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1.发明授权Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections 失效环己烷碳环酯衍生物和环糊精复合物及治疗幽门螺杆菌感染的组合物公开(公告)号：US06444703B1
公开(公告)日：2002-09-03
申请号：US09091588
申请日：1998-08-12
申请人： Osamu Kamoda , Toshiharu Yanagi , Eiji Tamaki , Seiji Sato , Jun-ichi Mizoguchi
发明人： Osamu Kamoda , Toshiharu Yanagi , Eiji Tamaki , Seiji Sato , Jun-ichi Mizoguchi
IPC分类号： A61K3124
CPC分类号： B82Y5/00 , A61K31/24 , A61K47/6951
摘要： The present invention relates to a pharmaceutical composition which is appropriate for eradication or extermination of Helicobacter pylori wherein [4-[4-(4-methylbenzyloxycarbonyl)phenyl[phenyl trans-4-guanidinomethylcyclohexanecarboxylate or an acid addition salt thereof are compounded and it also relates to a complex consisting them.
摘要翻译： 本发明涉及一种适用于根除或消灭幽门螺杆菌的药物组合物，其中[4- [4-（4-甲基苄氧基羰基）苯基] [反式-4-胍基甲基环己烷甲酸苯酯或其酸加成盐被复合并且也涉及 到一个复杂的组成他们。
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公开(公告)号：US07485665B2
公开(公告)日：2009-02-03
申请号：US10526780
申请日：2002-09-12
IPC分类号： A61K31/40 , C07D207/04
CPC分类号： A61K31/40 , C07D207/14 , G01R33/3415 , G01R33/3806 , G01R33/5611
摘要： The present invention relates to an ameliorant for improving the movement of the digestive tract comprising, as an active ingredient, 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-2-hydroxymethyl-4-pyrrolidinyl]benzamide or an acid addition salt thereof which is a metabolite of 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide or an acid addition salt thereof, having high biding affinity for a serotonin receptor 4 (5HT4) and causing no arteritis and thrombus formation; a medicinal composition for improving the movement of the digestive tract comprising the said ameliorant and a pharmaceutically acceptable carrier; and a treating method for promoting the movement of the digestive tract, which comprises using the said medicinal composition for improving the movement of the digestive tract.
摘要翻译： 本发明涉及一种用于改善消化道运动的改善剂，其包含作为活性成分的4-氨基-5-氯-2-甲氧基-N - [（2S，4S）-2-羟甲基-4-吡咯烷基 ]苯甲酰胺或其酸加成盐，其为4-氨基-5-氯-2-甲氧基-N - [（2S，4S）-1-乙基-2-羟甲基-4-吡咯烷基]苯甲酰胺或酸的代谢物 其加成盐对5-羟色胺受体4（5HT4）具有高亲和力，不引起动脉炎和血栓形成; 用于改善消化道运动的药物组合物，其包含所述改善剂和药学上可接受的载体; 以及用于促进消化道运动的治疗方法，其包括使用所述药物组合物来改善消化道的移动。
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公开(公告)号：US06960681B2
公开(公告)日：2005-11-01
申请号：US10623135
申请日：2003-07-18
IPC分类号： A61K31/215 , A61K31/24 , C07C69/94 , C07C279/14 , C07C69/76
CPC分类号： C07C279/14 , A61K31/215 , A61K31/24 , C07C69/94 , C07C2601/14
摘要： The invention relates to novel and valuable intermediate compounds of the general formula (VIII) which can be used for the preparation of novel compounds comprising an antibacterial action, especially with a strong antibacterial action against helicobacter pylori, and pharmaceutically acceptable salts thereof. In the general formula (VIII) X is hydrogen or halogen, Y is hydrogen or a substituted or unsubstituted aralkyloxycarbonyl group having 8-19 carbon atoms, Z is hydrogen, a substituted aralkyloxycarbonyl group having 8-19 carbon atoms or a substituted alkoxycarbonyyl group having 2-19 carbon atoms, except that X, Y and Z are all hydrogen.
