公开(公告)号：US20230405052A1

公开(公告)日：2023-12-21

申请号：US18251869

申请日：2021-11-05

申请人： Paean Biotechnology Inc.

发明人： Chun-Hyung Kim ,  Kyuboem Han ,  Shin-Hye Yu ,  Yu Jin Kim ,  Seo-Eun Lee ,  Jong Hyeok Park ,  Gayoung Cho

IPC分类号： A61K35/28 ,  A61P11/00

CPC分类号： A61K35/28 ,  A61P11/00

摘要： The present invention relates to a pharmaceutical composition for preventing or treating fibrosis and, more specifically, to a pharmaceutical composition for preventing or treating fibrosis, comprising mitochondria as an active ingredient. When the pharmaceutical composition of the present invention comprising exogenous mitochondria as an active ingredient is administered to a subject suffering from fibrosis such as pulmonary fibrosis, hepatic fibrosis and renal fibrosis, the fibrosis of tissues may be inhibited. In addition, the pharmaceutical composition of the present invention effectively inhibits the expression of fibronectin, CTGF2, α-SMA, collagen 1A and the like during treatment of TGF-β. Therefore, the pharmaceutical composition according to the present invention may be effectively used in the prevention or treatment of fibrosis.

公开(公告)号：US12128070B2

公开(公告)日：2024-10-29

申请号：US17483193

申请日：2021-09-23

申请人： PAEAN BIOTECHNOLOGY INC.

发明人： Kyuboem Han ,  Youngjun Lee

IPC分类号： A61K35/17 ,  A61K9/08 ,  A61K9/19 ,  A61K35/15 ,  A61P35/00 ,  A61P35/02 ,  C12N5/078 ,  C12N5/0783

CPC分类号： A61K35/17 ,  A61K9/08 ,  A61K9/19 ,  A61K35/15 ,  A61P35/00 ,  A61P35/02 ,  C12N5/0634 ,  C12N5/0646

摘要： An NK cells and PBMC, both having increased cytotoxicity are provided. Particularly, NK cells and PBMC which have exogenous mitochondria introduced thereinto potentiate the immune system of the human body to enhance a therapeutic effect on infectious diseases or cancer. Therefore, the NK cells and PBMC can be used in a composition for prevention or treatment of infectious diseases and cancer. Specially, autogenous NK cells and PBMC guarantee stability without the incurrence of an immune reaction, and thus would be expected to have high commercial activity.

公开(公告)号：US11278569B2

公开(公告)日：2022-03-22

申请号：US16349310

申请日：2017-11-14

申请人： PAEAN BIOTECHNOLOGY INC.

发明人： Kyuboem Han ,  Youngjun Lee

IPC分类号： A61K35/17 ,  A61P35/02 ,  A61P35/00 ,  C12N5/078 ,  C12N5/0783 ,  A61K35/15 ,  A61K9/19 ,  A61K9/08

摘要： An NK cells and PBMC, both having increased cytotoxicity are provided. Particularly, NK cells and PBMC which have exogenous mitochondria introduced thereinto potentiate the immune system of the human body to enhance a therapeutic effect on infectious diseases or cancer. Therefore, the NK cells and PBMC can be used in a composition for prevention or treatment of infectious diseases and cancer. Specially, autogenous NK cells and PBMC guarantee stability without the incurrence of an immune reaction, and thus would be expected to have high commercial activity.