-
1.发明申请公开(公告)号：US20240374699A1
公开(公告)日：2024-11-14
申请号：US18531055
申请日：2023-12-06
Applicant: Pfizer Inc.
Inventor： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
-
2.发明授权公开(公告)号：US11090375B2
公开(公告)日：2021-08-17
申请号：US16899738
申请日：2020-06-12
Applicant: Pfizer Inc.
Inventor： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
Abstract: The present invention relates to new immunogenic compositions comprising conjughated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
-
公开(公告)号：US10745438B2
公开(公告)日：2020-08-18
申请号：US16505757
申请日：2019-07-09
Applicant: Pfizer Inc.
Inventor： Mingming Han , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad
IPC: C07K1/107 , C07K14/34 , C07K14/22 , C07K14/315 , A61K39/095 , A61K39/09 , A61K47/64 , C07H3/06 , A61K39/00
Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
-
公开(公告)号：US20230346903A1
公开(公告)日：2023-11-02
申请号：US18060779
申请日：2022-12-01
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Amardeep Singh Bhupender Bhalla , Robert G.K. Donald , Jianxin Gu , Kathrin Ute Jansen , Rajesh Kumar Kainthan , Lakshmi Khandke , Jin-Hwan Kim , Paul Liberator , Avvari Krishna Prasad , Mark Edward Ruppen , Ingrid Lea Scully , Suddham Singh , Cindy Xudong Yang
CPC classification number: A61K39/092 , C07K16/1275 , C07K16/44 , A61K39/39 , A61K39/40 , A61K47/10 , A61K47/26 , A61K2039/505
Abstract: The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide-protein conjugates, wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
-
公开(公告)号：US20210371453A1
公开(公告)日：2021-12-02
申请号：US17400938
申请日：2021-08-12
Applicant: Pfizer Inc.
Inventor： Mingming Han , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad
IPC: C07K1/107 , C07K14/34 , C07K14/22 , C07K14/315 , A61K39/095 , A61K39/09 , A61K47/64 , C07H3/06
Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
-
Patent Agency Ranking
公开(公告)号：US20210145957A1
公开(公告)日：2021-05-20
申请号：US17161119
申请日：2021-01-28
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Amardeep Singh Bhupender Bhalla , Robert G.K. Donald , Jianxin Gu , Kathrin Ute Jansen , Rajesh Kumar Kainthan , Lakshmi Khandke , Jin-Hwan Kim , Paul Liberator , Avvari Krishna Prasad , Mark Edward Ruppen , Ingrid Lea Scully , Suddham Singh , Cindy Xudong Yang
Abstract: The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B. streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide-protein conjugates, wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
-
公开(公告)号：US10392420B2
公开(公告)日：2019-08-27
申请号：US14652723
申请日：2013-12-13
Applicant: Pfizer Inc.
Inventor： Mingming Han , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad
IPC: C07K1/107 , C07K14/34 , C07K14/22 , C07K14/315 , A61K39/095 , A61K39/09 , C07H3/06 , A61K47/64 , A61K39/00
Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
-
公开(公告)号：US20190000953A1
公开(公告)日：2019-01-03
申请号：US16133021
申请日：2018-09-17
Applicant: Pfizer Inc.
Inventor： Jianxin Gu , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad , Yu-Ying Yang
IPC: A61K39/09 , A61K39/39 , A61K39/385 , A61K39/00
Abstract: The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation. The invention also relates to immunogenic conjugates comprising Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides covalently linked to a carrier protein, processes for their preparation and immunogenic compositions and vaccines comprising them.
-
公开(公告)号：US10105431B2
公开(公告)日：2018-10-23
申请号：US15110634
申请日：2015-01-15
Applicant: Pfizer Inc.
Inventor： Jianxin Gu , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad , Yu-Ying Yang
Abstract: The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation. The invention also relates to immunogenic conjugates comprising Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides covalently linked to a carrier protein, processes for their preparation and immunogenic compositions and vaccines comprising them.
-
公开(公告)号：US11603384B2
公开(公告)日：2023-03-14
申请号：US17400938
申请日：2021-08-12
Applicant: Pfizer Inc.
Inventor： Mingming Han , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad
IPC: C07K1/107 , A61K39/095 , C07K14/34 , C07K14/22 , C07K14/315 , A61K39/09 , A61K47/64 , C07H3/06 , A61K39/00
Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
-
-
-
-
-
-
-
-
-
Search Results
34
records
(took 0.027 seconds)
