公开(公告)号：US20210275578A1

公开(公告)日：2021-09-09

申请号：US17236891

申请日：2021-04-21

Applicant: OSAKA UNIVERSITY

Inventor： Hikaru KOBAYASHI ,  Yuki KOBAYASHI ,  Ryoichi IMAMURA ,  Norio NONOMURA

IPC: A61K33/00 ,  A61P13/12 ,  A61K9/00 ,  A61K9/16

Abstract: One drug (solid preparation) 100 of the present invention is a drug for a disease of kidney that contains a silicon fine particle, an aggregate of the silicon fine particles, or a crystal grain of silicon having a hydrogen-generating ability. Hydrogen generated from the silicon fine particle in the drug can contribute to the prevention and/or treatment of the kidney disease.

公开(公告)号：US20200179439A1

公开(公告)日：2020-06-11

申请号：US16633807

申请日：2018-07-04

Applicant: OSAKA UNIVERSITY

Inventor： Hikaru KOBAYASHI ,  Yuki KOBAYASHI ,  Ryoichi IMAMURA ,  Norio NONOMURA

IPC: A61K33/00 ,  A61K9/16 ,  A61K9/00 ,  A61P13/12

Abstract: One drug (solid preparation) 100 of the present invention is a drug for a disease of kidney that contains a silicon fine particle, an aggregate of the silicon fine particles, or a crystal grain of silicon having a hydrogen-generating ability. Hydrogen generated from the silicon fine particle in the drug can contribute to the prevention and/or treatment of the kidney disease.

公开(公告)号：US20250032534A1

公开(公告)日：2025-01-30

申请号：US18883477

申请日：2024-09-12

Applicant: OSAKA UNIVERSITY

Inventor： Ryoichi IMAMURA ,  Hikaru KOBAYASHI ,  Yuki KOBAYASHI ,  Shinichiro FUKUHARA ,  Yusuke INAGAKI ,  Norio NONOMURA

IPC: A61K33/00 ,  A61K9/14

Abstract: One drug (preparation) of the present invention is a drug for a reproductive disorder containing a silicon fine particle, an aggregate of silicon fine particles or a crystal grain of silicon having a hydrogen-generating ability. Hydrogen generated from the silicon fine particle in the drug can contribute to the prevention and/or treatment of reproductive disorder.

公开(公告)号：US20220088064A1

公开(公告)日：2022-03-24

申请号：US17425294

申请日：2019-11-29

Applicant: OSAKA UNIVERSITY

Inventor： Ryoichi IMAMURA ,  Hikaru KOBAYASHI ,  Yuki KOBAYASHI ,  Shinichiro FUKUHARA ,  Yusuke INAGAKI ,  Norio NONOMURA

IPC: A61K33/00 ,  A61K9/14

Abstract: One drug (preparation) of the present invention is a drug for a reproductive disorder containing a silicon fine particle, an aggregate of silicon fine particles or a crystal grain of silicon having a hydrogen-generating ability. Hydrogen generated from the silicon fine particle in the drug can contribute to the prevention and/or treatment of reproductive disorder.

公开(公告)号：US20240189345A1

公开(公告)日：2024-06-13

申请号：US18550844

申请日：2022-01-17

Applicant: Osaka University

Inventor： Hisako KAYAMA ,  Kiyoshi TAKEDA ,  Hikaru KOBAYASHI ,  Yuki KOBAYASHI

IPC: A61K33/00 ,  A61K9/14 ,  A61P31/04

CPC classification number: A61K33/00 ,  A61K9/14 ,  A61P31/04

Abstract: An intestinal bacteria reducing agent of the present invention is a reducing agent which contains silicon particles or silicon fine particles and reduces the number of bacteria in the intestine. The intestinal bacteria reducing agent can reduce the number of bacteria in the intestine by a new action that cannot be explained by the heretofore known hydrogen generating capability of silicon particles or silicon fine particles, that is, the capability of eliminating hydroxyl radicals.

公开(公告)号：US20210145865A1

公开(公告)日：2021-05-20

申请号：US17113886

申请日：2020-12-07

Applicant: OSAKA UNIVERSITY

Inventor： Shoichi SHIMADA ,  Yoshihisa KOYAMA ,  Makoto KONDO ,  Noriyoshi USUI ,  Kazuya OHATA ,  Hidenori INOHARA ,  Hikaru KOBAYASHI ,  Yuki KOBAYASHI

IPC: A61K33/00 ,  A61P3/10 ,  A61P9/10 ,  A61P25/28 ,  A61P25/16 ,  A61P25/24 ,  A61P1/16 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P27/16

Abstract: An object is to provide a pharmaceutical or the like that can prevent or treat an oxidative stress-induced disease. Provided is a preventive or therapeutic agent for an oxidative stress-induced disease, pharmaceutical composition, medical device, hygienic product, food, or beverage containing silicon small particles. When the silicon small particles are orally administered or placed on a skin or a mucous membrane, the oxidative stress-induced disease can be prevented or treated. The oxidative stress-induced disease is an inflammatory disease, depression, or the like, and an excellent preventive and therapeutic effect thereon is obtained.