公开(公告)号：US20150150994A1

公开(公告)日：2015-06-04

申请号：US14401922

申请日：2013-05-21

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang Hahn ,  Min Young Lee ,  Jeonga Yang ,  Ho Sang Jung

IPC: A61K47/48 ,  A61K38/21

CPC classification number: A61K38/212 ,  A61K38/177 ,  A61K38/1833 ,  A61K47/61 ,  A61K47/6923

Abstract: The present invention relates to liver targeted drug delivery system using metal nanoparticles and a method for preparing the same. More particularly, the present invention relates to a method for preparing hyaluronic acid-gold nanoparticles/protein complex that can be used as liver targeted drug delivery system, by surface modifying gold nanoparticles having excellent stability in the body with hyaluronic acid having biocompatibility, biodegradability and liver tissue-specific delivery property, and binding protein drugs for treating liver diseases to the non-modified surface of the gold nanoparticles. And, the present invention relates to use of the hyaluronic acid-gold nanoparticles/protein complex for liver disease drug that may be safely applied to human body, increase drug efficacy duration time, and be effectively delivered to liver.

Abstract translation: 本发明涉及使用金属纳米粒子的肝靶向药物递送系统及其制备方法。 更具体地说，本发明涉及一种可用作肝靶向药物递送系统的透明质酸 - 金纳米粒子/蛋白质复合物的制造方法，其通过用具有生物相容性，生物可降解性的透明质酸在人体内表现出优异稳定性的金纳米颗粒， 肝组织特异性递送性质和用于治疗肝脏疾病的结合蛋白药物到金纳米颗粒的未改性表面。 而且，本发明涉及透明质酸 - 金纳米粒子/蛋白质复合物在肝脏疾病药物中的应用，其可以安全地应用于人体，增加药物疗效持续时间，并且有效地输送到肝脏。

公开(公告)号：US20160243246A1

公开(公告)日：2016-08-25

申请号：US15151632

申请日：2016-05-11

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Kitae Park ,  Jeonga Yang ,  Won Ho Kong ,  Min Young Lee

IPC: A61K47/48 ,  A61K31/713

CPC classification number: A61K47/61 ,  A61K31/713 ,  A61K31/728

Abstract: The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.

Abstract translation: 本发明涉及用于开发体内核酸递送系统的透明质酸 - 核酸缀合物，以及使用其的核酸递送系统的开发。 具体地，其中透明质酸 - 亚烷基二胺缀合物和核酸通过二硫键连接的透明质酸 - 核酸复合物; 用于核酸递送的组合物，其包含透明质酸 - 核酸复合物作为活性成分; 一种制备透明质酸 - 核酸复合物的方法; 以及包括对受试者施用透明质酸 - 核酸复合物的体内递送核酸的方法。

公开(公告)号：US20140080897A1

公开(公告)日：2014-03-20

申请号：US14027391

申请日：2013-09-16

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Kitae Park ,  Jeonga Yang ,  Won Ho Kong ,  Min Young Lee

IPC: A61K47/48 ,  A61K31/7088

CPC classification number: A61K47/61 ,  A61K31/713 ,  A61K31/728

Abstract: The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.

Abstract translation: 本发明涉及用于开发体内核酸递送系统的透明质酸 - 核酸缀合物，以及使用其的核酸递送系统的开发。 具体地，其中透明质酸 - 亚烷基二胺缀合物和核酸通过二硫键连接的透明质酸 - 核酸复合物; 用于核酸递送的组合物，其包含透明质酸 - 核酸复合物作为活性成分; 一种制备透明质酸 - 核酸复合物的方法; 以及包括对受试者施用透明质酸 - 核酸复合物的体内递送核酸的方法。