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公开(公告)号：US09764040B2
公开(公告)日：2017-09-19
申请号：US15280563
申请日：2016-09-29
Applicant: PFIZER INC.
Inventor： Chakrapani Subramanyam , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K38/00 , A61K47/48 , C07D309/10 , C07D405/12 , C07D493/20 , A61K45/06 , C07D309/14 , C07D405/14 , C07D493/10 , A61K31/351 , A61K31/397 , A61K31/453 , A61K31/496 , A61K31/501 , A61K31/35 , A61K31/4025
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
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Patent Agency Ranking
公开(公告)号：US20160022626A1
公开(公告)日：2016-01-28
申请号：US14818455
申请日：2015-08-05
Applicant: PFIZER INC.
Inventor： Chakrapani SUBRAMANYAM , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K31/351 , A61K47/48 , A61K31/496 , A61K31/501 , A61K31/453 , A61K31/397
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
Abstract translation: 本发明涉及新颖的细胞毒素剪接抑制物类似物及其衍生物，其抗体药物偶联物及其用于治疗包括癌症在内的医学病症的方法。
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公开(公告)号：US11993625B2
公开(公告)日：2024-05-28
申请号：US16477290
申请日：2018-01-10
Applicant: PFIZER INC.
Inventor： Omar Khaled Ahmad , Stephen Paul Brown , Kenneth John Dirico , Russell Dushin , Gary Frederick Filzen , Sujiet Puthenveetil , Pavel Strop , Chakrapani Subramanyam , Lawrence N. Tumey
CPC classification number: C07H15/26 , A61K47/6807 , A61P35/00 , A61K45/06
Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.
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公开(公告)号：US09169264B2
公开(公告)日：2015-10-27
申请号：US14069057
申请日：2013-10-31
Applicant: PFIZER INC.
Inventor： Chakrapani Subramanyam , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K38/00 , C07K16/00 , C07D493/10 , C07D309/10 , C07D405/12 , C07D493/20 , A61K45/06 , A61K47/48 , C07D309/14 , C07D405/14
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
Abstract translation: 本发明涉及新颖的细胞毒素剪接抑制物类似物及其衍生物，其抗体药物偶联物及其用于治疗包括癌症在内的医学病症的方法。
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公开(公告)号：US20240409573A1
公开(公告)日：2024-12-12
申请号：US18627949
申请日：2024-04-05
Applicant: PFIZER INC.
Inventor： Omar Khaled Ahmad , Stephen Paul Brown , Kenneth John Dirico , Russell Dushin , Gary Frederick Filzen , Sujiet Puthenveetil , Pavel Strop , Chakrapani Subramanyam , Lawrence N. Tumey
Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.
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公开(公告)号：US09504669B2
公开(公告)日：2016-11-29
申请号：US14818455
申请日：2015-08-05
Applicant: PFIZER INC.
Inventor： Chakrapani Subramanyam , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K38/00 , A61K31/351 , C07D309/10 , C07D405/12 , C07D493/20 , A61K45/06 , A61K47/48 , C07D309/14 , C07D405/14 , C07D493/10 , A61K31/397 , A61K31/453 , A61K31/496 , A61K31/501
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
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