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    POLYMER, REAGENT LAYER, AND SENSOR
    1.
    发明公开
    POLYMER, REAGENT LAYER, AND SENSOR 审中-公开

    公开(公告)号：US20240141404A1

    公开(公告)日：2024-05-02

    申请号：US18394118

    申请日：2023-12-22

    申请人： PHC Holdings Corporation

    发明人： Keigo HANEDA

    IPC分类号： C12Q1/00

    CPC分类号： C12Q1/004 ,  C12Q1/006

    摘要： A polymer included in a reagent layer of a sensor for measuring an analyte in a sample includes: a first binding site covalently bonded to a protein acting on the analyte; and a second binding site that binds to the protein by electrostatic interaction.

    BIOSENSOR
    2.
    发明申请
    BIOSENSOR 审中-公开

    公开(公告)号：US20190017957A1

    公开(公告)日：2019-01-17

    申请号：US16111882

    申请日：2018-08-24

    申请人： PHC HOLDINGS CORPORATION

    发明人： Nobuyuki SHIGETOU ,  Keigo HANEDA ,  Shingo OOTANI

    IPC分类号： G01N27/327 ,  G01N33/72 ,  G01N27/49

    摘要： A biosensor includes a base substrate; an electrode layer disposed on a main surface of the base substrate and including first and second electrode pairs, each pair including a working electrode and a counter electrode; a spacer substrate on the electrode layer and having first and openings, the first opening exposing a part of the first electrode pair and the second opening exposing a part of the second electrode pair; a first reagent layer containing a first reagent reactive with a sample and disposed in the first opening; a second reagent layer containing a second reagent reactive with the sample and disposed in the second opening; and a top cover substrate on the spacer substrate, the top cover substrate including an introduction portion having at least one introduction opening, the introduction portion overlapping a part of the first opening in the spacer substrate and a part of the second opening.

    BIOLOGICAL SUBSTANCE DETECTION SENSOR
    3.
    发明申请
    BIOLOGICAL SUBSTANCE DETECTION SENSOR 有权

    公开(公告)号：US20210055250A1

    公开(公告)日：2021-02-25

    申请号：US17040127

    申请日：2019-01-25

    申请人： PHC Holdings Corporation

    发明人： Keigo HANEDA ,  Nao HAYASHINO

    IPC分类号： G01N27/327 ,  C12Q1/32

    摘要： Provided is a biological substance detection sensor used in an electrochemical measurement method and allowing high-precision measurement by reducing a blank current. A biological substance detection sensor of the present invention for analyzing a component in a testing solution using a mediator includes at least: an insulating substrate; a conductive part formed on a surface of the insulating substrate and including at least one pair of a working electrode and a counter electrode; and a reagent part disposed in contact with or in a vicinity of the conductive part and including at least one of protein and the mediator. The reagent part further includes at least one additive selected from the group consisting of a halide and/or a pseudo halide.

    HIGH MOLECULAR WEIGHT REDOX POLYMER AND BIOSENSOR USING SAME
    5.
    发明申请
    HIGH MOLECULAR WEIGHT REDOX POLYMER AND BIOSENSOR USING SAME 有权

    公开(公告)号：US20220322978A1

    公开(公告)日：2022-10-13

    申请号：US17764842

    申请日：2019-09-30

    申请人： PHC Holdings Corporation

    发明人： Keigo HANEDA ,  Kazuaki EDAGAWA ,  Fumihisa KITAWAKI

    IPC分类号： A61B5/1486 ,  C12Q1/32 ,  A61B5/145

    摘要： The present disclosure provides a means for preventing or suppressing the leaching of a redox mediator constituting a reagent layer in a probe of an embedded biosensor, in particular, a means capable of improving preservation stability (durability) while maintaining glucose measurement sensitivity. The high molecular weight redox polymer according to the present disclosure is represented by general formula (A1), wherein X− represents an anionic species; L represents a linker; Poly represents a high molecular weight polymer; and R1 to R8 each independently represent a hydrogen atom or a substituent. The biosensor according to the present disclosure has a working electrode, a counter electrode, a reagent layer disposed on the working electrode, and a protective film covering at least the reagent layer, and the reagent layer contains an oxidoreductase that oxidizes or dehydrogenates the analyte and at least one high molecular weight redox polymer represented by general formula (A1).