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公开(公告)号：US20240309000A1
公开(公告)日：2024-09-19
申请号：US18672343
申请日：2024-05-23
发明人： Jian Zhu , Mohammad R. Masjedizadeh
IPC分类号： C07D471/04 , A61P35/00 , C07B35/02 , C07B35/06 , C07B39/00 , C07B43/04 , C07B43/06 , C07B45/04
CPC分类号： C07D471/04 , A61P35/00 , C07B35/02 , C07B35/06 , C07B39/00 , C07B43/04 , C07B43/06 , C07B45/04 , C07B2200/13
摘要： Disclosed herein are processes for preparing 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one and FGFR inhibitor, as well as polymorphs and/or salt forms thereof.
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公开(公告)号：US20190241589A1
公开(公告)日：2019-08-08
申请号：US16284841
申请日：2019-02-25
IPC分类号： C07F15/00 , C07C17/32 , C07D215/38 , C07D307/46 , C07D213/56 , C07D213/50 , C07D213/24 , C07D213/127 , C07D295/096 , C07D471/04 , C07D409/04 , C07D405/04 , C07D403/04 , C07D401/06 , C07B43/04 , C07B37/04 , C07C45/68
CPC分类号： C07F15/006 , C07B37/04 , C07B43/04 , C07C17/32 , C07C45/68 , C07D213/127 , C07D213/24 , C07D213/50 , C07D213/56 , C07D215/38 , C07D295/096 , C07D307/46 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04 , C07D471/04 , C07C49/84 , C07C22/08
摘要： The present invention provides a palladium(II) complex of formula (1) or a palladium(II) complex of formula (2). R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R18, R19, R20, R21, R22, R23 and R24, m, E and X are described in the specification.The invention also provides a process for the preparation of the complexes, and their use in carbon-carbon and carbon-heteroatom coupling reactions.
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公开(公告)号：US20180370943A1
公开(公告)日：2018-12-27
申请号：US16017106
申请日：2018-06-25
IPC分类号： C07D321/00 , C07D245/04 , C07B41/04 , C07B43/04
CPC分类号： C07D321/00 , C07B41/04 , C07B43/04 , C07B2200/07 , C07D245/04
摘要： Provided herein are cyclodecynes, including chiral cyclodecynes, and methods of making cyclodecynes. The methods may include providing a 1,1′-biaryl compound substituted independently at the 2-position and the 2′-position with a hydroxyl or an amino group; and contacting the 1,1′-biaryl compound with a protected but-2-yne-1,4-diol to form the cyclodecyne.
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公开(公告)号：US20180215756A1
公开(公告)日：2018-08-02
申请号：US15748212
申请日：2016-08-10
发明人： Jiang ZHU , Mohammad MASJEDIZADEH
IPC分类号： C07D471/04 , C07B35/02 , C07B35/06 , C07B39/00 , C07B43/04 , C07B43/06 , C07B45/04 , A61P35/00
CPC分类号： C07D471/04 , A61P35/00 , C07B35/02 , C07B35/06 , C07B39/00 , C07B43/04 , C07B43/06 , C07B45/04 , C07B2200/13
摘要： Disclosed herein are processes for preparing 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one and FGFR inhibitor, as well as polymorphs and/or salt forms thereof.
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公开(公告)号：US20170210695A1
公开(公告)日：2017-07-27
申请号：US15515071
申请日：2015-10-08
IPC分类号： C07C209/18 , C07D213/74 , C07D317/66 , C07C213/02 , B01J31/22 , C07C221/00 , C07C253/30 , C07D295/023 , C07B43/04 , C07C231/12 , C07C227/08
CPC分类号： C07C209/18 , B01J31/2295 , B01J2231/44 , B01J2531/824 , C07B43/04 , C07C209/66 , C07C213/02 , C07C221/00 , C07C227/08 , C07C231/12 , C07C253/30 , C07D213/74 , C07D295/023 , C07D295/033 , C07D317/58 , C07D317/66 , C07C211/54 , C07C211/48 , C07C211/55 , C07C211/56 , C07C223/06 , C07C237/40 , C07C217/84 , C07C229/60 , C07C255/58
摘要： The present disclosure describes a method of coupling a first compound to a second compound, the method comprising: providing the first compound having a fluorosulfonate substituent; providing the second compound comprising an amine; and reacting the first compound and the second compound in a reaction mixture, the reaction mixture including a catalyst having at least one group 10 atom, the reaction mixture under conditions effective to couple the first compound to the second compound. The present disclosure further describes a one-pot method for coupling a first compound to a second compound.
