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公开(公告)号:US20190194690A1
公开(公告)日:2019-06-27
申请号:US16329098
申请日:2017-08-29
发明人: Brian Robert CHAMPION , Alice Claire Noel BROMLEY , Joshua David FREEDMAN , Kerry David FISHER , Leonard William SEYMOUR
CPC分类号: C12N15/86 , A61K35/761 , A61K38/00 , A61K39/39558 , A61K2039/505 , A61K2039/5256 , A61K2039/585 , A61K2300/00 , A61P35/00 , C07K14/521 , C07K16/2809 , C07K16/30 , C07K16/40 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/75 , C07K2319/92 , C12N2710/10332 , C12N2710/10343 , C12N2830/60 , C12N2840/44
摘要: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell engager (BiTE™) comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.
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公开(公告)号:US20180140649A1
公开(公告)日:2018-05-24
申请号:US15570100
申请日:2016-04-29
IPC分类号: A61K35/761 , C07K14/52 , C07K14/56 , C07K14/705 , C07K16/28 , C12N15/86
CPC分类号: A61K35/761 , A61K2039/505 , C07K14/523 , C07K14/56 , C07K14/70532 , C07K16/2809 , C07K2317/56 , C07K2317/622 , C07K2319/03 , C07K2319/74 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2710/10371
摘要: The present disclosure provides a replication competent oncolytic adenovirus with selectivity for cancer cells, wherein the adenovirus comprises a transgene under the control of a promoter endogenous to the virus, wherein the transgene comprises a DNA sequence encoding a B7 protein or an active fragment thereof, compositions comprising same, methods of generating the viruses, and use of the viruses and compositions in treatment, particularly in the treatment of cancer.
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公开(公告)号:US20190233536A1
公开(公告)日:2019-08-01
申请号:US16329125
申请日:2017-08-29
发明人: Brian Robert CHAMPION , Alice Claire Noel BROMLEY , Joshua David FREEDMAN , Kerry David FISHER , Leonard William SEYMOUR
IPC分类号: C07K16/30 , C07K16/40 , C07K16/28 , C12N15/86 , A61K35/761 , A61K39/395 , A61P35/00
CPC分类号: C12N15/86 , A61K35/761 , A61K38/00 , A61K39/39558 , A61K2039/505 , A61K2039/5256 , A61K2039/585 , A61K2300/00 , A61P35/00 , C07K14/521 , C07K16/2809 , C07K16/30 , C07K16/40 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/75 , C07K2319/92 , C12N2710/10332 , C12N2710/10343 , C12N2830/60 , C12N2840/44
摘要: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with at least two bispecific T cell engager (BiTE™) each comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on an immune cell of interest, such as a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.
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公开(公告)号:US20180042973A1
公开(公告)日:2018-02-15
申请号:US15799644
申请日:2017-10-31
IPC分类号: A61K35/761 , C07K14/705 , C12N7/00
CPC分类号: A61K35/761 , A61K2039/505 , C07K14/523 , C07K14/56 , C07K14/70532 , C07K16/2809 , C07K2317/56 , C07K2317/622 , C07K2319/03 , C07K2319/74 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2710/10371
摘要: The present disclosure provides a replication competent oncolytic adenovirus with selectivity for cancer cells, wherein the adenovirus comprises a transgene under the control of a promoter endogenous to the virus, wherein the transgene comprises a DNA sequence encoding a B7 protein or an active fragment thereof, compositions comprising same, methods of generating the viruses, and use of the viruses and compositions in treatment, particularly in the treatment of cancer.
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