公开(公告)号：US20250043298A1

公开(公告)日：2025-02-06

申请号：US18722473

申请日：2022-12-15

Applicant: PHILIP MORRIS PRODUCTS S.A.

Inventor： Lucien BOVET ,  Aurore HILFIKER ,  Nikolai IVANOV ,  Kacper Piotr KAMINSKI

IPC: C12N15/82 ,  A24B13/00 ,  A24B15/10

Abstract: There is disclosed a mutant, non-naturally occurring or transgenic Nicotiana plant leaf, part of the plant leaf and/or stem having reduced expression or activity of methyl putrescine oxidase (MPO)-S and MPO-T, wherein the MPO-S comprises, consists or consists essentially of: (i) a polynucleotide sequence comprising, consisting or consisting essentially of a sequence having at least 75% sequence identity to SEQ ID NO: 1; or (ii) a polypeptide encoded by the polynucleotide set forth in (i); or (iii) a polypeptide having at least 75% sequence identity to SEQ ID NO: 2; and wherein the MPO-T comprises, consists or consists essentially of: (iv) a polynucleotide sequence comprising, consisting or consisting essentially of a sequence having at least 75% sequence identity to SEQ ID NO: 3; or (v) a polypeptide encoded by the polynucleotide set forth in (iv); or (vi) a polypeptide having at least 75% sequence identity to SEQ ID NO: 4; and wherein the expression or activity of the MPO-S set forth in (i), (ii) or (iii), and the MPO-T set forth in (iv), (v) or (vi) are reduced as compared to a control plant.

公开(公告)号：US20220400674A1

公开(公告)日：2022-12-22

申请号：US17622001

申请日：2020-06-24

Applicant: Philip Morris Products S.A.

Inventor： Julia HOENG ,  Nikolai IVANOV ,  Kacper KAMINSKI ,  Anatoly MAZUROV ,  Sandra SCHORDERET WEBER

IPC: A01N43/40 ,  A01N65/38 ,  A01P17/00

Abstract: A formulation containing an extract of a tobacco plant enriched for a compound of formula (I), or a salt or crystal thereof, where the formulation is used for reducing the infestation of ectoparasites: where
R represents hydrogen or C1-C5 alkyl, and represents a double bond.

公开(公告)号：US20240385186A1

公开(公告)日：2024-11-21

申请号：US18683643

申请日：2022-08-15

Applicant: Philip Morris Products S.A.

Inventor： Laura FRANCIUS ,  Nikolai IVANOV ,  Maxime LAROCHE ,  Thibaut PELAT ,  Marja TALIKKA

IPC: G01N33/543 ,  C07K16/44 ,  G01N33/58 ,  G01N33/94

Abstract: There is disclosed an antibody or antigen binding fragment thereof: (i) capable of binding to N-acetyl-S—[2-carboxyethyl]-L-cysteine (CEMA) and; (ii) capable of binding to a conjugate comprising a compound of formula [II] wherein n is selected from 0 to 4 (that is, 0, 1, 2, 3, or 4), and each R is independently selected from H or C1 to C6 alkyl; preferably, a compound of formula [I] wherein the compound of formula [II] or formula [I] is coupled to an immunogenic carrier via a linker, suitably, wherein the linker is coupled to the compound of formula [I] via the amine group.

公开(公告)号：US20230225323A1

公开(公告)日：2023-07-20

申请号：US18002403

申请日：2021-06-23

Applicant: Philip Morris Products S.A.

Inventor： Julia HOENG ,  Nikolai IVANOV ,  Kacper KAMINSKI ,  Anatoly MAZUROV ,  Sandra SCHORDERET WEBER

IPC: A01N43/90 ,  C07D401/12 ,  C07D487/08 ,  C07D401/04 ,  C07D401/14 ,  A01N43/40 ,  C07D453/06 ,  A01P17/00

CPC classification number: A01N43/90 ,  C07D401/12 ,  C07D487/08 ,  C07D401/04 ,  C07D401/14 ,  A01N43/40 ,  C07D453/06 ,  A01P17/00

Abstract: A compound of Formula I and formulations including such a compound may be used for the reduction of infestation with ectoparasites, in particular ectoparasites of the insect class, including fleas and mosquitoes, and/or ectoparasites of the arachnid class, including ticks and mites, etc. Methods for controlling ectoparasites and/or formulations including such compounds may include use as a repellent, and/or application to a mammal, e.g., a human, dog, cat, cattle, horse, or sheep, or to an object or a fabric. The form may be a topical formulation, a shampoo composition, a cleansing composition, or a treatment composition, preferably a lotion, cream, ointment, gel, foam, patch, powder, solid, sponge, tape, vapor, paste, tincture, or spray.