公开(公告)号：US09632085B2

公开(公告)日：2017-04-25

申请号：US14382043

申请日：2013-02-28

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Michael Super ,  Donald E. Ingber ,  Mark J. Cartwright ,  Alexander Watters ,  John Samuel Workman ,  Daniel Levner ,  Martin Marcus Rottman

IPC: G01N33/53 ,  G01N33/569 ,  C12Q1/18

CPC classification number: G01N33/56938 ,  C12Q1/18 ,  G01N33/56911 ,  G01N33/56916 ,  G01N2333/245 ,  G01N2333/31 ,  G01N2500/10

Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.

公开(公告)号：US20150064703A1

公开(公告)日：2015-03-05

申请号：US14382043

申请日：2013-02-28

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Michael Super ,  Donald E. Ingber ,  Mark J. Cartwright ,  Alexander Watters ,  John Samuel Workman ,  Daniel Levner ,  Martin Rottman

IPC: G01N33/569

CPC classification number: G01N33/56938 ,  C12Q1/18 ,  G01N33/56911 ,  G01N33/56916 ,  G01N2333/245 ,  G01N2333/31 ,  G01N2500/10

Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.

Abstract translation: 本文描述的各个方面的实施方案涉及用于在收集样品后几小时内快速测定微生物的抗生素敏感性的方法，组合物，试剂盒和系统。 在一些实施方案中，本文所述的方法，组合物，试剂盒和系统可以允许基于少量微生物测定微生物的抗生素敏感性，例如与本文所述的微生物靶向底物结合的少至5-10微克。