摘要翻译： 本发明涉及通式（Ⅷ）的新颖有价值的中间体化合物，其可用于制备包含抗菌作用的新化合物，特别是具有对幽门螺杆菌的强抗菌作用及其药学上可接受的盐。 在通式（Ⅷ）中，X为氢或卤素，Y为氢或具有8-19个碳原子的取代或未取代的芳烷氧基羰基，Z为氢，具有8-19个碳原子的取代芳烷氧基羰基或取代的烷氧基羰基， 2-19个碳原子，除了X，Y和Z都是氢。
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公开(公告)号：US20090118353A1
公开(公告)日：2009-05-07
申请号：US12318444
申请日：2008-12-30
IPC分类号： A61K31/40 , C07D207/14 , A61P1/14
CPC分类号： A61K31/40 , C07D207/14 , G01R33/3415 , G01R33/3806 , G01R33/5611
摘要： The present invention relates to an ameliorant for improving the movement of the digestive tract comprising, as an active ingredient, 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-2-hydroxymethyl-4-pyrrolidinyl]benzamide or an acid addition salt thereof which is a metabolite of 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide or an acid addition salt thereof, having high biding affinity for a serotonin receptor 4 (5HT4) and causing no arteritis and thrombus formation; a medicinal composition for improving the movement of the digestive tract comprising the said ameliorant and a pharmaceutically acceptable carrier; and a treating method for promoting the movement of the digestive tract, which comprises using the said medicinal composition for improving the movement of the digestive tract.
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公开(公告)号：US06284791B1
公开(公告)日：2001-09-04
申请号：US08793728
申请日：1997-02-28
IPC分类号： A61K31215
CPC分类号： C07C279/14 , A61K31/215 , A61K31/24 , C07C69/94 , C07C2601/14
摘要： A compound represented by general formula (I-2) or a pharmaceutically acceptable acid-addition salt thereof, useful as an anti-microbial against Helicobacter pylori and as a medicinal composition for treating Helicobacter pylori infection, wherein Ar represents phenyl, biphenyl or naphthyl each having a at least one substituent selected from the group consisting of halogen, cyano, nitro, carboxy, C1-C18 alkyl, C1-C18 alkoxy, C3-C18 cycloalkyl, C7-C18 aralkyl, C8-C18 arylalkenyl, C7-C18 aralkyloxy, optionally substituted phenoxy, optionally substituted C2-C19 alkoxycarbonyl, and optionally substituted C8-C19 aralkyloxycarbonyl, provided the case where Ar represents phenyl substituted by halogen, cyano, nitro, carboxy, C1-C18 alkyl, optionally substituted C2-C19 alkoxycarbonyl or C8-C19 aralkyloxycarbonyl is expected.
摘要翻译： 由通式（I-2）表示的化合物或其药学上可接受的酸加成盐可用作幽门螺杆菌的抗微生物剂和用作治疗幽门螺杆菌感染的药用组合物，其中Ar表示苯基，联苯基或萘基 具有至少一个选自卤素，氰基，硝基，羧基，C 1 -C 18烷基，C 1 -C 18烷氧基，C 3 -C 18环烷基，C 7 -C 18芳烷基，C 8 -C 18芳基烯基，C 7 -C 18芳烷氧基， 氰基，硝基，羧基，C 1 -C 18烷基，任意取代的C 2 -C 19烷氧基羰基或C 8 -C 19烷氧基羰基取代的苯基，任意取代的苯氧基，任意取代的C 2 -C 19烷氧羰基和任选取代的C 8 -C 19芳烷氧基羰基， C19芳烷氧基羰基是预期的。
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公开(公告)号：US20050239861A1
公开(公告)日：2005-10-27
申请号：US10526780
申请日：2002-09-12
IPC分类号： A61P1/14 , C07D207/14 , A61K31/40
CPC分类号： A61K31/40 , C07D207/14 , G01R33/3415 , G01R33/3806 , G01R33/5611
摘要： The present invention relates to an ameliorant for improving the movement of the digestive tract comprising, as an active ingredient, 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-2-hydroxymethyl-4-pirrolidinyl]benzamide or an acid addition salt thereof which is a metabolite of 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide or an acid addition salt thereof, having high biding affinity for a serotonin receptor 4 (5HT4) and causing no arteritis and thrombus formation; a medicinal composition for improving the movement of the digestive tract comprising the said ameliorant and a pharmaceutically acceptable carrier; and a treating method for promoting the movement of the digestive tract, which comprises using the said medicinal composition for improving the movement of the digestive tract.
