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公开(公告)号：US20120217385A1
公开(公告)日：2012-08-30
申请号：US13465408
申请日：2012-05-07
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An example optic module verification device for use in periodic normalization of a testing machine used to test samples in wells is disclosed. The example testing machine includes a plurality of photon counters that each count photons emitted from different wells. The example verification device includes a plurality of verification wells located so as to each be associated with one of the photon counters when used in the testing machine. The example device also includes a photon emitter in each verification well, each photon emitter including a C14 source, a scintillator adjacent the C14 source, and a filter over the scintillator. The example photon emitters each have a determined initial base value for emitted photons, and each photon emitter is positioned in its verification well to emit photons through the filter to the associated photon counter when used in the testing machine.
摘要翻译： 公开了一种用于在井中测试样品的测试机的周期性归一化中使用的示例性光学模块验证装置。 示例性测试机器包括多个光子计数器，每个光子计数器计数从不同孔发射的光子。 示例性验证装置包括多个验证孔，其位于当在测试机器中使用时各自与光子计数器中的一个相关联。 示例性装置还包括每个验证井中的光子发射器，每个光子发射器包括C14源，与C14源相邻的闪烁体和闪烁体上的滤光器。 示例性光子发射器各自具有用于发射光子的确定的初始基值，并且当在测试机中使用时，每个光子发射器位于其验证井中，以将光子通过滤光器发射到相关联的光子计数器。
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公开(公告)号：US07858924B2
公开(公告)日：2010-12-28
申请号：US11637314
申请日：2006-12-12
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An optic module verification device for normalizing between X photon counters, including a verification tray with X verification wells and a modular photon emitter in each verification well. Each photon emitter includes a spring, a Beta source disk, a scintillator disk adjacent the Beta source disk, and a neutral density filter over the scintillator disk, all of which are encapsulated in a cylindrical chamber with the filter adjacent an opening on one end of the chamber and the spring biasing the Beta source disk and the scintillator disk toward the opening. The device is periodically used for normalization, and may be updated when emitted photons fall below a desired level by replacing the scintillator disk and then determining a new normalized reference values for each photon emitter.
摘要翻译： 用于在X光子计数器之间进行归一化的光学模块验证装置，包括具有X个验证孔的验证盘和每个验证井中的模块化光子发射器。 每个光子发射器包括弹簧，β源盘，与β源盘相邻的闪烁体盘，以及在闪烁体盘上的中性密度滤光片，所有这些都被封装在圆柱形腔室中，过滤器邻近一端的开口 腔室和弹簧将Beta源盘和闪烁体盘偏置到开口。 周期性地使用该装置进行归一化，并且当发射的光子通过替换闪烁体盘然后确定每个光子发射器的新的归一化参考值而降低到期望的水平以下时，可以更新该装置。
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3.发明授权Method for optical measurements of tissue to determine disease state or concentration of an analyte 有权用于光学测量组织以确定分析物的疾病状态或浓度的方法公开(公告)号：US07167734B2
公开(公告)日：2007-01-23
申请号：US09834440
申请日：2001-04-13
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B5/7264
摘要： A method for collecting optical data at two morphologically similar, substantially non-overlapping, and preferably adjacent, areas on the surface of a tissue, while the temperature in each area is being maintained or modulated according to a temperature program. The optical data obtained are inserted into a mathematical relationship, e.g., an algorithm, that can be used to predict a disease state (such as the diabetes mellitus disease state) or the concentration of an analyte for indicating a physical condition (such as blood glucose level). This invention can be used to differentiate between disease status, such as, for example, diabetic and non-diabetic. The method involves the generation of a calibration (or training) set that utilizes the relationship between optical signals emanating from the skin under different thermal stimuli and disease status, e.g., diabetic status, established clinically. This calibration set can be used to predict the disease state of other subjects. Structural changes, as well as circulatory changes, due to a disease state are determined at two morphologically similar, but substantially non-overlapping areas on the surface of human tissue, e.g., the skin of a forearm, with each area being subjected to different temperature modulation programs. In addition to determination of a disease state, this invention can also be used to determine the concentration of an analyte in the tissues. This invention also provides an apparatus for the determination of a disease state, such as diabetes, or concentration of an analyte, such as blood glucose level, by the method of this invention.
