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公开(公告)号：US11773109B2
公开(公告)日：2023-10-03
申请号：US16925043
申请日：2020-07-09
申请人： The Catholic University of Korea Industry—Academic Cooperation Foundation , Korea Research Institute of Chemical Technology
发明人： Sang Chul Lee , Say June Kim , Kwan Young Jeong , Ok Hee Kim , Seok Jun Jo , Min Jin Yoo
IPC分类号： C07D499/21 , C07D499/06 , G01N33/483 , G01N33/50 , C07D215/20
CPC分类号： C07D499/21 , C07D499/06 , G01N33/4833 , G01N33/50 , C07D215/20
摘要： The present invention relates to various compounds capable of temporarily hardening soft tissue for surgical suturing of the soft tissue. The compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, thereby improving the suturing efficiency during suturing of the soft tissue, thereby preventing aftereffects or the like from occurring due to insufficient anastomosis. In addition, the compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, particularly pancreas, thereby increasing the suturing efficiency during pancreaticoduodenectomy and effectively preventing pancreatic leakage.
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公开(公告)号：US20190315770A1
公开(公告)日：2019-10-17
申请号：US16325073
申请日：2017-08-11
申请人： THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
发明人： Sang Chul LEE , Say June KIM , Kwan Young JEONG , Ok Hee KIM , Seok Jun JO , Min Jin YOO
IPC分类号： C07D499/21 , G01N33/483 , G01N33/50 , C07D499/06
摘要： The present invention relates to various compounds capable of temporarily hardening soft tissue for surgical suturing of the soft tissue. The compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, thereby improving the suturing efficiency during suturing of the soft tissue, thereby preventing aftereffects or the like from occurring due to insufficient anastomosis. In addition, the compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, particularly pancreas, thereby increasing the suturing efficiency during pancreaticoduodenectomy and effectively preventing pancreatic leakage.
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公开(公告)号：US4849516A
公开(公告)日：1989-07-18
申请号：US109263
申请日：1987-10-14
IPC分类号： C07D507/04 , C07D205/08 , C07D273/04 , C07D413/06 , C07D477/00 , C07D498/04 , C07D499/06 , C07D499/88 , C07D499/897 , C07D507/06 , C07D507/08
CPC分类号： C07D413/06 , C07D205/08 , C07D273/04
摘要： Compounds of the formula (V): ##STR1## wherein R.sup.1 is certain optionally substituted alkyl groups, R.sup.2 is hydrogen, alkyl or optionally substituted phenyl and R.sup.3 and R.sup.4 are independently alkyl or optionally substituted phenyl, or together form a C.sub.4-7 cycloalkyl ring; are described as useful intermediates in the preparation of carbapenem and penem antibiotics. Processes for their preparation are described as are certain oxadiazine intermediates.
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公开(公告)号：US4584133A
公开(公告)日：1986-04-22
申请号：US549535
申请日：1983-11-07
IPC分类号： C07D499/897 , A61K31/425 , A61K31/43 , A61P31/04 , C07D205/09 , C07D499/00 , C07D499/06 , C07D499/88 , C07D499/893 , C07F7/08 , C07F7/18 , C07D205/08 , C07D487/04
CPC分类号： C07D205/09 , C07D499/88 , C07F7/0818 , C07F7/186 , Y02P20/55
摘要： Improved processes for the production of 6-hydroxyethyl-2-substituted thio penem-3-carboxylates which eliminate the step of using a silver reagent are disclosed.
摘要翻译： 公开了用于生产6-羟乙基-2-取代的硫代青霉烯-3-羧酸盐的改进方法，其消除了使用银试剂的步骤。
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公开(公告)号：US4577016A
公开(公告)日：1986-03-18
申请号：US481924
申请日：1983-04-04
IPC分类号： C07D499/897 , A61K31/43 , A61K31/431 , A61P31/04 , C07D499/04 , C07D499/06 , C07D499/88 , C07D499/883 , C07D519/00 , C07F7/18 , C07D499/00 , A61K31/425
CPC分类号： C07F7/186 , C07D499/88 , C07F7/1804 , Y02P20/55
摘要： A process for the preparation of compounds of formula (I) ##STR1## wherein R.sub.1 is hydrogen or an organic group;R.sub.2 is hydrogen or a carboxy protecting group; andY is a group-S-heterocyclic, acyloxy, alkoxy, alkylthio, pyridyl, which group may be substituted, or azido, and penem derivatives falling within the scope of formula (I) and pharmaceutically or veterinarily acceptable salts thereof.The process involves displacing a group L in the Y position with a reagent Y-H.
摘要翻译： 制备式（I）化合物的方法其中R 1是氢或有机基团; R2是氢或羧基保护基; Y是可以被取代的基团-S-杂环，酰氧基，烷氧基，烷硫基，吡啶基，或叠氮基和落在式（I）的范围内的青霉烯衍生物及其药学上或兽医学上可接受的盐。 该方法包括用试剂Y-H置换Y位置的基团L.
