公开(公告)号：US11802315B2

公开(公告)日：2023-10-31

申请号：US16633389

申请日：2018-08-09

申请人： PamGene B.V. ,  Erasmus University Medical Center Rotterdam

发明人： Robby Ruijtenbeek ,  Dirgje Maria Adriana Van Den Heuvel ,  Richard De Wijn ,  Joan Gertrudis Jacobus Victor Aerts ,  Adrianus Henricus Josephus Mathijssen

IPC分类号： C12Q1/6886 ,  C12Q1/48

CPC分类号： C12Q1/6886 ,  C12Q1/485 ,  G01N2440/14 ,  G01N2800/52 ,  G01N2800/7028

摘要： The present invention relates to a method for determining or predicting the response of a patient diagnosed with non-small-cell lung carcinoma to targeted pharmacotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with non-small-cell lung carcinoma to specific medicaments. More specifically, the present invention provides methods which measure kinase-activity by studying phosphorylation levels and profiles and inhibitions thereof by drugs in blood samples of said patients.