G01N3300

CPC分类号： A61B5/1455 ,  A61B5/14514 ,  A61B5/14532 ,  G01N21/31 ,  G01N21/314 ,  G01N21/359 ,  G01N21/49 ,  G01N2021/3133 ,  G01N2021/3155 ,  G01N2021/3174 ,  Y10T436/144444

摘要： A method for determining the concentration of an analyte in tissues. The method involves compensating for a change in the value of an optical property of the tissues, such as, for example, the scattering coefficient, resulting from a change in the hydration status of the tissues. The method comprises the steps of: (a) measuring at least one optical property of a tissue sample at at least one wavelength at an initial time; (b) calculating the absorption coefficient and the scattering coefficient of the tissue sample at the initial time; (c) repeating the measurement of the at least one optical property of the tissue sample at at least a later time at the at least one wavelength; (d) calculating the absorption coefficient and scattering coefficient of the tissue sample at at least the later time; (e) calculating the change in the value of the absorption coefficient at the at least one wavelength to indicate the change in the water content of the tissue sample and the change in the value of the scattering coefficient to indicate both the change in the water content of the tissue sample and the change in concentration of an analyte in the tissue sample; (f) correcting the value of the scattering coefficient to account for the effect of the change in the water content of the tissue sample; and (g) calculating the concentration of the analyte by means of the corrected value of the scattering coefficient.

摘要翻译： 确定组织中分析物浓度的方法。 该方法包括补偿组织的光学性质的变化值，例如由于组织的水合状态变化而产生的散射系数。 该方法包括以下步骤：（a）在初始时间测量至少一种波长的组织样品的至少一种光学性质;（b）计算初始时间组织样品的吸收系数和散射系数; （c）至少在稍后时间至少一个波长处重复所述组织样品的至少一种光学性质的测量;（d）至少在稍后时间计算组织样品的吸收系数和散射系数 ;（e）计算在至少一个波长处的吸收系数的值的变化，以指示组织样品的水含量的变化和散射系数的值的变化，以指示水的变化 组织样品的含量和组织样品中分析物的浓度变化;（f）校正散射系数的值，以考虑到水分含量变化的影响 组织样品; 和（g）通过散射系数的校正值计算分析物的浓度。