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公开(公告)号：US4331676A
公开(公告)日：1982-05-25
申请号：US902639
申请日：1978-05-04
申请人： Jacques Gosteli , Ivan Ernest , Robert B. Woodward
发明人： Jacques Gosteli , Ivan Ernest , Robert B. Woodward
IPC分类号： C07D499/897 , C07D205/08 , C07D205/09 , C07D499/04 , C07D499/06 , C07D499/86 , C07D499/87 , C07D499/88 , C07F9/568 , C07D499/00
CPC分类号： C07F9/5683 , C07D205/09 , C07D499/88
摘要： 2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group andR.sub.2 represents hydroxy or a radical R.sub.2.sup.A forming together with the carbonyl grouping --C(.dbd.O)-- a protected carboxyl group, 1-oxides thereof, as well as salts of such compounds having salt-forming groups, in racemic and optically active form, processes for their preparation, pharmaceutical compositions containing such compounds, and their use as antibiotics, and intermediates and their processes which are useful in the production of the compounds of the formula I.
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公开(公告)号：US4260618A
公开(公告)日：1981-04-07
申请号：US948711
申请日：1978-10-10
IPC分类号： C07D499/897 , A61K31/43 , A61P31/04 , C07D205/08 , C07D205/085 , C07D205/09 , C07D205/095 , C07D499/00 , C07D499/06 , C07D499/44 , C07D499/46 , C07D499/86 , C07D499/861 , C07D499/87 , C07D499/88 , C07F9/568
CPC分类号： C07F9/5683 , C07D205/08 , C07D205/085 , C07D205/09 , C07D205/095 , C07D499/00 , C07D499/88
摘要： Disclosed are 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein R is, inter alia, hydrogen, --OR, --SR, --NR.sub.2, alkyl, aryl, aralkyl, or heterocylcyl; n is 0 or 1; when n=1 R is as defined but not --SR. Such compounds and their pharmaceutically acceptable salt and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
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公开(公告)号：US4215124A
公开(公告)日：1980-07-29
申请号：US948712
申请日：1978-10-10
IPC分类号： C07D499/897 , A61K31/43 , A61P31/04 , C07D205/08 , C07D205/085 , C07D205/09 , C07D205/095 , C07D499/00 , C07D499/06 , C07D499/44 , C07D499/46 , C07D499/86 , C07D499/861 , C07D499/87 , C07D499/88 , C07F9/568 , C07D277/02
CPC分类号： C07F9/5683 , C07D205/08 , C07D205/085 , C07D205/09 , C07D205/095 , C07D499/00 , C07D499/88
摘要： Disclosed are 6-substituted amino-2-substituted-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein R.sup.1 is hydrogen or acyl, R.sup.2 is hydrogen or methoxyl, and R.sup.3 is inter alia, hydrogen, --R, --OR, --SR, --NR.sub.2, R is alkyl, aryl, aralkyl, heterocyclyl or heterocyclylalkyl; n is 0 or 1; when n=1, R.sup.3 is not --SR.Such compounds and their pharmaceutically acceptable salt, and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
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公开(公告)号：US20200339601A1
公开(公告)日：2020-10-29
申请号：US16925043
申请日：2020-07-09
申请人： The Catholic University of Korea Industry-Academic Cooperation Foundation , Korea Research Institute of Chemical Technology
发明人： Sang Chul Lee , Say June Kim , Kwan Young Jeong , Ok Hee Kim , Seok Jun Jo , Min Jin Yoo
IPC分类号： C07D499/21 , C07D499/06 , G01N33/483 , G01N33/50
摘要： The present invention relates to various compounds capable of temporarily hardening soft tissue for surgical suturing of the soft tissue. The compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, thereby improving the suturing efficiency during suturing of the soft tissue, thereby preventing aftereffects or the like from occurring due to insufficient anastomosis. In addition, the compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, particularly pancreas, thereby increasing the suturing efficiency during pancreaticoduodenectomy and effectively preventing pancreatic leakage.
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公开(公告)号：US10745417B2
公开(公告)日：2020-08-18
申请号：US16325073
申请日：2017-08-11
申请人： THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
发明人： Sang Chul Lee , Say June Kim , Kwan Young Jeong , Ok Hee Kim , Seok Jun Jo , Min Jin Yoo
IPC分类号： C07D499/06 , C07D499/21 , G01N33/483 , G01N33/50 , C07D215/20
摘要： The present invention relates to various compounds capable of temporarily hardening soft tissue for surgical suturing of the soft tissue. The compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, thereby improving the suturing efficiency during suturing of the soft tissue, thereby preventing aftereffects or the like from occurring due to insufficient anastomosis. In addition, the compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, particularly pancreas, thereby increasing the suturing efficiency during pancreaticoduodenectomy and effectively preventing pancreatic leakage.
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