公开(公告)号：US09133150B2

公开(公告)日：2015-09-15

申请号：US13951720

申请日：2013-07-26

申请人： Orbital ATK, Inc.

发明人： Mark D. Bednarski ,  Susan Knox ,  Louis F. Cannizzo ,  Kirstin F. Warner ,  Robert B. Wardle ,  Stephen P. Velarde ,  Shoucheng Ning

IPC分类号： C07D307/02 ,  C07D305/00 ,  C07D407/00 ,  C07D493/00 ,  A01N43/02 ,  A61K31/335 ,  C07D303/22 ,  A61K31/21 ,  A61K31/336 ,  A61K31/38 ,  A61K31/395 ,  A61K45/06

CPC分类号： C07D303/22 ,  A61K31/21 ,  A61K31/336 ,  A61K31/38 ,  A61K31/395 ,  A61K45/06

摘要： The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

摘要翻译： 本发明提供O-硝基化合物，O-硝基化合物的药物组合物和使用O-硝基化合物和/或其药物组合物的方法来治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管 疾病和自身免疫性疾病。

公开(公告)号：US09650307B2

公开(公告)日：2017-05-16

申请号：US13804148

申请日：2013-03-14

申请人： Orbital ATK, Inc.

发明人： Stephen P. Velarde ,  Harold E. Johnston

IPC分类号： C06B25/34 ,  C06B25/00 ,  C06B21/00

CPC分类号： C06B25/34 ,  C06B21/00 ,  C06B21/005 ,  C06B25/00

摘要： A method of producing DEMN eutectic comprises reacting a reactant mixture comprising ethylenediamine and diethylenetriamine with aqueous nitric acid to form a reaction mixture comprising diethylentriamine trinitrate and ethylenediamine dinitrate. The reaction mixture is combined with methylnitroguanidine and nitroguanidine to form an aqueous slurry. Water is removed from the aqueous slurry. A method of producing an energetic composition, and a system for producing DEMN eutectic are also described.

公开(公告)号：US20170233307A1

公开(公告)日：2017-08-17

申请号：US15582954

申请日：2017-05-01

申请人： Orbital ATK, Inc.

发明人： Stephen P. Velarde ,  Harold E. Johnston

IPC分类号： C06B25/34 ,  C06B21/00

CPC分类号： C06B25/34 ,  C06B21/00 ,  C06B21/005 ,  C06B25/00

摘要： A method of producing DEMN eutectic comprises reacting a reactant mixture comprising ethylenediamine and diethylenetriamine with aqueous nitric acid to form a reaction mixture comprising diethylentriamine trinitrate and ethylenediamine dinitrate. The reaction mixture is combined with methylnitroguanidine and nitroguanidine to form an aqueous slurry. Water is removed from the aqueous slurry. A method of producing an energetic composition, and a system for producing DEMN eutectic are also described.