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1.发明授权Substituted phenylamine carboxamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same 失效取代的苯胺甲酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法公开(公告)号：US08501757B2
公开(公告)日：2013-08-06
申请号：US12885420
申请日：2010-09-17
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
IPC分类号： A61K31/505 , A61K31/44 , C07D239/02 , C07D403/12 , C07D401/12 , C07D213/62 , A61K31/4965
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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2.发明授权6-alkyl-N-(pyridin-2-yl)-4-aryloxypicolinamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same 有权6-烷基-N-（吡啶-2-基）-4-芳氧基吡啶啉酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法公开(公告)号：US09085562B2
公开(公告)日：2015-07-21
申请号：US14002309
申请日：2012-03-05
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
IPC分类号： C07D401/14 , A61K31/513 , C07D213/81 , C07D401/12
CPC分类号： C07D401/14 , A61K31/513 , C07D213/81 , C07D401/12
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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3.发明申请6-ALKYL-N-(PYRIDIN-2-YL)-4-ARYLOXYPICOLINAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 有权6-ALKYL-N-（吡啶-2-基）-4-氰基酰胺酰胺类似物作为MGLUR5阴离子型调节剂及其制备和使用方法公开(公告)号：US20140206707A1
公开(公告)日：2014-07-24
申请号：US14002309
申请日：2012-03-05
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61K31/513 , C07D213/81 , C07D401/12
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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4.发明申请SUBSTITUTED PHENYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 失效取代的苯胺羧酰胺类似物作为MGLUR5阴离子型调节剂及其制备和使用方法公开(公告)号：US20110166158A1
公开(公告)日：2011-07-07
申请号：US12885420
申请日：2010-09-17
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
IPC分类号： A61K31/497 , C07D213/65 , C07D239/34 , C07D401/12 , C07D403/14 , A61K31/444 , A61K31/506 , C07D401/14 , A61P25/00 , A61P25/22 , A61P25/30 , A61P25/16 , A61P1/04
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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5.发明申请SUBSTITUTED HETEROARYLAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 失效替代酰胺酰胺模拟物作为MGLUR5负离子调节剂及其制备和使用方法公开(公告)号：US20110172248A1
公开(公告)日：2011-07-14
申请号：US12885289
申请日：2010-09-17
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
IPC分类号： A61K31/497 , C07D213/65 , C07D239/34 , C07D401/12 , C07D403/14 , C07D401/14 , A61K31/444 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/30 , A61P25/16 , A61P1/04
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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6.发明授权Substituted benzamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same 有权取代的苯甲酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法公开(公告)号：US08796295B2
公开(公告)日：2014-08-05
申请号：US12885378
申请日：2010-09-17
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
IPC分类号： A61K31/505 , A61K31/44 , C07D239/02 , C07D417/12
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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7.发明申请SUBSTITUTED HETEROARYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 失效取代的异喹啉羧酰胺类似物作为MGLUR5阴离子型调节剂及其制备和使用方法公开(公告)号：US20110172247A1
公开(公告)日：2011-07-14
申请号：US12885245
申请日：2010-09-17
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
IPC分类号： A61K31/497 , C07D213/65 , C07D239/34 , C07D401/12 , C07D401/14 , C07D403/14 , A61K31/444 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/30 , A61P25/16 , A61P1/04
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明
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8.发明授权Substituted heteroarylamine carboxamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same 失效取代的杂芳基胺甲酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法公开(公告)号：US08569308B2
公开(公告)日：2013-10-29
申请号：US12885245
申请日：2010-09-17
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
IPC分类号： A01N37/30 , A61K31/205
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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9.发明授权Substituted heteroarylamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same 失效取代的杂芳基酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法公开(公告)号：US08598345B2
公开(公告)日：2013-12-03
申请号：US12885289
申请日：2010-09-17
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
IPC分类号： C07D401/12 , C07D213/65 , A61P29/00 , A61P25/22
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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10.发明申请SUBSTITUTED BENZAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 有权取代的苯甲酰胺模拟物作为MGLUR5阴离子型调节剂及其制备和使用方法公开(公告)号：US20110152299A1
公开(公告)日：2011-06-23
申请号：US12885378
申请日：2010-09-17
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones
IPC分类号： A61K31/506 , C07D401/12 , A61K31/4439 , C07D403/12 , A61P25/22 , A61P25/16 , A61P29/00 , A61P1/04
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明
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