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公开(公告)号：US20170107251A1
公开(公告)日：2017-04-20
申请号：US15355082
申请日：2016-11-18
发明人： David MILSTEIN , Ekambaram Balaraman , Chidambaram Gunanathan , Boopathy Gnanaprakasam , Jing Zhang
IPC分类号： C07K5/12 , C07C209/62 , C07D305/06 , C07D307/44 , C07C29/149 , C07D295/027 , C07D207/06 , C07D207/08 , C07D211/12 , C07C231/10 , C07D307/52 , C07D295/185 , C07C67/00 , C07C213/02 , C07C51/00 , C07D309/30 , C07D307/33 , C07D307/83 , C07C67/297 , C07D241/12 , C07B41/02 , C07B43/04 , C07B41/08 , C07B41/12 , C07B43/06 , B01J31/24 , C07C41/26
CPC分类号： C07K5/12 , B01J31/18 , B01J31/189 , B01J31/2404 , B01J31/2409 , B01J31/248 , B01J31/2485 , B01J2231/40 , B01J2231/49 , B01J2231/643 , B01J2231/763 , B01J2531/0244 , B01J2531/821 , C07B41/02 , C07B41/08 , C07B41/12 , C07B43/04 , C07B43/06 , C07C29/136 , C07C29/149 , C07C29/177 , C07C41/16 , C07C41/26 , C07C45/002 , C07C45/006 , C07C51/00 , C07C51/02 , C07C51/23 , C07C51/295 , C07C67/00 , C07C67/03 , C07C67/297 , C07C209/00 , C07C209/62 , C07C213/00 , C07C213/02 , C07C231/02 , C07C231/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D207/06 , C07D207/08 , C07D211/12 , C07D213/38 , C07D241/08 , C07D241/12 , C07D295/023 , C07D295/027 , C07D295/185 , C07D305/06 , C07D307/14 , C07D307/33 , C07D307/44 , C07D307/52 , C07D307/83 , C07D309/30 , C07D487/14 , C07F9/58 , C07F9/65583 , C07F15/0046 , C07F15/0053 , C07K1/00 , C08G69/00 , Y02P20/52 , C07C233/05 , C07C235/06 , C07C233/07 , C07C235/16 , C07C235/14 , C07C235/10 , C07C211/27 , C07C211/07 , C07C211/35 , C07C211/46 , C07C211/10 , C07C215/28 , C07C217/58 , C07C69/14 , C07C69/24 , C07C31/125 , C07C31/12 , C07C49/78 , C07C49/04 , C07C49/10 , C07C49/08 , C07C49/403 , C07C31/205 , C07C31/202 , C07C31/04 , C07C31/08 , C07C33/20 , C07C33/22 , C07C31/1355 , C07C31/10 , C07C43/13 , C07C69/78 , C07C69/75 , C07C53/124 , C07C53/126 , C07C59/125 , C07C57/32 , C07C61/08 , C07C57/30 , C07C65/21 , C07C63/08 , C07C63/06
摘要： The present invention relates to novel Ruthenium complexes and related borohydride complexes, and their use for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including preparing polyamides (e.g., polypeptides) by reacting dialcohols and diamines or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones), cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to novel uses of certain pyridine Ruthenium complexes.
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公开(公告)号：US09505714B2
公开(公告)日：2016-11-29
申请号：US14910275
申请日：2014-08-06
IPC分类号： C07C45/00 , C07C395/00 , C07C1/00 , C07C209/00 , C07C319/00 , C07F7/00 , C07C391/00 , C07C1/32 , C07C319/02 , C07C319/14 , C07C17/093 , C07B39/00 , C07B41/06 , C07B43/04 , C07B45/00 , C07B47/00 , C07C209/22 , C07C231/10 , C07F7/22 , C07F9/50
CPC分类号： C07C395/00 , C07B39/00 , C07B41/06 , C07B43/04 , C07B45/00 , C07B47/00 , C07C1/321 , C07C17/093 , C07C45/00 , C07C209/22 , C07C231/10 , C07C319/02 , C07C319/14 , C07C391/00 , C07F7/2208 , C07F9/5004 , C07C321/04 , C07C321/14 , C07C11/02
摘要： The invention provides processes and materials for the efficient and costeffective functionalization of alkanes and heteroalkanes, comprising contacting the alkane or heteroalkane and a soft oxidizing electrophile comprising Se(VI) or Te(VI), in an acidic medium, optionally further comprising an aprotic medium, which can be carried out at a temperature of less than 300 C. Isolation of the alkylselenium or alkyltellurium intermediate allows the subsequent conversion to products not necessarily compatible with the initial reaction conditions, such as amines, stannanes, organosulfur compounds, acyls, halocarbons, and olefins.
