公开(公告)号：US20240208971A1

公开(公告)日：2024-06-27

申请号：US18392204

申请日：2023-12-21

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clemen Opoku-Temeng

IPC: C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07B2200/05

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US11891391B2

公开(公告)日：2024-02-06

申请号：US17243629

申请日：2021-04-29

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clement Opoku-Temeng

IPC: C07D471/06 ,  A61K31/437 ,  C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07B2200/05

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US20230312562A1

公开(公告)日：2023-10-05

申请号：US18012564

申请日：2021-07-01

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Neetu Dayal

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The present invention generally relates to tetrahydro-3H-pyrazolo-[4,3-f]-quinolone and tetrahydro-3H-pyrrolo-[3,2-f]quinoline-containing compounds as a tubulin polymerization inhibitor for the treatment of various cancers, and methods of uses thereof. Pharmaceutical compositions and the methods for treating those kinase related diseases are within the scope of this invention.

公开(公告)号：US20230219934A1

公开(公告)日：2023-07-13

申请号：US18009311

申请日：2021-06-24

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Elizabeth Anne Larocque ,  Delmis E. Hernandez ,  Neetu Dayal

IPC: C07D403/14 ,  A61P35/00

CPC classification number: C07D403/14 ,  A61P35/00

Abstract: The present invention generally relates to 2,3-Disubstituted pyrido[3,4-b]pyrazine-containing compounds as a kinase inhibitor and methods of uses thereof. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.

公开(公告)号：US20210371420A1

公开(公告)日：2021-12-02

申请号：US17243629

申请日：2021-04-29

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clement Opoku-Temeng

IPC: C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US11040973B2

公开(公告)日：2021-06-22

申请号：US16499133

申请日：2018-03-29

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clement Opoku-Temeng

IPC: C07D471/02 ,  A61K31/4745 ,  C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US20200308173A1

公开(公告)日：2020-10-01

申请号：US16499133

申请日：2018-03-29

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clement Opoku-Temeng

IPC: C07D471/14 ,  C07D491/147 ,  C07D471/04 ,  C07D495/14 ,  C07D417/12 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D519/00 ,  C07D513/04 ,  C07D498/04

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.