公开(公告)号：US20150320909A1

公开(公告)日：2015-11-12

申请号：US14442387

申请日：2013-11-12

申请人： PUGET SOUND BLOOD CENTER

发明人： Dominic Chung ,  Jose Aron Lopez ,  Minhua Ling ,  Junmei Chen ,  Xiaoyun Fu

IPC分类号： A61L29/14 ,  A61L29/08 ,  C07K14/775 ,  A61L31/14 ,  A61L31/16 ,  A61L31/10 ,  C07K14/755 ,  A61L29/04

CPC分类号： A61K9/0019 ,  A61K38/00 ,  A61K47/42 ,  A61L29/048 ,  A61L29/085 ,  A61L29/143 ,  A61L29/16 ,  A61L31/10 ,  A61L31/143 ,  A61L31/16 ,  A61L2300/424 ,  A61L2400/18 ,  C07K14/755 ,  C07K14/775 ,  Y02A50/411

摘要： Compositions and methods are described for preventing or reducing protein loss due to protein aggregation, denaturation, and absorption to surfaces. Also described are compositions and methods for preventing or reducing the fouling or clogging of medical devices that come into contact with blood, such as catheters. Also described are methods to treat diseases caused by activation of the microvasculature.

摘要翻译： 描述了用于预防或减少由于蛋白质聚集，变性和对表面吸收引起的蛋白质损失的组合物和方法。 还描述了用于防止或减少与血液接触的医疗装置（例如导管）的结垢或堵塞的组合物和方法。 还描述了治疗由微血管活化引起的疾病的方法。