摘要翻译： 一种用于在组织表面上的两个形态上类似的，基本上不重叠的，优选相邻的区域收集光学数据的方法，同时根据温度程序维持或调节每个区域中的温度。 所获得的光学数据被插入到数学关系中，例如算法，其可用于预测疾病状态（例如糖尿病状态）或用于指示身体状况的分析物的浓度（例如血糖 水平）。 本发明可用于区分疾病状况，例如糖尿病和非糖尿病。 该方法包括产生校准（或训练）组，其利用在不同热刺激下发生的光学信号与疾病状态（例如临床确立的糖尿病状态）之间的关系。 该校准集可用于预测其他受试者的疾病状态。 由于疾病状态引起的结构变化以及循环变化在人组织表面上的两个形态相似但基本上非重叠的区域确定，例如前臂的皮肤，每个区域经受不同的温度 调制程序。 除了确定疾病状态之外，本发明还可以用于确定组织中分析物的浓度。 本发明还提供了一种用于通过本发明的方法测定疾病状态的装置，例如糖尿病或分析物的浓度，例如血糖水平。
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公开(公告)号：USD332834S
公开(公告)日：1993-01-26
申请号：US570565
申请日：1990-08-21
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公开(公告)号：US5089424A
公开(公告)日：1992-02-18
申请号：US425643
申请日：1989-10-23
申请人： Omar S. Khalil , Thomas F. Zurek , Kevin R. Genger , Curtis J. Pepe , Yi-Her Jou , Stephen M. Cotter
发明人： Omar S. Khalil , Thomas F. Zurek , Kevin R. Genger , Curtis J. Pepe , Yi-Her Jou , Stephen M. Cotter
IPC分类号： G01N21/76 , G01N33/52 , G01N33/543 , G01N33/576
CPC分类号： G01N33/54346 , G01N33/521 , G01N33/525 , G01N33/54366 , G01N33/54386 , G01N33/5764
摘要： Apparatus and method for performing a chemiluminescence assay involving the immobilization of a chemiluminescent reaction complex to a solid, porous element. The solid, porous element is preferably treated to provide an immobilizing interaction with the chemiluminescent reaction complex wherein the chemiluminescent reaction complex is thereby immobilized to the solid, porous element. The activating and reading of the chemiluminescent reaction are separately performed by evenly distributing a concentrated chemiluminescent activating solution to form a puddle on the surface of the porous element to which the chemiluminescent reaction complex is immobilized.
摘要翻译： 用于进行化学发光测定的装置和方法，涉及将化学发光反应复合物固定在固体多孔元件上。 优选处理固体多孔元件以提供与化学发光反应复合物的固定相互作用，其中化学发光反应复合物由此固定在固体多孔元件上。 化学发光反应的激活和读取分别通过均匀分布浓缩的化学发光活化溶液在化学发光反应复合物固定的多孔元件的表面上形成一个水坑。
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公开(公告)号：US5006309A
公开(公告)日：1991-04-09
申请号：US184726
申请日：1988-04-22
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： G01N33/54366 , B01L3/5023 , B01L2200/027 , B01L2300/0809 , B01L2400/0406 , B01L2400/049 , Y10T436/255 , Y10T436/2575
摘要： A disposable device suitable for performing automated solid-state diagnostic assays which employs microparticles to complex an analyte and where the microparticle complex becomes retained and immobilized on a fibrous matrix such that the presence of analyte on the microparticles can be detected by an optical device. A device is disclosed having a shallow sample well for receiving a sample and reagents for forming a reaction mixture, a read well having (a) an entrance port and wash receiving structure for receiving a quantity of sample and assay reagents, (b) a fibrous matrix for retaining and immobilizing microparticle/analyte complexes for detection, the fibrous matrix positioned below the wash receiving structure, and having an average spatial separation of fibers greater than the average diameter of the microparticles and (c) a structure below the fibrous matrix for assisting the flow of sample and assay reagents through the fibrous matrix, such as an absorbent material or vacuum below the fibrous matrix and a passage means communicating between the shallow sample well and the read well where the sample and reaction mixtures can be transferred and washed from the shallow sample well into the read well without being contacted by any apparatus.
