公开(公告)号：US20130129753A1

公开(公告)日：2013-05-23

申请号：US13670612

申请日：2012-11-07

Applicant: PFIZER INC.

Inventor： Matthew David DOROSKI ,  Andreas MADERNA ,  Christopher John O'DONNELL ,  Chakrapani SUBRAMANYAM ,  Beth VETELINO ,  Russell George DUSHIN ,  Pavel STROP ,  Edmund Idris GRAZIANI

IPC: C07K7/02 ,  C07K5/02 ,  C07K16/00

CPC classification number: C07K7/06 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6863 ,  A61K47/6889 ,  C07K5/0205 ,  C07K5/0808 ,  C07K7/02 ,  C07K16/00 ,  C07K2319/30

Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.

公开(公告)号：US20150307551A1

公开(公告)日：2015-10-29

申请号：US14793942

申请日：2015-07-08

Applicant: PFIZER INC.

Inventor： Matthew David DOROSKI ,  Andreas MADERNA ,  Christopher John O'DONNELL ,  Chakrapani SUBRAMANYAM ,  Beth VETELINO ,  Russell George DUSHIN ,  Pavel STROP ,  Edmund Idris GRAZIANI

IPC: C07K7/06

CPC classification number: C07K7/06 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6863 ,  A61K47/6889 ,  C07K5/0205 ,  C07K5/0808 ,  C07K7/02 ,  C07K16/00 ,  C07K2319/30

Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.

Abstract translation: 本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。

公开(公告)号：US20140363452A1

公开(公告)日：2014-12-11

申请号：US14322262

申请日：2014-07-02

Applicant: PFIZER INC.

Inventor： Matthew David DOROSKI ,  Andreas MADERNA ,  Christopher John O'DONNELL ,  Chakrapani SUBRAMANYAM ,  Beth VETELINO ,  Russell George DUSHIN ,  Pavel STROP ,  Edmund Idris GRAZIANI

IPC: A61K47/48 ,  A61K38/06 ,  A61K38/08 ,  A61K38/07 ,  C07K7/02 ,  C07K5/083 ,  C07K5/02

CPC classification number: C07K7/06 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6863 ,  A61K47/6889 ,  C07K5/0205 ,  C07K5/0808 ,  C07K7/02 ,  C07K16/00 ,  C07K2319/30

Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.

Abstract translation: 本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。