公开(公告)号：US20200283536A1

公开(公告)日：2020-09-10

申请号：US16758124

申请日：2018-10-16

Applicant: Pfizer Inc.

Inventor： Manoj Baburao CHARATI ,  Yoon-Chi HAN ,  Madan KATRAGADDA ,  Nicole Melissa PICHÉ-NICHOLAS ,  Lawrence Nathan TUMEY

IPC: C07K16/28 ,  A61K47/68 ,  C12N15/63 ,  A61P35/00

Abstract: The present invention provides antibodies that specifically bind to CD123. The invention further relates to immunoconjugates (e.g., antibody-drug conjugates, or ADCs) comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and ADCs for the treatment of a condition associated with cells expressing CD123 (e.g., cancer or autoimmune disease).

公开(公告)号：US20230357417A1

公开(公告)日：2023-11-09

申请号：US18180704

申请日：2023-03-08

Applicant: Pfizer Inc.

Inventor： Manoj Baburao CHARATI ,  Yoon-Chi HAN ,  Madan KATRAGADDA ,  Nicole Melissa PICHÉ-NICHOLAS ,  Lawrence Nathan TUMEY

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C12N15/63

CPC classification number: C07K16/2866 ,  A61K47/6851 ,  A61K47/6803 ,  A61P35/00 ,  C12N15/63 ,  A61K2039/505

Abstract: The present invention provides antibodies that specifically bind to CD123. The invention further relates to immunoconjugates (e.g., antibody-drug conjugates, or ADCs) comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and ADCs for the treatment of a condition associated with cells expressing CD123 (e.g., cancer or autoimmune disease).

公开(公告)号：US20230340151A1

公开(公告)日：2023-10-26

申请号：US17975508

申请日：2022-10-27

Applicant: PFIZER INC.

Inventor： Chew Shun CHANG ,  Gurkan GUNTAS ,  Madan KATRAGADDA ,  Divya MATHUR ,  Adam Reid ROOT ,  Lidia MOSYAK ,  Edward Roland LAVALLIE

IPC: C07K16/40 ,  A61P35/00

CPC classification number: C07K16/40 ,  A61P35/00 ,  A61K45/06

Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.