公开(公告)号：US6086896A

公开(公告)日：2000-07-11

申请号：US323477

申请日：1994-10-14

申请人： P. Frederick Sparling ,  Stuart Thompson

发明人： P. Frederick Sparling ,  Stuart Thompson

IPC分类号： A61K39/00 ,  A61P31/04 ,  C07K14/22 ,  C07K16/12 ,  A61K39/095 ,  A61K39/02 ,  G01N33/53

CPC分类号： C07K16/1217 ,  C07K14/22 ,  A61K39/00

摘要： An isolated, antigenic polypeptide comprises a segment having at least fifty amino acid residues. The amino acid sequence of the segment is present in N. meningitidis, and is different from, but substantially homologous with, the amino acid sequence of a segment of a member of the hemolysin family of toxins.

摘要翻译： 分离的抗原多肽包含具有至少50个氨基酸残基的区段。 该片段的氨基酸序列存在于脑膜炎奈瑟氏球菌中，并且与毒素溶血素家族成员的片段的氨基酸序列不同但基本上同源。

公开(公告)号：US06887482B2

公开(公告)日：2005-05-03

申请号：US10193950

申请日：2002-07-10

申请人： P. Frederick Sparling ,  Stuart Thompson

发明人： P. Frederick Sparling ,  Stuart Thompson

IPC分类号： A61K39/00 ,  C07K14/22 ,  C07K16/08 ,  C07K16/12 ,  A61K39/095

CPC分类号： C07K16/08 ,  A61K39/00 ,  C07K14/22 ,  C07K16/1217

摘要： An isolated, antigenic polypeptide comprises a segment having at least fifty amino acid residues. The amino acid sequence of the segment is present in N. meningitidis, and is different from, but substantially homologous with, the amino acid sequence of a segment of a member of the hemolysin family of toxins.

摘要翻译： 分离的抗原多肽包含具有至少50个氨基酸残基的区段。 该片段的氨基酸序列存在于脑膜炎奈瑟氏球菌中，并且与毒素溶血素家族成员的片段的氨基酸序列不同但基本上同源。

公开(公告)号：US08377636B2

公开(公告)日：2013-02-19

申请号：US12082762

申请日：2008-04-14

申请人： John D. Haley ,  Stuart Thompson

发明人： John D. Haley ,  Stuart Thompson

IPC分类号： G01N33/53 ,  G01N33/574

CPC分类号： G01N33/6893 ,  G01N33/5011 ,  G01N2333/4712 ,  G01N2333/4742 ,  G01N2333/91215

摘要： The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with inhibitors of EGFR kinase, PDGFR kinase, or FGFR kinase. Based on the surprising discovery that tumors cells after having undergone an EMT, while being mesenchymal-like, still express characteristics of both epithelial and mesenchymal cells, and that such cells have altered sensitivity to inhibition by receptor protein-tyrosine kinase inhibitors, in that they have become relatively insensitive to EGFR kinase inhibitors, but have frequently acquired sensitivity to inhibitors of other receptor protein-tyrosine kinases such as PDGFR or FGFR, methods have been devised for determining levels of specific epithelial and mesenchymal biomarkers that identify such “hybrid” tumor cells (e.g. determination of co-expression of vimentin and epithelial keratins), and thus predict the tumor's likely sensitivity to inhibitors of EGFR kinase, PDGFR kinase, or FGFR kinase. Improved methods for treating cancer patients with EGFR, PDGFR or FGFR kinase inhibitors that incorporate such methodology are also provided.

摘要翻译： 本发明提供用于预测具有EGFR激酶，PDGFR激酶或FGFR激酶抑制剂的癌症患者治疗有效性的诊断和预后方法。 基于令人惊讶的发现，肿瘤细胞在经历EMT之后，同时是间充质的，仍然表现出上皮细胞和间充质细胞的特征，并且这种细胞对受体蛋白 - 酪氨酸激酶抑制剂的抑制具有改变的敏感性，因为它们 已经对EGFR激酶抑制剂变得相对不敏感，但是经常对其他受体蛋白酪氨酸激酶（例如PDGFR或FGFR）的抑制剂获得敏感性，已经设计出用于确定鉴定这种杂合肿瘤细胞的特异性上皮和间充质生物标志物的水平的方法（例如 测定波形蛋白和上皮角蛋白的共表达），从而预测肿瘤对EGFR激酶，PDGFR激酶或FGFR激酶抑制剂的敏感性。 还提供了用于治疗结合这种方法的EGFR，PDGFR或FGFR激酶抑制剂的癌症患者的改进方法。

公开(公告)号：US20050106159A1

公开(公告)日：2005-05-19

申请号：US10916932

申请日：2004-08-12

申请人： Stuart Thompson

发明人： Stuart Thompson

IPC分类号： C07K16/12 ,  A61K39/00 ,  A61K48/00

CPC分类号： C07K16/121 ,  A61K2039/523

摘要： The field of this invention is the development of therapeutic agents having immunogenic efficacy against Campylobacter. The present invention is directed to a method of producing monoclonal antibodies that are highly specific for epitopes of Campylobacter jejuni outer membrane proteins; to specific monoclonal antibodies made by using the epitopes; and to uses thereof. The invention is drawn further to immunogens comprising certain outer membrane proteins or portions thereof from C. jejuni.

