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公开(公告)号：US20170258719A1
公开(公告)日：2017-09-14
申请号：US15299413
申请日：2016-10-20
发明人： Ian MacLachlan , Lloyd Jeffs , Lorne R. Palmer , Cory Giesbrecht
IPC分类号： A61K9/127 , A61K31/7084 , A61K31/7088 , A61K47/10 , A61K47/24 , A61K47/44
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1277 , A61K31/7084 , A61K31/7088 , A61K47/10 , A61K47/24 , A61K47/44
摘要： The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
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公开(公告)号：US20140294937A1
公开(公告)日：2014-10-02
申请号：US14304578
申请日：2014-06-13
发明人： Ian MacLachlan , Lloyd Jeffs , Lorne R. Palmer , Cory Giesbrecht
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1277 , A61K31/7084 , A61K31/7088 , A61K47/10 , A61K47/24 , A61K47/44
摘要： The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
摘要翻译： 本发明提供了用于生产脂质体的装置和方法。 通过在第一储存器中提供缓冲溶液，并将第二储存器中的脂质溶液连续地稀释在混合室中的缓冲溶液中的脂质溶液产生脂质体。 脂溶液优选包含有机溶剂，例如低级链烷醇。
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公开(公告)号：US09492386B2
公开(公告)日：2016-11-15
申请号：US13684066
申请日：2012-11-21
发明人： Ian MacLachlan , Lloyd Jeffs , Lorne R. Palmer , Cory Giesbrecht
IPC分类号： A61K9/127 , A61K47/44 , A61K31/7084 , A61K31/7088 , A61K47/10 , A61K47/24
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1277 , A61K31/7084 , A61K31/7088 , A61K47/10 , A61K47/24 , A61K47/44
摘要： The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
摘要翻译： 本发明提供了用于生产脂质体的装置和方法。 通过在第一储存器中提供缓冲溶液，并将第二储存器中的脂质溶液连续地稀释在混合室中的缓冲溶液中的脂质溶液产生脂质体。 脂溶液优选包含有机溶剂，例如低级链烷醇。
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公开(公告)号：US09504651B2
公开(公告)日：2016-11-29
申请号：US14304578
申请日：2014-06-13
发明人： Ian MacLachlan , Lloyd Jeffs , Lorne R. Palmer , Cory Giesbrecht
IPC分类号： A61K47/10 , A61K47/24 , B01J13/04 , A61K9/127 , A61K47/48 , A61K31/7084 , A61K31/7088 , A61K47/44
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1277 , A61K31/7084 , A61K31/7088 , A61K47/10 , A61K47/24 , A61K47/44
摘要： The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
摘要翻译： 本发明提供了用于生产脂质体的装置和方法。 通过在第一储存器中提供缓冲溶液，并将第二储存器中的脂质溶液连续地稀释在混合室中的缓冲溶液中的脂质溶液产生脂质体。 脂溶液优选包含有机溶剂，例如低级链烷醇。
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公开(公告)号：US09404127B2
公开(公告)日：2016-08-02
申请号：US14642452
申请日：2015-03-09
发明人： Ed Yaworski , Lloyd B. Jeffs , Lorne R. Palmer
IPC分类号： C07H21/04 , C12N15/88 , A61K9/107 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , C12N15/113 , A61K9/127
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/1272 , A61K9/1274 , A61K9/5015 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/543 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
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公开(公告)号：US20160032320A1
公开(公告)日：2016-02-04
申请号：US14642452
申请日：2015-03-09
发明人： Ed Yaworski , Lloyd B. Jeffs , Lorne R. Palmer
IPC分类号： C12N15/88 , A61K31/713 , A61K9/107 , C12N15/113
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/1272 , A61K9/1274 , A61K9/5015 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/543 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
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公开(公告)号：US09926560B2
公开(公告)日：2018-03-27
申请号：US14936169
申请日：2015-11-09
发明人： Ian MacLachlan , Lorne R. Palmer , James Heyes
IPC分类号： C12N15/11 , A61K9/127 , C12N15/88 , C12N15/113 , A61K31/7105 , A61K31/7088
CPC分类号： C12N15/113 , A61K9/1272 , A61K31/7088 , A61K31/7105 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： Rich tooling is provided for REST application development that integrates the exploration of a REST API, modeling of data types and the REST API, and the generation of artifacts using the modeled REST API and data types.
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公开(公告)号：US20140044772A1
公开(公告)日：2014-02-13
申请号：US13684066
申请日：2012-11-21
发明人： Ian MacLachlan , Lioyd Jeffs , Lorne R. Palmer , Cory Giesbrecht
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1277 , A61K31/7084 , A61K31/7088 , A61K47/10 , A61K47/24 , A61K47/44
摘要： The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
摘要翻译： 本发明提供了用于生产脂质体的装置和方法。 通过在第一储存器中提供缓冲溶液，并将第二储存器中的脂质溶液连续地稀释在混合室中的缓冲溶液中的脂质溶液产生脂质体。 脂溶液优选包含有机溶剂，例如低级链烷醇。
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公开(公告)号：US09518272B2
公开(公告)日：2016-12-13
申请号：US15153487
申请日：2016-05-12
发明人： Ed Yaworski , Lloyd B. Jeffs , Lorne R. Palmer
IPC分类号： C07H21/04 , C12N15/88 , A61K9/107 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , C12N15/113 , A61K47/48 , A61K9/127
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/1272 , A61K9/1274 , A61K9/5015 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/543 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
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公开(公告)号：US20160115477A1
公开(公告)日：2016-04-28
申请号：US14936169
申请日：2015-11-09
发明人： Ian MacLachlan , Lorne R. Palmer , James Heyes
IPC分类号： C12N15/113 , A61K31/7088 , A61K9/127
CPC分类号： C12N15/113 , A61K9/1272 , A61K31/7088 , A61K31/7105 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： Rich tooling is provided for REST application development that integrates the exploration of a REST API, modeling of data types and the REST API, and the generation of artifacts using the modeled REST API and data types.
摘要翻译： 为REST应用开发提供了丰富的工具，它集成了REST API的探索，数据类型建模和REST API，以及使用建模的REST API和数据类型生成工件。
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