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公开(公告)号：US20240325418A1
公开(公告)日：2024-10-03
申请号：US18703647
申请日：2022-10-21
CPC分类号： A61K31/69 , A23F5/02 , A61K36/742 , A61K45/06 , A61P1/12 , A61P1/14 , G01N33/50 , A61K2236/333
摘要： A borate diester of chlorogenic acid is prepared by reacting a solution comprising chlorogenic acid and boric acid in a ratio of at least 2:1 in a superheated water solvent or an aqueous acetonitrile solvent. If aqueous acetonitrile is used as a solvent, the acetonitrile solvent is evaporated to leave a water solution. A product containing the desired borate diester is obtained by freeze-drying or air-drying the water solution. Insufficient levels of boron in a microbiome in a subject in need thereof may be treated by administering the borate diester of chlorogenic acid to the subject.
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公开(公告)号：US12090180B2
公开(公告)日：2024-09-17
申请号：US17496919
申请日：2021-10-08
发明人： Sridhar Mani , Libusha Kelly , Hao Li
IPC分类号： A61K35/744 , A61K9/00 , A61K9/48 , A61K35/741 , A61K35/742 , A61P1/14 , C12N1/20 , G01N33/483
CPC分类号： A61K35/744 , A61K9/48 , A61K35/741 , A61K35/742 , C12N1/20 , G01N33/483 , A61K9/0031 , A61K9/0053 , A61P1/14 , Y02A50/30
摘要： Bacterial hyperswarmers are disclosed for treatment, prevention and diagnosis of conditions such as intestinal inflammation.
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公开(公告)号：US20240300943A1
公开(公告)日：2024-09-12
申请号：US18282182
申请日：2022-03-16
发明人： Juhyun Lee , Young Ju Kim , Jun Kim , Hanna Kim , Jong Ryoul Choi , Jae Hong Kweon , Dongkyu Kim , Yeji Byeon , Hyunwoo Shin , Daseul Yoon , Ye-Lim Lee , Seung Hee Jung , Do Seok Hwang
IPC分类号： C07D471/04 , A61K31/444 , A61P1/14 , A61P17/02 , C07C55/07 , C07C309/04 , C07C309/25 , C07C309/35
CPC分类号： C07D471/04 , A61K31/444 , A61P1/14 , A61P17/02 , C07C55/07 , C07C309/04 , C07C309/25 , C07C309/35 , C07C2602/48
摘要： The present invention relates to novel salts of a heterocyclic compound as a protein kinase inhibitor and uses thereof. The novel salts are superb in terms of water solubility and physical and chemical stability and thus can be usefully employed in formulating medicinal products. In addition, the heterocyclic compound or the salts thereof can effectively treat and prevent atopic dermatitis and inflammatory bowel disease.
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公开(公告)号：US12076356B2
公开(公告)日：2024-09-03
申请号：US17282820
申请日：2019-09-19
发明人： Ho-Young Park , Yoon-sook Kim , Young-do Nam , Moon Ho Do , Mi-Jin Oh , Sang-hoon Lee , Eun Jung Lee , Hye-Bin Lee , Hyun Jhung Jhun
IPC分类号： A61K36/185 , A61P1/00 , A61P1/14 , A61P3/04 , A61P29/00
CPC分类号： A61K36/185 , A61P1/00 , A61P1/14 , A61P3/04 , A61P29/00
摘要： The present invention relates to a prebiotic composition, a composition for improving gut microorganisms, a composition for improving gut health or gut function, a composition for alleviating, preventing, or treating inflammatory bowel disease or leaky gut syndrome, or a composition for alleviating, preventing, or treating obesity or metabolic disease, which each comprise a molokhia extract or a molokhia polymer fraction as an active ingredient to induce the proliferation of beneficial intestinal bacteria and to improve, prevent, or treat gut heath or gut function. In addition, the composition comprising a molokhia extract or a molokhia polymer fraction as an active ingredient can alleviate, prevent, or treat bowel disease or leaky gut syndrome. Moreover, the composition of the present invention comprises a molokhia extract or a molokhia polymer fraction as an active ingredient that improves immunological activity as well as having anti-obesity activity, thereby not only treating obesity, but also alleviating, preventing, or treating obesity-induced metabolic diseases and as such, is very advantageous.
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公开(公告)号：US20240252449A1
公开(公告)日：2024-08-01
申请号：US18431461
申请日：2024-02-02
申请人： Rumin8 Pty Ltd
CPC分类号： A61K31/02 , A61K9/0056 , A61K9/107 , A61K9/1075 , A61K9/127 , A61P1/14
摘要： Compositions for reducing or inhibiting methanogenesis in ruminants comprising, at least one halocarbon compound and one or more stabilising agents.
