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公开(公告)号：US06433149B1
公开(公告)日：2002-08-13
申请号：US09305927
申请日：1999-05-05
IPC分类号： A61M138
CPC分类号： C07K14/705 , A61K38/00 , Y10S530/81 , Y10S530/828
摘要： Agents for inhibiting cancer metastasis are provided. The methods comprise administering to a patient an antimetastatic agent that comprises one or more of: (a) a peptide sequence that is at least 50% identical to an OB-cadherin CAR sequence; (b) a non-peptide mimetic of an OB-cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds an OB-cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises an OB-cadherin CAR sequence or analogue thereof.
摘要翻译： 提供了抑制癌症转移的药剂。 所述方法包括向患者施用抗转移剂，其包含以下一种或多种：（a）与OB-钙粘着蛋白CAR序列至少50％相同的肽序列; （b）OB-钙粘蛋白CAR序列的非肽模拟物; （c）特异性结合OB-钙粘着素CAR序列的物质，如抗体或其抗原结合片段; 和/或（d）编码包含OB-钙粘蛋白CAR序列或其类似物的多肽的多核苷酸。
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2.发明授权公开(公告)号：US07481999B2
公开(公告)日：2009-01-27
申请号：US11003150
申请日：2004-12-03
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K7/06 , A61K38/00 , C07K14/705
摘要： Compositions and methods for modulating OB-cadherin-mediated functions are provided. The compositions and methods employ OB-cadherin modulating agents which generally comprise one or more of: (a) a peptide sequence that is at least 50% identical to an OB-cadherin CAR sequence; (b) a non-peptide mimetic of an OB-cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds an OB-cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises an OB-cadherin CAR sequence or analogue thereof.
摘要翻译： 提供了调节OB-钙粘蛋白介导的功能的组合物和方法。 组合物和方法使用通常包含以下一种或多种的OB-钙粘蛋白调节剂：（a）与OB-钙粘着蛋白CAR序列至少50％相同的肽序列; （b）OB-钙粘蛋白CAR序列的非肽模拟物; （c）特异性结合OB-钙粘着素CAR序列的物质，如抗体或其抗原结合片段; 和/或（d）编码包含OB-钙粘蛋白CAR序列或其类似物的多肽的多核苷酸。
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公开(公告)号：US06682901B2
公开(公告)日：2004-01-27
申请号：US09305928
申请日：1999-05-05
IPC分类号： G01N33574
CPC分类号： C07K14/705 , A61K38/00 , Y10S977/91 , Y10S977/915
摘要： Methods for diagnosing cancer, such as prostate, ovarian or breast cancer, as well as leukemia, are provided. Such methods may employ binding agents, such as antibodies or CAR sequences of OB-cadherin or N-cadherin, that specifically bind to OB-cadherin or N-cadherin, or polynucleotides that hybridize to a polynucleotide encoding OB-cadherin or N-cadherin. Also provided are methods for monitoring the progression of a cancer and to evaluate the metastatic potential of a cancer.
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公开(公告)号：US06680175B2
公开(公告)日：2004-01-20
申请号：US09234395
申请日：1999-01-20
IPC分类号： G01N33574
CPC分类号： C07K14/705 , A61K38/00 , Y10S977/91 , Y10S977/915
摘要： Methods for diagnosing cancer, such as prostate, ovarian or breast cancer, as well as leukemia, are provided. Such methods may employ binding agents, such as antibodies or CAR sequences of OB-cadherin or N-cadherin, that specifically bind to OB-cadherin or N-cadherin, or polynucleotides that hybridize to a polynucleotide encoding OB-cadherin or N-cadherin. Also provided are methods for monitoring the progression of a cancer and to evaluate the metastatic potential of a cancer.
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公开(公告)号：US06593297B2
公开(公告)日：2003-07-15
申请号：US09264516
申请日：1999-03-08
IPC分类号： A61K31395
CPC分类号： C07K14/705 , A61K38/00 , Y10S977/91 , Y10S977/915
摘要： Agents for inhibiting cancer metastasis are provided. The methods comprise administering to a patient an antimetastatic agent that comprises one or more of: (a) a peptide sequence that is at least 50% identical to an OB-cadherin CAR sequence; (b) a non-peptide mimetic of an OB-cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds an OB-cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises an OB-cadherin CAR sequence or analogue thereof.
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6.发明授权公开(公告)号：US06638911B1
公开(公告)日：2003-10-28
申请号：US09535852
申请日：2000-03-27
IPC分类号： A61K3808
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/1008 , C07K5/101 , C07K7/06 , C07K14/705 , C07K2319/00 , Y10S977/805
摘要： Modulating agents for inhibiting or enhancing desmosomal cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: (a) a peptide sequence that is at least 50% identical to a desmosomal cadherin CAR sequence; (b) a non-peptide mimetic of a desmosomal cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds a desmosomal cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises a desmosomal cadherin CAR sequence or analogue thereof. Methods for using such modulating agents for modulating desmosomal cadherin-mediated cell adhesion in a variety of contexts are also provided.