摘要翻译： 一种适用于执行自动化固态诊断测定的一次性装置，其使用微粒来复合分析物，并且其中微粒复合物保留并固定在纤维基质上，使得微粒上的分析物的存在可以通过光学装置检测。 公开了一种装置，其具有用于接收样品的浅样品阱和用于形成反应混合物的试剂，读数井具有（a）用于接收一定量的样品和测定试剂的入口和洗涤接收结构，（b）纤维 用于保持和固定用于检测的微粒/分析物复合物的基质，所述纤维基质位于洗涤接收结构下方，并且具有大于微粒平均直径的纤维的平均空间分离，和（c）纤维基质下面的结构用于辅助 通过纤维基质（例如吸收材料或纤维基质下方的真空）的样品和测定试剂的流动以及在浅样品阱和读数井之间连通的通道装置，其中样品和反应混合物可以从 浅样品很好地进入读取井，而不被任何装置接触。
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公开(公告)号：US08368009B2
公开(公告)日：2013-02-05
申请号：US13465408
申请日：2012-05-07
IPC分类号： G12B13/00
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An example optic module verification device for use in periodic normalization of a testing machine used to test samples in wells is disclosed. The example testing machine includes a plurality of photon counters that each count photons emitted from different wells. The example verification device includes a plurality of verification wells located so as to each be associated with one of the photon counters when used in the testing machine. The example device also includes a photon emitter in each verification well, each photon emitter including a C14 source, a scintillator adjacent the C14 source, and a filter over the scintillator. The example photon emitters each have a determined initial base value for emitted photons, and each photon emitter is positioned in its verification well to emit photons through the filter to the associated photon counter when used in the testing machine.
摘要翻译： 公开了一种用于在井中测试样品的测试机的周期性归一化中使用的示例性光学模块验证装置。 示例性测试机器包括多个光子计数器，每个光子计数器计数从不同孔发射的光子。 示例性验证装置包括多个验证孔，其位于当在测试机器中使用时各自与光子计数器中的一个相关联。 示例性装置还包括每个验证井中的光子发射器，每个光子发射器包括C14源，与C14源相邻的闪烁体和闪烁体上的滤光器。 示例性光子发射器各自具有用于发射光子的确定的初始基值，并且当在测试机中使用时，每个光子发射器位于其验证井中，以将光子通过滤光器发射到相关联的光子计数器。
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8.发明授权Method for noninvasive measurement of glucose and apparatus for noninvasive measurement of glucose 有权用于无创测量葡萄糖的方法和用于无创测量葡萄糖的装置公开(公告)号：US08315681B2
公开(公告)日：2012-11-20
申请号：US12418899
申请日：2009-04-06
申请人： Shoichi Kanayama , Omar S. Khalil , Tzyy-Wen Jeng , Shu-Jen Yeh
发明人： Shoichi Kanayama , Omar S. Khalil , Tzyy-Wen Jeng , Shu-Jen Yeh
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/0053 , A61B5/14532 , A61B5/1491 , A61B5/1495 , A61B5/6824 , A61B5/6843
摘要： A method for noninvasive measurement of glucose in a tissue of a subject, including the steps of bringing an adaptation device, which has a shape similar to a measurement probe, into contact with a skin part of a subject for stretching the skin part of the subject under a pressure that is higher than a pressure per unit area applied by the measurement probe during the noninvasive measurement, maintaining the contact for a predetermined period of time followed by relieving the contact, bringing the measurement probe into contact with the stretched skin part of the subject for the noninvasive measurement, collecting signals emitted from the subject, and estimating a glucose concentration based on the collected signals.
