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公开(公告)号：US20230096841A1
公开(公告)日：2023-03-30
申请号：US17987391
申请日：2022-11-15
Applicant: POSCO , POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Sei Kwang HAHN , Seulgi HAN , Hyun Woo LEE , Kyoo KIM
IPC: A61K41/00 , C09K11/77 , A61K47/69 , A61N5/06 , C09K11/02 , A61K8/02 , A61K8/19 , A61Q1/02 , A61K8/73
Abstract: An upconversion nanoparticle includes at least one host selected from LiYF4, NaY, NaYF4, NaGdF4, and CaF3, at least one sensitizer selected from Sm3+, Nd3+, Dy3+, Ho3+, and Yb3+ doped in the at least one host, and at least one activator selected from Er3+, Ho3+, Tm3+, and Eu3+ doped in the at least one host. The upconversion nanoparticle is designed using a calculation from first principles to absorb light in the near-infrared wavelength range whose stability is ensured. Further, a hyaluronic acid-upconversion nanoparticle conjugate, in which the upconversion nanoparticle as described above is bonded to hyaluronic acid, is provided to be used in various internal sites with a hyaluronic acid receptor, particularly enables targeting, and increases an internal retention period and biocompatibility thereof.
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公开(公告)号：US20180036974A1
公开(公告)日：2018-02-08
申请号：US15522816
申请日：2016-04-25
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Sei Kwang HAHN , Young Chul SUNG , Beom Ho MUN , Keon Jae LEE , Dohee KEUM , Su Jin KIM
CPC classification number: B29D11/00096 , A61B5/14532 , A61B5/4839 , A61B5/6821 , A61F9/0017 , A61K9/0048 , A61K39/395 , A61M37/00 , G01N33/528 , G01N33/5438 , G01N33/66 , G01N2800/164 , G02B2027/0178 , G02C7/04 , G02C7/085 , G02C7/086
Abstract: The present invention provides a smart contact lens including a sensor capable of non-invasively sensing an eye disease in real time and a drug reservoir, and smart glasses for controlling the smart contact lens.
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3.发明申请HYALURONIC ACID DERIVATIVES AND COMPOSITION FOR CELL-SURFACE ENGINEERING USING THE SAME 审中-公开丙烯酸衍生物及其组合物用于细胞表面工程公开(公告)号：US20170067012A1
公开(公告)日：2017-03-09
申请号：US15249285
申请日：2016-08-26
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Sei Kwang HAHN , Yun seop KIM , Won Ho KONG , Hyemin KIM
CPC classification number: C12N5/0006 , C08B37/0072
Abstract: Provided are a hyaluronic acid derivative for liver-targeting delivery via intravenous injection of cells and a preparation method thereof. More particularly, provided are a preparation method of a hyaluronic acid derivative capable of modifying the surface of cells and also having biocompatibility, biodegradability, and liver-targeting deliver property, and use of the hyaluronic acid derivative prepared thereby as a liver-targeting cell delivery system.
Abstract translation: 提供通过静脉内注射细胞用于肝靶向递送的透明质酸衍生物及其制备方法。 更具体地，提供了能够改变细胞表面并且还具有生物相容性，生物可降解性和肝靶向递送性的透明质酸衍生物的制备方法，以及由此制备的透明质酸衍生物作为肝靶向细胞递送的用途 系统。
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4.发明申请MICRO-NEEDLE AND SENSOR FOR DETECTING NITROGEN MONOOXIDE COMPRISING THE SAME 审中-公开用于检测包含其的含氮单体的微针和传感器公开(公告)号：US20160174885A1
公开(公告)日：2016-06-23
申请号：US14855727
申请日：2015-09-16
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Sei Kwang HAHN , Dohee KEUM , Ho Sang JUNG , Hyemin KIM , Myeong Hwan SHIN
IPC: A61B5/145 , A61B5/1473
CPC classification number: A61B5/14542 , A61B5/14528 , A61B5/1473 , A61B2562/028
Abstract: The present invention relates to a microneedle, a sensor for detecting nitrogen monoxide, including the microneedle, a medical apparatus including the microneedle, and a manufacturing method thereof. The microneedle of the present invention may detect whether nitrogen monoxide is present or not by using electrochemical principles. Further, a change in concentration of nitrogen monoxide may be sensed in real time. The effects of detecting nitrogen monoxide may be used to diagnose cancer and forecast the size and growth degree of a tumor.
