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公开(公告)号：US20200246448A1
公开(公告)日：2020-08-06
申请号：US16774309
申请日：2020-01-28
申请人： PFIZER INC.
发明人： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC分类号： A61K39/095 , A61K47/64 , A61K45/06 , A61K39/09
摘要： The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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2.发明申请公开(公告)号：US20180099039A1
公开(公告)日：2018-04-12
申请号：US15286696
申请日：2016-10-06
申请人： Pfizer Inc.
发明人： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
CPC分类号： A61K39/092 , A61K47/646 , A61K2039/55505 , A61K2039/6037 , A61K2039/70 , Y02A50/466
摘要： The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.
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3.发明授权公开(公告)号：US11090375B2
公开(公告)日：2021-08-17
申请号：US16899738
申请日：2020-06-12
申请人： Pfizer Inc.
发明人： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
摘要： The present invention relates to new immunogenic compositions comprising conjughated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
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公开(公告)号：US20170224804A1
公开(公告)日：2017-08-10
申请号：US15347034
申请日：2016-11-09
申请人： PFIZER INC.
发明人： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC分类号： A61K39/095 , A61K39/09
CPC分类号： A61K39/095 , A61K39/092 , A61K45/06 , A61K47/64 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , A61K2039/627
摘要： The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US20150216996A1
公开(公告)日：2015-08-06
申请号：US14420822
申请日：2013-08-12
申请人： PFIZER INC.
发明人： Jianxin Gu , Jin-hwan Kim , A. Krishna Prasad , Yu-ying Yang
CPC分类号： A61K39/095 , A61K39/092 , A61K45/06 , A61K47/64 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , A61K2039/627
摘要： The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
摘要翻译： 本发明提供了包含通过（2 - （（2-氧代乙基）硫基）乙基）氨基甲酸酯（eTEC）间隔物共价结合载体蛋白质的糖的eTEC连接的糖缀合物，包含这种糖缀合物的免疫原性组合物，以及制备和使用 这样的糖缀合物和免疫原性组合物。
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公开(公告)号：US11723965B2
公开(公告)日：2023-08-15
申请号：US17395108
申请日：2021-08-05
申请人： PFIZER INC.
发明人： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC分类号： A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06 , A61K39/00
CPC分类号： A61K39/095 , A61K39/092 , A61K45/06 , A61K47/64 , A61K47/646 , A61K47/6415 , A61K2039/6037 , A61K2039/6068 , A61K2039/627
摘要： The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US20220096619A1
公开(公告)日：2022-03-31
申请号：US17395108
申请日：2021-08-05
申请人： PFIZER INC.
发明人： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC分类号： A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06
摘要： The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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8.发明授权公开(公告)号：US11160855B2
公开(公告)日：2021-11-02
申请号：US15286696
申请日：2016-10-06
申请人： Pfizer Inc.
发明人： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
摘要： The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.
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公开(公告)号：US10583187B2
公开(公告)日：2020-03-10
申请号：US15946664
申请日：2018-04-05
申请人： PFIZER INC.
发明人： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC分类号： A61K39/395 , A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06 , A61K39/00
摘要： The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US20180221467A1
公开(公告)日：2018-08-09
申请号：US15946664
申请日：2018-04-05
申请人： PFIZER INC.
发明人： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC分类号： A61K39/095
摘要： The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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