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    Process for preparation of penam derivatives from cepham derivatives
    3.
    发明授权
    Process for preparation of penam derivatives from cepham derivatives 失效
    头孢烯衍生物的制备方法

    公开(公告)号：US06936711B2

    公开(公告)日：2005-08-30

    申请号：US10309201

    申请日：2002-12-04

    申请人： Pandurang Balwant Deshpande ,  Senthil Kumar Udayampalayam Palanisamy ,  Gnanaprakasam Andrew

    发明人： Pandurang Balwant Deshpande ,  Senthil Kumar Udayampalayam Palanisamy ,  Gnanaprakasam Andrew

    IPC分类号： C07D499/06 ,  C07B61/00 ,  C07D499/00 ,  C07D499/44 ,  C07D499/87

    CPC分类号： C07D499/00 ,  Y02P20/55

    摘要： The present invention relates to a process for preparing 2α-methyl-2β-substituted methyl penam derivatives from cepham derivatives, more particularly the present invention provides a novel process for preparing 2β-heterocyclyl methyl penam derivatives of the formula (I) by reacting a cepham compound with a heterocylic amine to form an intermediate compound, and oxidizing the intermediate compound to produce the 2β-heterocyclyl methyl penam derivatives of the formula (I), wherein R1 represents carboxylic acid protecting group; R2 and R3 may be same or different and independently represent hydrogen, halogen, NH2, acylamino, phthalimido with a proviso that both R2 and R3 are not NH2, acylamino, phthalimido; Het represents a 5 or 6 membered nitrogen containing heterocycle ring system having one or more heteroatoms selected from O, S, or N.

    摘要翻译： 本发明涉及一种从头孢烯衍生物制备2α-甲基-2β-取代的甲基对苯二甲酸衍生物的方法，更具体地说本发明提供了一种制备式（I）的2ba- 与杂环胺的化合物形成中间体化合物，并氧化中间体化合物以制备式（I）的其中R 1代表羧酸保护基团的2b-杂环基甲基对苯二甲酸衍生物; R 2和R 3可以相同或不同，并且独立地表示氢，卤素，NH 2，酰氨基，苯二甲酰亚氨基，条件是R R 2和R 3不是NH 2，酰氨基，邻苯二甲酰亚氨基; Het表示具有一个或多个选自O，S或N的杂原子的5或6元含氮杂环体系。

    Method for the conversion of a Z-isomer into E-isomer
    4.
    发明授权
    Method for the conversion of a Z-isomer into E-isomer 失效
    将Z-异构体转化为E-异构体的方法

    公开(公告)号：US06844471B2

    公开(公告)日：2005-01-18

    申请号：US10310048

    申请日：2002-12-05

    申请人： Pandurang Balwant Deshpande ,  Senthil Kumar Udayampalayam Palanisamy ,  Gnanaprakasam Andrew

    发明人： Pandurang Balwant Deshpande ,  Senthil Kumar Udayampalayam Palanisamy ,  Gnanaprakasam Andrew

    IPC分类号： C07C37/055 ,  C07C39/21 ,  C07C41/32 ,  C07C43/215 ,  C07C39/12

    CPC分类号： C07C37/055 ,  C07B2200/09 ,  C07C41/32 ,  C07C43/215 ,  C07C39/21

    摘要： A method of converting (Z)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (II) to (E)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (I) wherein R1, R2, and R3 are the same or different and independently represent (C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkoxy(C1-C4)alkyl, allyl, vinyl, silyl, formyl, acyl, aryl(C1-C4)alkyl or substituted aryl(C1-C4)alkyl group. The present invention also provides a process for the conversion of (E)-(3,5-disubstituted phenyl-2-(4-substituted phenyl)ethene of general formula (I) to E-resveratrol of formula (III).

    摘要翻译： 将通式（II）的（Z）-1-（3,5-二取代苯基）-2-（4-取代苯基）乙烯转化成（E）-1-（3,5-二取代苯基） - 通式（I）的2-（4-取代苯基）乙烯，其中R 1，R 2和R 3相同或不同并且独立地表示（C 1 -C 4）烷基，（C 1 -C 4）烷氧基（C 1 -C 4）烷基， （C1-C4）烷氧基（C1-C4）烷氧基（C1-C4）烷基，烯丙基，乙烯基，甲硅烷基，甲酰基，酰基，芳基（C1-C4）烷基或取代芳基（C1-C4）烷基。 本发明还提供了将通式（I）的（E） - （3,5-二取代苯基-2-（4-取代苯基）乙烯转化为式（III）的白藜芦醇的方法。