公开(公告)号：US20230146072A1

公开(公告)日：2023-05-11

申请号：US17917886

申请日：2021-10-14

Applicant: PFIZER INC.

Inventor： Chew Shun CHANG ,  Divya MATHUR ,  Adam Reid ROOT

IPC: C07K16/40 ,  G01N33/574

CPC classification number: C07K16/40 ,  G01N33/574 ,  C07K2317/565 ,  C07K2317/24 ,  C07K2317/33

Abstract: The present invention is directed to antibodies that specifically bind to GUCY2c and methods of using such antibodies in the diagnosis and/or treatment of cancer.

公开(公告)号：US20230340151A1

公开(公告)日：2023-10-26

申请号：US17975508

申请日：2022-10-27

Applicant: PFIZER INC.

Inventor： Chew Shun CHANG ,  Gurkan GUNTAS ,  Madan KATRAGADDA ,  Divya MATHUR ,  Adam Reid ROOT ,  Lidia MOSYAK ,  Edward Roland LAVALLIE

IPC: C07K16/40 ,  A61P35/00

CPC classification number: C07K16/40 ,  A61P35/00 ,  A61K45/06

Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.