公开(公告)号：US20140012010A1

公开(公告)日：2014-01-09

申请号：US13982707

申请日：2012-01-31

申请人： Osamu Onomura ,  Yutaro Tsuda ,  Masami Kuriyama ,  Toshiharu Yanagi ,  Kazuya Kodama

发明人： Osamu Onomura ,  Yutaro Tsuda ,  Masami Kuriyama ,  Toshiharu Yanagi ,  Kazuya Kodama

IPC分类号： C07D263/14 ,  C07D413/04

CPC分类号： C07D263/14 ,  C07B53/00 ,  C07D413/04 ,  C07D417/04

摘要： Provided is a process for producing an optically active compound represented by Formula (3): (wherein R1 is an alkyl group, an alkynyl group, an alkenyl group, an aliphatic heterocyclic group, a cycloalkyl group, an aryl group, an aralkyl group, or an aromatic heterocyclic group, and any hydrogen atom of R1 may be replaced with a substituent; R2 is a hydrogen atom or a group which is not reactive in the reaction below; and * represents a chiral center) or a salt thereof by subjecting a compound represented by Formula (1): (wherein R1 and R2 have the same meanings as defined in Formula (3)) to a ring closure reaction in the presence of a chiral ligand having 1 or more coordination sites, a Lewis acid represented by Formula (2): MmZn  (2) (wherein M is a metal ion, Z is a counter anion of M, and m and n are integers of 1 to 4), and a sulfonyl halide having an optionally substituted alkyl or phenyl group

摘要翻译： 提供一种制备由式（3）表示的光学活性化合物的方法：（其中R1是烷基，炔基，烯基，脂族杂环基，环烷基，芳基，芳烷基， 或芳族杂环基，R 1的任何氢原子可以被取代基取代; R2是氢原子或下述反应中不具有反应性的基团;和*表示手性中心）或其盐，通过使 由式（1）表示的化合物：其中R1和R2与式（3）中定义相同）在具有1个或多个配位点的手性配位体存在下进行闭环反应，式 （2）：MmZn（2）（其中M是金属离子，Z是M的抗衡阴离子，m和n是1〜4的整数）和具有任选取代的烷基或苯基的磺酰卤

公开(公告)号：US08969585B2

公开(公告)日：2015-03-03

申请号：US13982707

申请日：2012-01-31

申请人： Osamu Onomura ,  Yutaro Tsuda ,  Masami Kuriyama ,  Toshiharu Yanagi ,  Kazuya Kodama

发明人： Osamu Onomura ,  Yutaro Tsuda ,  Masami Kuriyama ,  Toshiharu Yanagi ,  Kazuya Kodama

IPC分类号： C07D263/14 ,  C07D413/04 ,  C07B53/00 ,  C07D417/04

CPC分类号： C07D263/14 ,  C07B53/00 ,  C07D413/04 ,  C07D417/04

摘要： Provided is a process for producing an optically active compound represented by Formula (3): (wherein R1 is an alkyl group, an alkynyl group, an alkenyl group, an aliphatic heterocyclic group, a cycloalkyl group, an aryl group, an aralkyl group, or an aromatic heterocyclic group, and any hydrogen atom of R1 may be replaced with a substituent; R2 is a hydrogen atom or a group which is not reactive in the reaction below; and * represents a chiral center) or a salt thereof by subjecting a compound represented by Formula (1): (wherein R1 and R2 have the same meanings as defined in Formula (3)) to a ring closure reaction in the presence of a chiral ligand having 1 or more coordination sites, a Lewis acid represented by Formula (2): MmZn  (2) (wherein M is a metal ion, Z is a counter anion of M, and m and n are integers of 1 to 4), and a sulfonyl halide having an optionally substituted alkyl or phenyl group.

摘要翻译： 提供一种制备由式（3）表示的光学活性化合物的方法：（其中R1是烷基，炔基，烯基，脂族杂环基，环烷基，芳基，芳烷基， 或芳族杂环基，R 1的任何氢原子可以被取代基取代; R2是氢原子或下述反应中不具有反应性的基团;和*表示手性中心）或其盐，通过使 由式（1）表示的化合物：其中R1和R2与式（3）中定义相同）在具有1个或多个配位点的手性配位体存在下进行闭环反应，式 （2）：MmZn（2）（其中M是金属离子，Z是M的抗衡阴离子，m和n是1〜4的整数）和具有任选取代的烷基或苯基的磺酰卤。