Abstract translation: 本发明涉及一种微针，包括微针检测一氧化氮的传感器，包括该微针的医疗装置及其制造方法。 本发明的微针可以通过使用电化学原理来检测是否存在一氧化氮。 此外，可以实时检测一氧化氮浓度的变化。 检测一氧化氮的效果可用于诊断癌症并预测肿瘤的大小和生长程度。
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公开(公告)号：US20200276309A1
公开(公告)日：2020-09-03
申请号：US16783548
申请日：2020-02-06
Applicant: POSCO , POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Sei Kwang HAHN , Seulgi HAN , Hyun Woo LEE , Kyoo KIM
IPC: A61K41/00 , C09K11/77 , A61K47/69 , A61N5/06 , C09K11/02 , A61K8/02 , A61K8/19 , A61Q1/02 , A61K8/73
Abstract: An upconversion nanoparticle includes at least one host selected from LiYF4, NaY, NaYF4, NaGdF4, and CaF3, at least one sensitizer selected from Sm3+, Nd3+, Dy3+, Ho3+, and Yb3+ doped in the at least one host, and at least one activator selected from Er3+, Ho3+, Tm3+, and Eu3+ doped in the at least one host. The upconversion nanoparticle is designed using a calculation from first principles to absorb light in the near-infrared wavelength range whose stability is ensured. Further, a hyaluronic acid-upconversion nanoparticle conjugate, in which the upconversion nanoparticle as described above is bonded to hyaluronic acid, is provided to be used in various internal sites with a hyaluronic acid receptor, particularly enables targeting, and increases an internal retention period and biocompatibility thereof.
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Patent Agency Ranking
公开(公告)号：US20190076526A1
公开(公告)日：2019-03-14
申请号：US15703194
申请日：2017-09-13
Applicant: POSCO , POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Sei Kwang HAHN , Seulgi HAN , Hyun Woo LEE , Kyoo KIM
Abstract: An upconversion nanoparticle includes at least one host selected from LiYF4, NaY, NaYF4, NaGdF4, and CaF3, at least one sensitizer selected from Sm3+, Nd3+, Dy3+, Ho3+, and Yb3+ doped in the at least one host, and at least one activator selected from Er3+, Ho3+, Tm3+, and Eu3+ doped in the at least one host. The upconversion nanoparticle is designed using a calculation from first principles to absorb light in the near-infrared wavelength range whose stability is ensured. Further, a hyaluronic acid-upconversion nanoparticle conjugate, in which the upconversion nanoparticle as described above is bonded to hyaluronic acid, is provided to be used in various internal sites with a hyaluronic acid receptor, particularly enables targeting, and increases an internal retention period and biocompatibility thereof.
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7.发明申请HYALURONIC ACID-NUCLEIC ACID CONJUGATE AND COMPOSITION FOR NUCLEIC ACID DELIVERY CONTAINING THE SAME 审中-公开含羟基酸的核酸结合物及其含有核酸的交联组合物公开(公告)号：US20160243246A1
公开(公告)日：2016-08-25
申请号：US15151632
申请日：2016-05-11
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Sei Kwang HAHN , Kitae Park , Jeonga Yang , Won Ho Kong , Min Young Lee
IPC: A61K47/48 , A61K31/713
CPC classification number: A61K47/61 , A61K31/713 , A61K31/728
Abstract: The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.