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公开(公告)号：US20240238353A1
公开(公告)日：2024-07-18
申请号：US18286133
申请日：2022-04-06
发明人： Racheli TAMIR , Alon KARPOL , Aharon EYAL , Bryan P. TRACY
IPC分类号： A61K35/742 , A61K9/00 , A61K9/20 , A61K45/06 , A61P1/14
CPC分类号： A61K35/742 , A61K9/0053 , A61K9/20 , A61K45/06 , A61P1/14
摘要： Provided are methods, compositions, food and beverages, food and beverage additives and kits comprising probiotic microorganisms and uses thereof for treating or preventing a condition caused by eating a cruciferous vegetable or legume in a subject in need thereof. Further provided are compositions comprising an effective dose of an organism within the order Clostridiales and a carrier, wherein said microorganism is present at a concentration of from about 1 to about 10% wt of the total composition.
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公开(公告)号：US20240041829A1
公开(公告)日：2024-02-08
申请号：US18258560
申请日：2021-12-23
发明人： Raz JELINEK , Orit MALKA , Omry KOREN
IPC分类号： A61K31/404 , A61K35/741 , A61K35/747 , A61K35/20 , A61P29/00 , A61K36/062 , A61K31/05 , A61K35/744 , A61P1/14 , A61K35/00
CPC分类号： A61K31/404 , A61K35/741 , A61K35/747 , A61K35/20 , A61P29/00 , A61K36/062 , A61K31/05 , A61K35/744 , A61P1/14 , A61K2035/115
摘要： The present invention is directed to compositions comprising a Tryptophol derivative, a 4-Ethyl-Phenol derivative, or a combination thereof, and methods of using same, such as for modulating abundance, diversity, or both, of a microbial population tin a subject in need thereof.
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公开(公告)号：US20240041821A1
公开(公告)日：2024-02-08
申请号：US18258455
申请日：2021-10-01
IPC分类号： A61K31/352 , A61K9/127 , A61P29/00 , A61P1/14
CPC分类号： A61K31/352 , A61K9/127 , A61P29/00 , A61P1/14
摘要： The present invention relates to an active ingredient and a drug or composition, respectively, for use in reducing pathogenic germs in the human intestine or for use in reducing colonization of the human intestine with pathogenic germs, preferentially for the purpose of preventing, reducing or curing inflammatory diseases or preferentially for the purpose of prophylactic or therapeutic treatment of inflammatory diseases of the human body.
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公开(公告)号：US20230363412A1
公开(公告)日：2023-11-16
申请号：US17432725
申请日：2020-02-20
申请人： Elanco US Inc.
IPC分类号： A23K10/18 , A61K35/742 , A61K9/00 , A23K50/75 , A61P1/14
CPC分类号： A23K10/18 , A61K35/742 , A61K9/0056 , A23K50/75 , A61P1/14
摘要： The present disclosure relates to methods, compositions, and uses of a bacillus strain for providing a benefit in terms of body weight, adjusted feed conversion, and/or average daily weight gain in poultry. In particular, the present disclosure provides a method of providing Bacillus strain 747
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公开(公告)号：US20230241152A1
公开(公告)日：2023-08-03
申请号：US18000146
申请日：2021-05-29
申请人： LAILA NUTRACEUTICALS
发明人： Ganga Raju GOKARAJU , Rama Raju Gokaraju , Kiran BHUPATHIRAJU , Venkata Kanaka Ranga Raju GOKARAJU , Trimurtulu GOLAKOTI , Krishanu SENGUPTHA , Venkateswarlu SOMEPALLI , Venkata Krishna Raju ALLURI
IPC分类号： A61K36/888 , A23L33/00 , A23L33/105 , A61K36/185 , A61K36/81 , A61P1/14
CPC分类号： A61K36/888 , A23L33/40 , A23L33/105 , A61K36/185 , A61K36/81 , A61P1/14 , A61K2236/331 , A61K2236/333
摘要： Synergistic Herbal Compositions For Improving Gut Health” The present invention discloses synergistic herbal compositions comprising at least two ingredients selected from extract(s), fraction(s), phytochemical(s), or mixtures thereof derived each one from a different herb selected from Abelmoschus esculentus, Withania somnifera and Amorphophallus paeoniifolius; improving at least one gut health function selected from gut-brain axis, easing of constipation, bowel movement, improved GI motility, digestion and gut immunity; and reducing gut inflammation. The invention further relates to methods of treatment and the use of the compositions.
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