公开(公告)号：US11993625B2

公开(公告)日：2024-05-28

申请号：US16477290

申请日：2018-01-10

Applicant: PFIZER INC.

Inventor： Omar Khaled Ahmad ,  Stephen Paul Brown ,  Kenneth John Dirico ,  Russell Dushin ,  Gary Frederick Filzen ,  Sujiet Puthenveetil ,  Pavel Strop ,  Chakrapani Subramanyam ,  Lawrence N. Tumey

IPC: C07H15/26 ,  A61K47/68 ,  A61P35/00 ,  A61K45/06

CPC classification number: C07H15/26 ,  A61K47/6807 ,  A61P35/00 ,  A61K45/06

Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.

公开(公告)号：US20240409573A1

公开(公告)日：2024-12-12

申请号：US18627949

申请日：2024-04-05

Applicant: PFIZER INC.

Inventor： Omar Khaled Ahmad ,  Stephen Paul Brown ,  Kenneth John Dirico ,  Russell Dushin ,  Gary Frederick Filzen ,  Sujiet Puthenveetil ,  Pavel Strop ,  Chakrapani Subramanyam ,  Lawrence N. Tumey

IPC: C07H15/26 ,  A61K45/06 ,  A61K47/68 ,  A61P35/00

Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.