公开(公告)号：US20240238234A1

公开(公告)日：2024-07-18

申请号：US18480145

申请日：2023-10-03

Applicant: PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

Inventor： Jong-Min LEE ,  Won-Je Jang ,  Dong-Nyoung Oh

IPC: A61K31/198 ,  A61P1/14 ,  A61P3/04 ,  A61P3/08

CPC classification number: A61K31/198 ,  A61P1/14 ,  A61P3/04 ,  A61P3/08

Abstract: An object of the present disclosure is to provide a composition for preventing or treating obesity comprising a substance isolated from poly-γ-glutamic acid (γ-PGA) as an active ingredient. According to the present disclosure, it was confirmed that γ-PGAbm or γ-PGAcm, a substance isolated from γ-PGA, suppressed the expression of adipogenic marker genes in 3T3-L1 cells to reduce accumulation of lipid droplets and triglycerides, and suppressed the expression of cell cycle regulators in the early stage of adipogenesis to reduce adipocyte differentiation. In addition, γ-PGAbm or γ-PGAcm has been confirmed to suppress obesity through weight loss, positive changes in glucose and insulin resistance, reduction of epididymal adipocytes, and suppression of adipogenesis, and thus may be used effectively for related businesses.