-
公开(公告)号：US09938221B2
公开(公告)日：2018-04-10
申请号：US14563523
申请日：2014-12-08
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-Francois Bienvenu , Valérie Perron , Brigitte Grouix
IPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04 , C07C57/42
CPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C57/42 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
摘要： The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
-
公开(公告)号：US09439882B2
公开(公告)日：2016-09-13
申请号：US14797957
申请日：2015-07-13
发明人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
IPC分类号： A01N27/00 , A61K31/015 , A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
-
3.发明申请公开(公告)号：US20150018295A1
公开(公告)日：2015-01-15
申请号：US14382080
申请日：2013-02-28
CPC分类号： C07C67/08 , A61K31/225 , A61K31/23 , A61K31/337 , A61K31/513 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/14 , C11C3/02 , C11C3/025 , A61K2300/00
摘要： A method is disclosed for the preparation of glycerol esters (triglycerides) of medium-chain length monocarboxylic fatty acids which consists of the reaction of the precursor free fatty acid and glycerol in the presence of a catalyst under partial vacuum. The process preferably uses a metal catalyst such as an oxide or a chloride of tungsten, molybdenum, calcium, zinc, chromium or magnesium. The method of the invention allows the preparation in high yield and high purity (>99.5%) of the final triglyceride. The present method allows the formation of triglycerides without solvent. Are also contemplated, the triglyceride obtained by the method, and the pharmaceutical composition containing the triglyceride as an excipient or as an active ingredient.
摘要翻译： 公开了用于制备中链长度单羧酸脂肪酸的甘油酯（甘油三酯）的方法，其由部分真空下在催化剂存在下前体游离脂肪酸和甘油的反应组成。 该方法优选使用金属催化剂，例如钨，钼，钙，锌，铬或镁的氧化物或氯化物。 本发明的方法允许以高产率和高纯度（> 99.5％）制备最终甘油三酯。 本方法允许无溶剂形成甘油三酯。 还考虑了通过该方法获得的甘油三酯和含有甘油三酸酯作为赋形剂或作为活性成分的药物组合物。
-
4.发明授权公开(公告)号：US09447016B2
公开(公告)日：2016-09-20
申请号：US14382080
申请日：2013-02-28
IPC分类号： A23D9/00 , C07C67/08 , A61K47/14 , C11C3/02 , A61K31/225 , A61K31/23 , A61K31/337 , A61K31/513 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K45/06
CPC分类号： C07C67/08 , A61K31/225 , A61K31/23 , A61K31/337 , A61K31/513 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/14 , C11C3/02 , C11C3/025 , A61K2300/00
摘要： A method is disclosed for the preparation of glycerol esters (triglycerides) of medium-chain length monocarboxylic fatty acids which consists of the reaction of the precursor free fatty acid and glycerol in the presence of a catalyst under partial vacuum. The process preferably uses a metal catalyst such as an oxide or a chloride of tungsten, molybdenum, calcium, zinc, chromium or magnesium. The method of the invention allows the preparation in high yield and high purity (>99.5%) of the final triglyceride. The present method allows the formation of triglycerides without solvent. Are also contemplated, the triglyceride obtained by the method, and the pharmaceutical composition containing the triglyceride as an excipient or as an active ingredient.
摘要翻译： 公开了用于制备中链长度单羧酸脂肪酸的甘油酯（甘油三酯）的方法，其由部分真空下在催化剂存在下前体游离脂肪酸和甘油的反应组成。 该方法优选使用金属催化剂，例如钨，钼，钙，锌，铬或镁的氧化物或氯化物。 本发明的方法允许以高产率和高纯度（> 99.5％）制备最终甘油三酯。 本方法允许无溶剂形成甘油三酯。 还考虑了通过该方法获得的甘油三酯和含有甘油三酸酯作为赋形剂或作为活性成分的药物组合物。
-
-
-
搜索结果
4 条记录 (耗时 0.016 秒)