摘要翻译： 本发明的领域是对弯曲杆菌具有免疫原性功效的治疗剂的开发。 本发明涉及一种制备对空肠弯曲杆菌外膜蛋白的表位高度特异性的单克隆抗体的方法; 通过使用表位制备的特异性单克隆抗体; 并使用它们。 本发明进一步涉及包含某些外膜蛋白或其空肠弯曲杆菌的部分的免疫原。

公开(公告)号：US07952608B2

公开(公告)日：2011-05-31

申请号：US10533974

申请日：2003-10-30

申请人： Stuart Thompson

发明人： Stuart Thompson

IPC分类号： H04N7/18

CPC分类号： G08B13/19695 ,  G08B13/19602 ,  G08B13/1963 ,  G08B13/19632 ,  G08B13/19643 ,  G08B13/19656

摘要： A surveillance device has a support secured to a structure, a first image collection device secured to the support, a second image collection device and a servo motor, the second image collection device being moveable with respect to the support by the servo motor, the second image collection device having an optical axis whereby the servo motor is constructed and arranged to regulate the direction of the optical axis of the second image collection device. Inherent intelligence in the device or in a remote computer is used to direct the servo motor in accordance with algorithms recognizing and analyzing motion in the area being monitored by first image collection device.

摘要翻译： 监视装置具有固定到结构的支撑件，固定到支撑件的第一图像收集装置，第二图像收集装置和伺服电动机，第二图像收集装置可通过伺服电动机相对于支撑件移动，第二图像收集装置 具有光轴的图像采集装置，由此伺服电机被构造和布置成调节第二图像采集装置的光轴的方向。 装置或远程计算机中的固有智能被用于根据识别和分析由第一图像采集装置监视的区域中的运动的算法来引导伺服电动机。

公开(公告)号：US20090040302A1

公开(公告)日：2009-02-12

申请号：US11918881

申请日：2006-04-19

申请人： Stuart Thompson

发明人： Stuart Thompson

IPC分类号： H04N7/18

CPC分类号： G08B13/19673 ,  G08B13/19615 ,  G08B13/19641

摘要： An automated intelligent surveillance system comprises one or more fixed reference cameras to spatially map and observe a panoramic field of view, together with a movable narrow-field high resolution camera which is controlled in pan tilt & zoom, and a computing device. The computing device is capable of analysing the reference images received from anywhere within the panoramic field of view, and identifying the presence of specific types of object or specific behaviours of objects. The computing device uses the outcome of this analysis to direct the movable camera to the appropriate area of the spatial map to cause it to zoom in to gather close-up images of one or more of the selected objects or events of interest. These images are recorded synchronously with the related wide angle reference images, in a high speed random access store within the computing device. The parameters defining an object or event as being of interest may be pre-set, user selected, or adaptively learned by the computing device.

摘要翻译： 一种自动化智能监控系统，包括一个或多个固定参考摄像机，用于空间地映射和观察全景视场，以及以泛俯仰和变焦控制的可移动窄场高分辨率摄像机以及计算设备。 计算设备能够分析从全景视野内的任何地方接收到的参考图像，并且识别特定类型的对象或对象的特定行为的存在。 计算设备使用该分析的结果将可移动摄像机引导到空间地图的适当区域，以使其放大以收集一个或多个所选对象或感兴趣的事件的特写图像。 在计算设备内的高速随机存取存储器中，与相关的广角参考图像同步地记录这些图像。 将对象或事件定义为感兴趣的参数可以被计算设备预先设置，用户选择或自适应地学习。

公开(公告)号：US20070109407A1

公开(公告)日：2007-05-17

申请号：US10533974

申请日：2003-10-30

申请人： Stuart Thompson

发明人： Stuart Thompson

IPC分类号： H04N7/18

CPC分类号： G08B13/19695 ,  G08B13/19602 ,  G08B13/1963 ,  G08B13/19632 ,  G08B13/19643 ,  G08B13/19656

摘要： A surveillance device has a support secured to a structure, a first image collection device secured to the support, a second image collection device and a servo motor, the second image collection device being moveable with respect to the support by the servo motor, the second image collection device having an optical axis whereby the servo motor is constructed and arranged to regulate the direction of the optical axis of the second image collection device. Inherent intelligence in the device or in a remote computer is used to direct the servo motor in accordance with algorithms recognising and analysing motion in the area being monitored by first image collection device.

摘要翻译： 监视装置具有固定到结构的支撑件，固定到支撑件的第一图像收集装置，第二图像收集装置和伺服电动机，第二图像收集装置可通过伺服电动机相对于支撑件移动，第二图像收集装置 具有光轴的图像采集装置，由此伺服电机被构造和布置成调节第二图像采集装置的光轴的方向。 装置或远程计算机中的固有智能被用于根据识别和分析由第一图像采集装置监视的区域中的运动的算法来引导伺服电动机。