公开(公告)号：US20230146072A1

公开(公告)日：2023-05-11

申请号：US17917886

申请日：2021-10-14

Applicant: PFIZER INC.

Inventor： Chew Shun CHANG ,  Divya MATHUR ,  Adam Reid ROOT

IPC: C07K16/40 ,  G01N33/574

CPC classification number: C07K16/40 ,  G01N33/574 ,  C07K2317/565 ,  C07K2317/24 ,  C07K2317/33

Abstract: The present invention is directed to antibodies that specifically bind to GUCY2c and methods of using such antibodies in the diagnosis and/or treatment of cancer.

公开(公告)号：US20230340151A1

公开(公告)日：2023-10-26

申请号：US17975508

申请日：2022-10-27

Applicant: PFIZER INC.

Inventor： Chew Shun CHANG ,  Gurkan GUNTAS ,  Madan KATRAGADDA ,  Divya MATHUR ,  Adam Reid ROOT ,  Lidia MOSYAK ,  Edward Roland LAVALLIE

IPC: C07K16/40 ,  A61P35/00

CPC classification number: C07K16/40 ,  A61P35/00 ,  A61K45/06

Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.

公开(公告)号：US20160002357A1

公开(公告)日：2016-01-07

申请号：US14751704

申请日：2015-06-26

Applicant: Pfizer Inc.

Inventor： Chad Michael MAY ,  Adam Reid ROOT ,  William A. BRADY ,  Lioudmila Gennadievna TCHISTIAKOVA ,  Lidia MOSYAK ,  Laird BLOOM ,  Paul A. MOORE ,  Leslie S. JOHNSON

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/18

CPC classification number: C07K16/468 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/626 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/94

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.

Abstract translation: 双特异性二聚体双抗体分子及其在治疗癌症中的用途。 双特异性异二聚体双抗体分子包含两个多肽链，其连接形成识别P-钙粘蛋白肿瘤细胞相关抗原和CD3T细胞抗原的两个表位结合位点。