公开(公告)号：US20240182468A1

公开(公告)日：2024-06-06

申请号：US18484527

申请日：2023-10-11

Applicant: PFIZER INC.

Inventor： GARY ERIK ASPNES ,  CHRISTOPHER RYAN BUTLER ,  MATTHEW FRANK PAUL CALABRESE ,  KIMBERLY O'KEEFE CAMERON ,  JOHN MARION CURTO ,  MICHAEL ERIC GREEN ,  XINJUN HOU ,  SHENPING LIU ,  CHRISTOPHER LEE MCCLENDON ,  JOHN CHARLES MURRAY ,  ADVAITA PANCHAGNULA ,  COLIN RICHARD ROSE ,  KYLE THOMAS TARANTINO ,  MEIHUA MIKE TU ,  RAYOMAND JAL UNWALLA ,  JOSEPH SCOTT WARMUS ,  JUN XIAO ,  QINGYI YANG ,  LEI ZHANG

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D519/00

Abstract: Described herein are compounds of Formula I,






wherein the variables are defined herein, their use as activators from AMPK, pharmaceutical compositions containing such compounds and their use to treat, for example, heart failure or peripheral vascular disease.

公开(公告)号：US20150322043A1

公开(公告)日：2015-11-12

申请号：US14705272

申请日：2015-05-06

Applicant: PFIZER INC

Inventor： SHARANJEET KAUR BAGAL ,  JINGRONG JEAN CUI ,  SAMANTHA ELIZABETH GREASLEY ,  ELIZABETH ANN LUNNEY ,  INDRAWAN JAMES MCALPINE ,  ASAKO NAGATA ,  SACHA NINKOVIC ,  KIYOYUKI OMOTO ,  SARAH ELIZABETH SKERRATT ,  ROBERT IAN STORER ,  JOSEPH SCOTT WARMUS

IPC: C07D401/14 ,  C07D413/14 ,  C07D401/12

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to compounds of Formula I and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.

Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐，其中取代基如本文所述，及其在药物中的用途，特别是作为TrkA拮抗剂。