专利检索 ap:("PIRAMAL ENTERPRISES LIMITED") AND inv:"Nainesh Kansagara" 第 1 页

1.

发明授权
Process for the preparation of vortioxetine and salts thereof 有权

公开(公告)号：US10428033B2

公开(公告)日：2019-10-01

申请号：US15896193

申请日：2018-02-14

申请人： PIRAMAL ENTERPRISES LIMITED

发明人： Milind Gharpure , Sanjay Kumar Sharma , Nainesh Kansagara

IPC分类号： C07D295/096 , C07B43/04 , C07C211/46

摘要： The present invention provides an improved process for preparation of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine; commonly known as vortioxetine (referred to as the compound (I)) and pharmaceutically acceptable salts thereof; wherein the process comprises reaction of 2-((2,4-dimethylphenyl)thio)aniline (II) with bis(2-alkyl)amine (IIIa) or its salt in the presence of a cyclic amide solvent.

2.

发明申请
PROCESS FOR THE PREPARATION OF VORTIOXETINE AND SALTS THEREOF 审中-公开

公开(公告)号：US20180230116A1

公开(公告)日：2018-08-16

申请号：US15896193

申请日：2018-02-14

申请人： PIRAMAL ENTERPRISES LIMITED

发明人： Milind Gharpure , Sanjay Kumar Sharma , Nainesh Kansagara

IPC分类号： C07D295/096 , C07C211/46 , C07B43/04

CPC分类号： C07D295/096 , C07B43/04 , C07C211/46

摘要： The present invention provides an improved process for preparation of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine; commonly known as vortioxetine (referred to as the compound (I)) and pharmaceutically acceptable salts thereof; wherein the process comprises reaction of 2-((2,4-dimethylphenyl)thio)aniline (II) with bis(2-alkyl)amine (IIIa) or its salt in the presence of a cyclic amide solvent.