公开(公告)号：US5549913A

公开(公告)日：1996-08-27

申请号：US153437

申请日：1993-11-16

申请人： Paolo Colombo ,  Antonio C. Cardona ,  Giorgio Pifferi

发明人： Paolo Colombo ,  Antonio C. Cardona ,  Giorgio Pifferi

IPC分类号： A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/48 ,  A61K47/04 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42

CPC分类号： A61K9/2086 ,  A61K9/209

摘要： This invention concerns systems for the release of active principles which are capable of releasing active principle(s) into an aqueous medium at a controlled rate.More precisely, the invention concerns a monolithic system for the controlled release of active principles, consisting of:a) at least one swelling layer containing one or more active principles, in a matrix of swellable, hydrophilic polymers;b) at least one erodible and/or soluble layer comprising excipients and/or water soluble polymers, possibly containing one or more active principles, either the same or different from those present in the layer a), the said erodible and/or soluble layer being in contact with the swelling layer(s) a).

摘要翻译： 本发明涉及释放能够以受控速率将有效原理释放到水性介质中的活性原理的系统。 更准确地说，本发明涉及用于控制释放活性成分的整体系统，其包括：a）在可溶胀亲水性聚合物基质中含有一种或多种活性成分的至少一种溶胀层; b）至少一个包含赋形剂和/或水溶性聚合物的可侵蚀和/或可溶性层，其可能含有一个或多个与层a）中存在的活性成分相同或不同的活性成分，所述可侵蚀和/或可溶层 与膨胀层a）接触。