公开(公告)号：US11891391B2

公开(公告)日：2024-02-06

申请号：US17243629

申请日：2021-04-29

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clement Opoku-Temeng

IPC: C07D471/06 ,  A61K31/437 ,  C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07B2200/05

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US11731964B2

公开(公告)日：2023-08-22

申请号：US17046957

申请日：2019-03-29

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Mohamed Seleem ,  Clement Opoku-Temeng ,  Haroon Taj Mohammad ,  George Naclerio

IPC: C07D417/14 ,  A61P31/04 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D417/14 ,  A61P31/04 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Clostridioides difficile. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US20210371420A1

公开(公告)日：2021-12-02

申请号：US17243629

申请日：2021-04-29

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clement Opoku-Temeng

IPC: C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US11040973B2

公开(公告)日：2021-06-22

申请号：US16499133

申请日：2018-03-29

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clement Opoku-Temeng

IPC: C07D471/02 ,  A61K31/4745 ,  C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US20200308173A1

公开(公告)日：2020-10-01

申请号：US16499133

申请日：2018-03-29

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clement Opoku-Temeng

IPC: C07D471/14 ,  C07D491/147 ,  C07D471/04 ,  C07D495/14 ,  C07D417/12 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D519/00 ,  C07D513/04 ,  C07D498/04

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.