摘要翻译： 一种用于对受试者的组织中的葡萄糖进行非侵入性测量的方法，包括以下步骤：将具有与测量探针类似的形状的适应装置与受试者的皮肤部分接触以拉伸受试者的皮肤部分 在非侵入性测量期间高于测量探针施加的每单位面积的压力的压力下，将接触保持预定的时间段，然后释放接触，使测量探针与被拉伸的皮肤部分接触 主观无创测量，收集从受试者发射的信号，并根据收集的信号估计葡萄糖浓度。
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公开(公告)号：US06662030B2
公开(公告)日：2003-12-09
申请号：US09080470
申请日：1998-05-18
申请人： Omar S. Khalil , Frits F. M. de Mul , Charles F. Hanna , Arnold F. Stalder , Shu-jen Yeh , Xiaomao Wu , Michael G. Lowery , Johannes S. Kanger , René A. Bolt
发明人： Omar S. Khalil , Frits F. M. de Mul , Charles F. Hanna , Arnold F. Stalder , Shu-jen Yeh , Xiaomao Wu , Michael G. Lowery , Johannes S. Kanger , René A. Bolt
IPC分类号： A61B500
CPC分类号： A61B5/1491 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/6824 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/4795
摘要： Devices and methods for non-invasively measuring at least one parameter of a sample, such as the presence or concentration of an analyte, in a body part wherein the temperature is controlled. The present invention measures light that is reflected, scattered, absorbed, or emitted by the sample from an average sampling depth, dav, that is confined within a temperature controlled region in the tissue. This average sampling depth is preferably less than 2 mm, and more preferably less than 1 mm. Confining the sampling depth into the tissue is achieved by appropriate selection of the separation between the source and the detector and the illumination wavelengths. In another aspect, the invention involves a method and apparatus for non-invasively measuring at least one parameter of a body part with temperature stepping. In another aspect, the invention involves a method and apparatus for non-invasively measuring at least one parameter of a body part with temperature modulation. In another aspect, the invention provides an improved method of measuring at least one parameter of a tissue sample comprising the steps of: (a) lowering the temperature of said tissue sample to a temperature that is lower than the normal physiological temperature of the body; and (b) determining at least one optical property of said tissue sample.
摘要翻译： 用于非侵入性地测量样品的至少一个参数（例如分析物的存在或浓度）在其中控制温度的身体部位中的装置和方法。 本发明测量被从组织中的温度控制区域内限定的平均采样深度dav反射，散射，吸收或发射的光。 该平均采样深度优选小于2mm，更优选小于1mm。 通过适当选择源和检测器之间的距离以及照明波长来实现将采样深度限制在组织中。 在另一方面，本发明涉及一种用于非侵入性地测量具有温度步进的身体部位的至少一个参数的方法和装置。 在另一方面，本发明涉及一种用于通过温度调制非侵入性地测量身体部位的至少一个参数的方法和装置。 另一方面，本发明提供了一种测量组织样本的至少一个参数的改进方法，包括以下步骤：（a）将所述组织样本的温度降低到低于身体的正常生理温度的温度; 和（b）确定所述组织样品的至少一种光学性质。
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10.发明授权公开(公告)号：US06630673B2
公开(公告)日：2003-10-07
申请号：US10036826
申请日：2001-12-21
申请人： Omar S. Khalil , Xiaomao Wu , Johannes Sake Kanger , Rene' Alexander Bolt , Shu-Jen Yeh , Charles F. Hanna , Frits Frans Maria de Mul
发明人： Omar S. Khalil , Xiaomao Wu , Johannes Sake Kanger , Rene' Alexander Bolt , Shu-Jen Yeh , Charles F. Hanna , Frits Frans Maria de Mul
IPC分类号： G01N2147
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/49
摘要： Apparatus and method for non-invasively measuring at least one optical parameter of a sample, particularly a sample of tissue that comprises a plurality of layers. The at least one parameter can be used to determine the presence or concentration of an analyte of interest in the sample of tissue. The apparatus and method of the present invention (1) measure light that is substantially reflected, scattered, absorbed, or emitted from a shallower layer of the sample of tissue, (2) measure light that is substantially reflected, scattered, absorbed, or emitted from a deeper layer of the sample of tissue, (3) determine at least one optical parameter for each of these layers, and (4) account for the effect of the shallower layer on the at least one optical parameter of the deeper layer. Specifying the sampling depth allows determinations of the optical properties of a specific layer of the sample of the tissue, e.g., dermis, and decreases interference from other layers, e.g., stratum corneum and epidermis, in these determinations.
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