公开(公告)号：US20160243246A1

公开(公告)日：2016-08-25

申请号：US15151632

申请日：2016-05-11

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Kitae Park ,  Jeonga Yang ,  Won Ho Kong ,  Min Young Lee

IPC: A61K47/48 ,  A61K31/713

CPC classification number: A61K47/61 ,  A61K31/713 ,  A61K31/728

Abstract: The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.

Abstract translation: 本发明涉及用于开发体内核酸递送系统的透明质酸 - 核酸缀合物，以及使用其的核酸递送系统的开发。 具体地，其中透明质酸 - 亚烷基二胺缀合物和核酸通过二硫键连接的透明质酸 - 核酸复合物; 用于核酸递送的组合物，其包含透明质酸 - 核酸复合物作为活性成分; 一种制备透明质酸 - 核酸复合物的方法; 以及包括对受试者施用透明质酸 - 核酸复合物的体内递送核酸的方法。

公开(公告)号：US20140080897A1

公开(公告)日：2014-03-20

申请号：US14027391

申请日：2013-09-16

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Kitae Park ,  Jeonga Yang ,  Won Ho Kong ,  Min Young Lee

IPC: A61K47/48 ,  A61K31/7088

CPC classification number: A61K47/61 ,  A61K31/713 ,  A61K31/728

Abstract: The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.

Abstract translation: 本发明涉及用于开发体内核酸递送系统的透明质酸 - 核酸缀合物，以及使用其的核酸递送系统的开发。 具体地，其中透明质酸 - 亚烷基二胺缀合物和核酸通过二硫键连接的透明质酸 - 核酸复合物; 用于核酸递送的组合物，其包含透明质酸 - 核酸复合物作为活性成分; 一种制备透明质酸 - 核酸复合物的方法; 以及包括对受试者施用透明质酸 - 核酸复合物的体内递送核酸的方法。