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公开(公告)号：US10428033B2
公开(公告)日：2019-10-01
申请号：US15896193
申请日：2018-02-14
IPC分类号： C07D295/096 , C07B43/04 , C07C211/46
摘要： The present invention provides an improved process for preparation of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine; commonly known as vortioxetine (referred to as the compound (I)) and pharmaceutically acceptable salts thereof; wherein the process comprises reaction of 2-((2,4-dimethylphenyl)thio)aniline (II) with bis(2-alkyl)amine (IIIa) or its salt in the presence of a cyclic amide solvent.
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公开(公告)号：US20180230116A1
公开(公告)日：2018-08-16
申请号：US15896193
申请日：2018-02-14
IPC分类号： C07D295/096 , C07C211/46 , C07B43/04
CPC分类号： C07D295/096 , C07B43/04 , C07C211/46
摘要： The present invention provides an improved process for preparation of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine; commonly known as vortioxetine (referred to as the compound (I)) and pharmaceutically acceptable salts thereof; wherein the process comprises reaction of 2-((2,4-dimethylphenyl)thio)aniline (II) with bis(2-alkyl)amine (IIIa) or its salt in the presence of a cyclic amide solvent.
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公开(公告)号：US11198703B2
公开(公告)日：2021-12-14
申请号：US16612028
申请日：2018-05-09
摘要： The present invention relates to an industrially feasible and economically viable process for preparation of Bexagliflozin of formula V in significantly high yield and purity.
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