摘要翻译： 本发明提供用于烷烃和杂烷烃的有效和成本有效的功能化的方法和材料，包括在酸性介质中使烷烃或杂烷烃与包含Se（VI）或Te（VI）的软氧化亲电试剂接触，任选地还包含非质子介质 可以在小于300℃的温度下进行。烷基硒或烷基碲中间体的分离允许随后转化成与初始反应条件不一致的产物，例如胺，锡烷，有机硫化合物，酰基，卤代烃， 和烯烃。
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公开(公告)号：US20160176812A1
公开(公告)日：2016-06-23
申请号：US14910275
申请日：2014-08-06
IPC分类号： C07C395/00 , C07C209/22 , C07F7/22 , C07C319/02 , C07C231/10 , C07F9/50 , C07C45/00 , C07C17/093 , C07B47/00 , C07B45/00 , C07B43/04 , C07B41/06 , C07B39/00 , C07C1/32 , C07C391/00
CPC分类号： C07C395/00 , C07B39/00 , C07B41/06 , C07B43/04 , C07B45/00 , C07B47/00 , C07C1/321 , C07C17/093 , C07C45/00 , C07C209/22 , C07C231/10 , C07C319/02 , C07C319/14 , C07C391/00 , C07F7/2208 , C07F9/5004 , C07C321/04 , C07C321/14 , C07C11/02
摘要： The invention provides processes and materials for the efficient and costeffective functionalization of alkanes and heteroalkanes, comprising contacting the alkane or heteroalkane and a soft oxidizing electrophile comprising Se(VI) or Te(VI), in an acidic medium, optionally further comprising an aprotic medium, which can be carried out at a temperature of less than 300 C. Isolation of the alkylselenium or alkyltellurium intermediate allows the subsequent conversion to products not necessarily compatible with the initial reaction conditions, such as amines, stannanes, organosulfur compounds, acyls, halocarbons, and olefins.
摘要翻译： 本发明提供用于烷烃和杂烷烃的有效和成本有效的功能化的方法和材料，包括在酸性介质中使烷烃或杂烷烃与包含Se（VI）或Te（VI）的软氧化亲电试剂接触，任选地还包含非质子介质 可以在小于300℃的温度下进行。烷基硒或烷基碲中间体的分离允许随后转化成与初始反应条件不一致的产物，例如胺，锡烷，有机硫化合物，酰基，卤代烃， 和烯烃。
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公开(公告)号：US20150232412A1
公开(公告)日：2015-08-20
申请号：US14426221
申请日：2013-09-05
申请人： Dexlechem GMBH
IPC分类号： C07C209/32 , C07B43/04 , C07C221/00 , C07C227/04 , C07C213/02 , C07C231/12
CPC分类号： C07C209/325 , C07B43/04 , C07C209/34 , C07C209/365 , C07C213/02 , C07C221/00 , C07C227/04 , C07C231/12 , C07C211/03 , C07C215/08 , C07C229/08 , C07C211/52 , C07C215/68 , C07C217/84 , C07C217/86 , C07C233/43 , C07C225/22 , C07C223/06 , C07C229/60
摘要： Disclosed is a novel process for the reduction of nitro groups to amino derivatives, based on the use of trichlorosilane and an organic base, which is efficient from the chemical standpoint and of wide general applicability.
摘要翻译： 公开了一种基于三氯硅烷和有机碱的使用将硝基还原为氨基衍生物的新方法，其从化学观点和广泛的普遍适用性是有效的。
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公开(公告)号：US09012690B2
公开(公告)日：2015-04-21
申请号：US13825449
申请日：2011-09-01
申请人： Osamu Ogata , Wataru Kuriyama , Takaji Matsumoto
发明人： Osamu Ogata , Wataru Kuriyama , Takaji Matsumoto
IPC分类号： C07C209/00 , C07C209/50 , C07B41/02 , C07B43/04 , C07C29/149 , C07C209/62 , C07D295/18 , C07C29/36 , C07D295/02
CPC分类号： C07C209/50 , B01J31/1805 , B01J31/189 , B01J31/20 , B01J31/24 , B01J2231/643 , B01J2531/821 , C07B41/02 , C07B43/04 , C07C29/149 , C07C29/36 , C07C209/62 , C07D295/02 , C07D295/18 , C07C211/04 , C07C211/46 , C07C211/48 , C07C211/55 , C07C31/125 , C07C33/22
摘要： Disclosed herein is a method for producing an alcohol and an amine from an amide under an atmosphere of hydrogen with the use of, as a catalyst, a ruthenium complex that is easily prepared, easy to handle, and relatively cheaply obtained. Specifically, the method is a method for producing an alcohol and/or an amine from an amide compound under an atmosphere of hydrogen with the use of as a catalyst, a ruthenium carbonyl complex represented by the following general formula (1): RuXY(CO)(L) (1) wherein X and Y may be the same or different from each other and each represents an anionic ligand and L represents a tridentate aminodiphosphine ligand containing two phosphino groups and a —NH— group.
摘要翻译： 本文公开了一种在氢气氛下由酰胺制备醇和胺的方法，其中使用易于制备，易于处理和相对便宜地获得的钌络合物作为催化剂。 具体地说，该方法是使用作为催化剂的氢气气氛下的酰胺化合物制备醇和/或胺的方法，由以下通式（1）表示的羰基钌络合物：RuXY（CO ）（L）（1）其中X和Y可以相同或不同，各自表示阴离子配体，L表示含有两个膦基和-NH-基团的三齿氨基二膦配体。
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