公开(公告)号：US20240424107A1

公开(公告)日：2024-12-26

申请号：US18628661

申请日：2024-04-05

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

Inventor： Seung Soo OH ,  Hyesung JO

IPC: A61K47/54 ,  A61K47/64 ,  A61K47/68

Abstract: The present invention relates to a preparation of a polypeptide conjugate using an aptamer containing oxanine. In particular, the present invention relates to a composition for preparing a conjugate of a polypeptide, the composition comprising an aptamer containing oxanine, and a method of preparing a conjugate of a polypeptide using the same. The present invention also relates to a conjugate comprising a polypeptide and an aptamer containing oxanine, and a conjugate comprising a polypeptide and a drug.

公开(公告)号：US20230050510A1

公开(公告)日：2023-02-16

申请号：US17792344

申请日：2020-01-30

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

Inventor： Jung Ho JE ,  Seung Soo OH ,  Moon Jung YONG ,  Un YANG

IPC: B81C1/00 ,  A61K9/00

Abstract: Provided is a method of fabricating a core-shell structured nanowire on a tip of an optical fiber, on a substrate, or any position on other target objects, and a nanowire fabricated by the method. The nanowire fabricated by the method of the present invention may be used for a drug delivery system, a sensor, an optical waveguide, and the like.

公开(公告)号：US20220250344A1

公开(公告)日：2022-08-11

申请号：US17306220

申请日：2021-05-03

Applicant: POSTECH Research and Business Development Foundation

Inventor： Jung Ho JE ,  Un YANG ,  Seung Soo OH ,  Moon Jung YONG ,  Byung Hwa KANG

IPC: B29D11/00 ,  G02B6/26

Abstract: Provided is a method of forming a micro/nanowire having a nanometer- to micrometer-sized diameter at predetermined positions of an object. The method includes: preparing a micro/nanopipette having a tip with an inner diameter which is substantially the same as the diameter of the micro/nanowire to be formed; filling the micro/nanopipette with a solution containing a micro/nanowire-forming material; brining the solution into contact with the object through the tip of the micro/nanopipette; and pulling the micro/nanopipette from the object at a pulling speed lower than or equal to a predetermined critical speed (νc) to obtain a micro/nanowire having substantially the same diameter as the inner diameter of the micro/nanopipette tip.

公开(公告)号：US20220242726A1

公开(公告)日：2022-08-04

申请号：US17587922

申请日：2022-01-28

Applicant: POSTECH Research and Business Development Foundation

Inventor： Jung Ho JE ,  Seung Soo OH ,  Un YANG ,  Moon Jung YONG ,  Byung Hwa KANG

IPC: B82B3/00 ,  B82Y40/00 ,  B82Y20/00

Abstract: Provided is a method of fabricating a micro/nanowire having a nanometer- to micrometer-sized diameter at predetermined positions on an object. The method comprises: preparing a micro/nanopipette having a tip with an inner diameter (dpt) which is substantially the same as the diameter of the micro/nanowire to be fabricated; filling the micro/nanopipette with a solution containing a micro/nanowire-forming material; bringing the solution into contact with the object through the tip of the micro/nanopipette; and pulling the micro/nanopipette apart from the object at a pulling speed lower than or equal to a predetermined critical pulling speed (vc) to fabricate a micro/nanowire having substantially the same diameter as the inner diameter of the micro/nanopipette tip (dpt). The critical pulling speed (vc) is defined by a maximum limit of the pulling speed at which the micro/nanowire to be fabricated has the same diameter as the inner diameter of the micro/nanopipette tip (dpt).

公开(公告)号：US20230074735A1

公开(公告)日：2023-03-09

申请号：US17675229

申请日：2022-02-18

Applicant: POSTECH Research and Business Development Foundation

Inventor： Seung Soo OH ,  Hye Bin Yoo

IPC: C12Q1/6823 ,  C12Q1/6853 ,  C12Q1/686

Abstract: The present invention relates to a metal ion-start DNA polymerase switch, a composition for isothermal polymerase amplification containing the same, and an isothermal amplification method using the metal ion-start DNA polymerase switch. The metal ion-start DNA polymerase switch according to the present invention may comprise: a binding module composed of TQ30 aptamer; a locking or unlocking module; and a catalytic module connecting between the binding module and the locking or unlocking module and composed of DNAzyme.

公开(公告)号：US20220244278A1

公开(公告)日：2022-08-04

申请号：US17588571

申请日：2022-01-31

Applicant: POSTECH Research and Business Development Foundation

Inventor： Jung Ho JE ,  Seung Soo OH ,  Moon Jung YONG ,  Un YANG ,  Byung Hwa KANG

IPC: G01N33/84 ,  G01N21/64

Abstract: Provided is a method and apparatus for measuring pH in single cells, and a method of manufacturing a nanoprobe therefor. The apparatus for measuring pH in a single cell comprises: a nanoprobe formed by labeling a pH-responsive fluorescent material to a nanowire grown on a tapered tip of an optical fiber; a manipulator capable of regulating a three-dimensional movement of the nanoprobe to insert the nanoprobe into a single living cell; a light source for applying light to the optical fiber; an optical coupler for connecting the optical fiber with another optical fiber to transmit the light incident through the optical fiber to the nanoprobe and to transmit a fluorescence signal obtained from the nanoprobe through the another optical fiber; and a spectrometer for obtaining a pH value by receiving the fluorescence signal through the another optical fiber and analyzing spectral data from the fluorescence signal.