摘要翻译： 提供了用于抑制或增强脱颗粒钙粘蛋白介导的细胞粘附的调节剂。 调节剂包含以下一种或多种：（a）与脱氨基体钙粘蛋白CAR序列至少50％相同的肽序列; （b）脱氨基体钙粘蛋白CAR序列的非肽模拟物; （c）特异性结合脱氨基体钙粘蛋白CAR序列的物质，如抗体或其抗原结合片段; 和/或（d）编码包含脱氨基体钙粘蛋白CAR序列或其类似物的多肽的多核苷酸。 还提供了在各种情况下使用这种调节剂调节溶酶体钙粘蛋白介导的细胞粘附的方法。
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7.发明授权Compounds and methods for modulating nonclassical cadherin-mediated functions 失效调节非经典钙粘蛋白介导功能的化合物和方法公开(公告)号：US06962969B2
公开(公告)日：2005-11-08
申请号：US10006869
申请日：2001-12-03
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P3/04 , A61P15/00 , A61P25/00 , A61P35/00 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , A61K38/12 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00 , Y10S977/91
摘要： Modulating agents for inhibiting or enhancing nonclassical cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: (a) a peptide sequence that is at least 50% identical to a nonclassical cadherin CAR sequence; (b) a non-peptide mimetic of a nonclassical cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds a nonclassical cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises a nonclassical cadherin CAR sequence or analogue thereof. Methods for using such modulating agents for modulating nonclassical cadherin-mediated cell adhesion in a variety of contexts are also provided.
摘要翻译： 提供了用于抑制或增强非经典钙粘蛋白介导的细胞粘附的调节剂。 调节剂包含以下一种或多种：（a）与非经典钙粘蛋白CAR序列至少50％相同的肽序列; （b）非经典钙粘素CAR序列的非肽模拟物; （c）特异性结合非经典钙粘蛋白CAR序列的物质，如抗体或其抗原结合片段; 和/或（d）编码包含非经典钙粘蛋白CAR序列或其类似物的多肽的多核苷酸。 还提供了在各种情况下使用这种调节剂调节非经典钙粘蛋白介导的细胞粘附的方法。
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公开(公告)号：US06830894B1
公开(公告)日：2004-12-14
申请号：US09434355
申请日：1999-11-03
IPC分类号： G01N33567
CPC分类号： C07K14/705 , A61K38/00
摘要： Methods for using modulating agents to enhance or inhibit claudin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase blood/brain barrier permeability. The modulating agents comprise at least one claudin cell adhesion recognition sequence or an antibody or fragment thereof that specifically binds the claudin cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
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9.发明授权Antibody that specifically binds to the cadherin-5 cell adhesion recognition sequence 失效特异性结合钙粘着蛋白-5细胞粘附识别序列的抗体公开(公告)号：US06569996B1
公开(公告)日：2003-05-27
申请号：US09839542
申请日：2001-04-20
IPC分类号： A61K3942
CPC分类号： C07K14/705 , A61K38/00 , Y10S977/91
摘要： Modulating agents for inhibiting or enhancing nonclassical cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: (a) a peptide sequence that is at least 50% identical to a nonclassical cadherin CAR sequence; (b) a non-peptide mimetic of a nonclassical cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds a nonclassical cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises a nonclassical cadherin CAR sequence or analogue thereof. Methods for using such modulating agents for modulating nonclassical cadherin-mediated cell adhesion in a variety of contexts are also provided.
摘要翻译： 提供了用于抑制或增强非经典钙粘蛋白介导的细胞粘附的调节剂。 调节剂包含以下一种或多种：（a）与非经典钙粘蛋白CAR序列至少50％相同的肽序列; （b）非经典钙粘素CAR序列的非肽模拟物; （c）特异性结合非经典钙粘蛋白CAR序列的物质，如抗体或其抗原结合片段; 和/或（d）编码包含非经典钙粘蛋白CAR序列或其类似物的多肽的多核苷酸。 还提供了在各种情况下使用这种调节剂调节非经典钙粘蛋白介导的细胞粘附的方法。
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10.发明授权公开(公告)号：US06472367B1
公开(公告)日：2002-10-29
申请号：US09073040
申请日：1998-05-05
IPC分类号： A61K3808
CPC分类号： C07K14/705 , A61K38/00 , Y10S977/91
摘要： Modulating agents for inhibiting or enhancing OB-cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: (a) an OB-cadherin CAR sequence; (b) a peptide analogue or peptidomimetic thereof; (c) an antibody or antigen-binding fragment thereof that specifically binds an OB-cadherin CAR sequence; and/or (d) a polynucleotide encoding any of the foregoing peptide sequences. Methods for using such modulating agents for modulating OB-cadherin-mediated cell adhesion in a variety of contexts are also provided.
摘要翻译： 提供了抑制或增强OB-钙粘蛋白介导的细胞粘附的调节剂。 调节剂包含以下一种或多种：（a）OB-钙粘蛋白CAR序列; （b）肽类似物或肽模拟物; （c）特异性结合OB-钙粘着素CAR序列的抗体或其抗原结合片段; 和/或（d）编码任何上述肽序列的多核苷酸。 还提供了在各种情况下使用这种调节剂调节OB-钙粘蛋白介导的细胞粘附的方法。
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