公开(公告)号：US20240182468A1

公开(公告)日：2024-06-06

申请号：US18484527

申请日：2023-10-11

Applicant: PFIZER INC.

Inventor： GARY ERIK ASPNES ,  CHRISTOPHER RYAN BUTLER ,  MATTHEW FRANK PAUL CALABRESE ,  KIMBERLY O'KEEFE CAMERON ,  JOHN MARION CURTO ,  MICHAEL ERIC GREEN ,  XINJUN HOU ,  SHENPING LIU ,  CHRISTOPHER LEE MCCLENDON ,  JOHN CHARLES MURRAY ,  ADVAITA PANCHAGNULA ,  COLIN RICHARD ROSE ,  KYLE THOMAS TARANTINO ,  MEIHUA MIKE TU ,  RAYOMAND JAL UNWALLA ,  JOSEPH SCOTT WARMUS ,  JUN XIAO ,  QINGYI YANG ,  LEI ZHANG

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D519/00

Abstract: Described herein are compounds of Formula I,






wherein the variables are defined herein, their use as activators from AMPK, pharmaceutical compositions containing such compounds and their use to treat, for example, heart failure or peripheral vascular disease.