Abstract translation: 本发明涉及用于开发体内核酸递送系统的透明质酸 - 核酸缀合物，以及使用其的核酸递送系统的开发。 具体地，其中透明质酸 - 亚烷基二胺缀合物和核酸通过二硫键连接的透明质酸 - 核酸复合物; 用于核酸递送的组合物，其包含透明质酸 - 核酸复合物作为活性成分; 一种制备透明质酸 - 核酸复合物的方法; 以及包括对受试者施用透明质酸 - 核酸复合物的体内递送核酸的方法。
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8.发明申请HYALURONIC ACID-NUCLEIC ACID CONJUGATE AND COMPOSITION FOR NUCLEIC ACID DELIVERY CONTAINING THE SAME 审中-公开含羟基酸的核酸结合物及其含有核酸的交联组合物公开(公告)号：US20140080897A1
公开(公告)日：2014-03-20
申请号：US14027391
申请日：2013-09-16
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Sei Kwang HAHN , Kitae Park , Jeonga Yang , Won Ho Kong , Min Young Lee
IPC: A61K47/48 , A61K31/7088
CPC classification number: A61K47/61 , A61K31/713 , A61K31/728
Abstract: The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.
Abstract translation: 本发明涉及用于开发体内核酸递送系统的透明质酸 - 核酸缀合物，以及使用其的核酸递送系统的开发。 具体地，其中透明质酸 - 亚烷基二胺缀合物和核酸通过二硫键连接的透明质酸 - 核酸复合物; 用于核酸递送的组合物，其包含透明质酸 - 核酸复合物作为活性成分; 一种制备透明质酸 - 核酸复合物的方法; 以及包括对受试者施用透明质酸 - 核酸复合物的体内递送核酸的方法。
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9.发明申请公开(公告)号：US20170274005A1
公开(公告)日：2017-09-28
申请号：US15384434
申请日：2016-12-20
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Sei Kwang HAHN , Songeun Beack , Jun-Sub Choi , Choun-Ki Joo
IPC: A61K31/728 , A61K41/00 , A61K9/00 , A61K33/44
CPC classification number: A61K31/728 , A61K9/0019 , A61K9/0048 , A61K33/44 , A61K41/0071 , A61K47/547 , A61K47/55 , A61K47/61 , A61K47/6923 , A61K47/6929
Abstract: Disclosed is a complex for remedying or treating a retinal disease. The complex includes a hyaluronic acid or a derivative thereof, a carbon nanomaterial covalently bonded to the hyaluronic acid or the derivative thereof, and a photosensitizer bonded to the carbon nanomaterial. The complex for remedying or treating the retinal disease according to the present invention includes a hyaluronic acid-carbon nanomaterial-photosensitizer complex, thus selectively preventing the formation of active oxygen in retinal pigment epithelium cells for a relatively long period of time. Accordingly, the complex has excellent therapeutic efficacy and easily infiltrates into cells. Further, the present invention provides a composition for remedying or treating a retinal disease including the hyaluronic acid-carbon nanomaterial-photosensitizer complex.
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10.发明申请LOW-DENSITY LIPOPROTEIN ANALOGUE NANOPARTICLES, AND COMPOSITION COMPRISING SAME FOR TARGETED DIAGNOSIS AND TREATMENT OF LIVER 审中-公开低密度脂蛋白模拟纳米颗粒，以及包含相同鉴定诊断和治疗肝脏的组合物公开(公告)号：US20150297749A1
公开(公告)日：2015-10-22
申请号：US14430945
申请日：2013-10-02
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Sei Kwang HAHN , Won Ho KONG , Kitae PARK
IPC: A61K47/48 , A61K51/04 , C12N15/113 , A61K51/12
CPC classification number: A61K51/0493 , A61K9/1271 , A61K9/1272 , A61K9/1275 , A61K49/1839 , A61K51/1251 , C12N15/111 , C12N15/1136 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2320/30 , C12N2320/32
Abstract: This disclosure relates to a low density lipoprotein-like cationic solid lipid nanoparticle targeting liver cells including parenchyma cells and non-parenchyma cells, a composition for liver target delivery, a composition for diagnosis and/or treatment of liver disease comprising the same, and a method for liver targeting of an active ingredient.
Abstract translation: 本公开内容涉及靶向肝细胞的低密度脂蛋白样阳离子固体脂质纳米颗粒，包括实质细胞和非实质细胞，用于肝靶标递送的组合物，用于诊断和/或治疗肝病的组合物，其包含该组合物，以及 肝脏靶向活性成分的方法。
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