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    EVALUATION METHOD, PROGRAM, AND EVALUATION SYSTEM
    2.
    发明公开
    EVALUATION METHOD, PROGRAM, AND EVALUATION SYSTEM 审中-公开

    公开(公告)号：US20240008761A1

    公开(公告)日：2024-01-11

    申请号：US18265040

    申请日：2021-11-25

    Applicant: OSAKA UNIVERSITY

    Inventor： Hidetaka KIOKA ,  Yusuke TAKAHASHI ,  Shinichiro FUKUHARA ,  Yasushi SAKATA ,  Norio NONOMURA ,  Seiji TAKASHIMA ,  Shigeyoshi SAITO

    IPC: A61B5/055 ,  G01R33/485 ,  A61B5/00

    CPC classification number: A61B5/055 ,  G01R33/485 ,  A61B5/4387

    Abstract: An evaluation method is performed by an arithmetic circuit and includes obtainment processing (S1), evaluation processing (S2), and presentation processing (S3). The obtainment processing (S1) obtains: image information on a sectional image representing an interested section of an organism including a target section of a testis of the organism generated by use of magnetic resonance of hydrogen atoms; and concentration information on a creatine concentration in the interested section measured by use of magnetic resonance based on chemical exchange saturation transfer. The evaluation processing (S2) generates an evaluation image representing a distribution of evaluation results of a testicular function in the target section based on the concentration information. The presentation processing (S3) presents the sectional image and the evaluation image.

    METHOD FOR DETECTING CANCER BONE METASTASIS AND DETECTION REAGENT
    3.
    发明申请
    METHOD FOR DETECTING CANCER BONE METASTASIS AND DETECTION REAGENT 有权

    公开(公告)号：US20230053846A1

    公开(公告)日：2023-02-23

    申请号：US17778593

    申请日：2020-11-13

    Applicant: OSAKA UNIVERSITY ,  TOSOH CORPORATION

    Inventor： Motohide UEMURA ,  Norio NONOMURA ,  Takeshi UJIKE ,  Shohei MYOBA ,  Norihisa OHTAKE

    IPC: G01N33/574 ,  C07K16/22

    Abstract: A problem to be addressed by the present invention is to provide: a method for detecting bone metastasis of cancer (excluding castration resistant prostate cancer) in a simple and highly accurate manner; and a reagent that can be used in the method. Bone metastasis of cancer (excluding castration resistant prostate cancer) is detected by measuring an intact growth and differentiation factor 15 (GDF15) propeptide level, a GDF15 propeptide fragment level, and the total of an intact GDF15 propeptide level and a GDF15 propeptide fragment level in a sample. The above described method for detecting bone metastasis of cancer includes a method for detecting bone metastasis of prostate cancer other than castration resistant prostate cancer, renal cancer, lung cancer, breast cancer, thyroid cancer, pancreatic cancer, bladder cancer, colon cancer, melanoma, myeloma, or lymphoma. Further, the reagent for detecting bone metastasis of cancer (excluding castration resistant prostate cancer) includes an antibody that specifically recognizes GDF15 propeptide.

    METHOD FOR DETECTING PROSTATE CANCER
    9.
    发明申请
    METHOD FOR DETECTING PROSTATE CANCER 审中-公开

    公开(公告)号：US20200264182A1

    公开(公告)日：2020-08-20

    申请号：US16644545

    申请日：2018-09-21

    Applicant: J-OIL MILLS, INC. ,  OSAKA UNIVERSITY

    Inventor： Kazutoshi FUJITA ,  Norio NONOMURA ,  Eiji MIYOSHI ,  Yuka KOBAYASHI

    IPC: G01N33/574 ,  G01N33/68

    Abstract: [Problem] To provide a method for detecting prostate cancer, the method having a higher degree of certainty than the PSA blood test and providing measurement values that correlate with risk classification.[Solution] This method for detecting prostate cancer is characterized in that: the method includes reacting fucose α1→6 specific lectin and fucosylated PSA contained in a sample constituted of serum collected from a subject, and detecting the reacted lectin; and the pH in at least one step of the group consisting of the reaction step for reacting the fucosylated PSA and the lectin and processing steps thereafter is adjusted to above 8.5 and less than 11.0.

    METHOD, BIOMARKER AND DIAGNOSTIC AGENT FOR DETECTION OF HIGH-RISK PROSTATE CANCER
    10.
    发明申请
    METHOD, BIOMARKER AND DIAGNOSTIC AGENT FOR DETECTION OF HIGH-RISK PROSTATE CANCER 审中-公开

    公开(公告)号：US20190049451A1

    公开(公告)日：2019-02-14

    申请号：US16073217

    申请日：2017-02-03

    Applicant: J-OIL MILLS, INC. ,  OSAKA UNIVERSITY

    Inventor： Yuka KOBAYASHI ,  Kazutoshi FUJITA ,  Norio NONOMURA ,  Eiji MIYOSHI

    IPC: G01N33/574

    Abstract: [Problem] To provide a method for detecting high-risk prostate cancer, for the purpose of providing useful information, such as necessity of biopsy, to a test-positive patient in a PSA test.[Solution] The method for detecting high-risk prostate cancer according to the present invention comprises reacting a PSA contained in a sample composed of urine collected from a human body which is suspected to be suffering from prostate cancer with (1) a fucose α1→6 affinitive lectin which has a characteristic property that the lectin has affinity expressed by a binding constant of 1.0×104 M−1 or more (at 25° C.) for an α1→6 fucose sugar chain No. 405. The fucose α1→6 affinitive lectin is preferably (2) a fucose α1→6 specific lectin which has a characteristic property that the lectin has a binding constant of 1.0×104 M−1 or less (at 25° C.) for a sugar chain No. 003 that does not contain α1→6 fucose and a glycolipid-type sugar chain No. 909 that does not contain α1→6 fucose.

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