摘要翻译： 本发明涉及用于改善消化道运动的改善剂，其包含作为活性成分的4-氨基-5-氯-2-甲氧基-N - [（2S，4S）-2-羟甲基-4-吡咯烷基 ]苯甲酰胺或其酸加成盐，其为4-氨基-5-氯-2-甲氧基-N - [（2S，4S）-1-乙基-2-羟甲基-4-吡咯烷基]苯甲酰胺或酸的代谢物 其加成盐对5-羟色胺受体4（5HT 4+）具有高亲和力，并且不引起动脉炎和血栓形成; 用于改善消化道运动的药物组合物，其包含所述改善剂和药学上可接受的载体; 以及用于促进消化道运动的治疗方法，其包括使用所述药物组合物来改善消化道的移动。
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公开(公告)号：US20050075402A1
公开(公告)日：2005-04-07
申请号：US10623135
申请日：2003-07-18
IPC分类号： A61K31/215 , A61K31/24 , C07C69/94 , C07C279/14 , C07C69/88 , A61K31/192
CPC分类号： C07C279/14 , A61K31/215 , A61K31/24 , C07C69/94 , C07C2601/14
摘要： The invention relates to novel and valuable intermediate compounds of the general formula (VIII) which can be used for the preparation of novel compounds comprising an antibacterial action, especially with a strong antibacterial action against helicobacter pylori, and pharmaceutically acceptable salts thereof. In the general formula (VIII) X is hydrogen or halogen, Y is hydrogen or a substituted or unsubstituted aralkyloxycarbonyl group having 8-19 carbon atoms, Z is hydrogen, a substituted aralkyloxycarbonyl group having 8-19 carbon atoms or a substituted alkoxycarbonyyl group having 2-19 carbon atoms, except that X, Y and Z are all hydrogen.
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公开(公告)号：US06831190B1
公开(公告)日：2004-12-14
申请号：US09721182
申请日：2000-11-22
IPC分类号： C07C6976
CPC分类号： C07C279/14 , A61K31/215 , A61K31/24 , C07C69/94 , C07C2601/14
摘要： The invention relates to novel and valuable intermediate compounds of the general formula (VIII) which can be used for the preparation of novel compounds comprising an antibacterial action, especially with a strong antibacterial action against helicobacter pylori, and pharmaceutically acceptable salts thereof. In the general formula (VIII) X is hydrogen or halogen, Y is hydrogen or a substituted or unsubstituted aralkyloxycarbonyl group having 8-19 carbon atoms, Z is hydrogen, a substituted aralkyloxycarbonyl group having 8-19 carbon atoms or a substituted alkoxycarbonyyl group having 2-19 carbon atoms, except that X, Y and Z are all hydrogen.
摘要翻译： 本发明涉及通式（Ⅷ）的新颖有价值的中间体化合物，其可用于制备包含抗菌作用的新化合物，特别是具有对幽门螺杆菌的强抗菌作用及其药学上可接受的盐。 在通式（Ⅷ）中，X为氢或卤素，Y为氢或具有8-19个碳原子的取代或未取代的芳烷氧基羰基，Z为氢，具有8-19个碳原子的取代芳烷氧基羰基或取代的烷氧基羰基， 2-19个碳原子，除了X，Y和Z都是氢。
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