公开(公告)号：US07364754B2

公开(公告)日：2008-04-29

申请号：US10764677

申请日：2004-01-26

申请人： Paras Prasad ,  Indrajit Roy ,  Earl J. Bergey ,  Tymish Y. Ohulchansky ,  Haridas Pudavar

发明人： Paras Prasad ,  Indrajit Roy ,  Earl J. Bergey ,  Tymish Y. Ohulchansky ,  Haridas Pudavar

IPC分类号： A61K9/14 ,  A61K31/57

CPC分类号： A61K9/5115 ,  A61K31/555 ,  A61K41/0057 ,  A61K41/0071 ,  B82Y5/00

摘要： The present invention provides methods and compositions for photodynamic therapy. The composition comprises ceramic nanoparticles in which a photosensitive drug/dye is entrapped. The ceramic nanoparticles are made by formation of a micellar composition of the dye. The ceramic material is added to the micellar composition and the ceramic nanoparticles are precipitated by alkaline hydrolysis. The precipitated nanoparticles in which the photosensitive dye/drug is entrapped can be isolated by dialysis. The resulting drug doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. Irradiation with light of suitable wavelength of the photosensitizing drug entrapped inside nanoparticles resulted in generation of singlet oxygen, which was able to diffuse out through the pores of the ceramic matrix. The drug loaded ceramic nanoparticles of the present invention can be used as drug carriers for photodynamic therapy.

摘要翻译： 本发明提供光动力疗法的方法和组合物。 该组合物包含其中包含光敏药物/染料的陶瓷纳米颗粒。 通过形成染料的胶束组合物制备陶瓷纳米颗粒。 将陶瓷材料加入到胶束组合物中，并通过碱水解沉淀陶瓷纳米颗粒。 可以通过透析分离感光性染料/药物被捕获的沉淀的纳米粒子。 所得药物掺杂的纳米颗粒是球形的，高度单分散的，并且在水性体系中稳定。 用纳米颗粒内的光敏药物的合适波长的光照射导致产生单线态氧，其能够通过陶瓷基质的孔扩散出来。 本发明的载药陶瓷纳米颗粒可用作光动力疗法的药物载体。

公开(公告)号：US20070134340A1

公开(公告)日：2007-06-14

申请号：US11471075

申请日：2006-06-20

申请人： Paras Prasad ,  Haridas Pudavar ,  Koichi Baba ,  Indrajit Roy ,  Tymish Ohulchanskyy ,  Ravindra Pandey ,  Allan Oseroff

发明人： Paras Prasad ,  Haridas Pudavar ,  Koichi Baba ,  Indrajit Roy ,  Tymish Ohulchanskyy ,  Ravindra Pandey ,  Allan Oseroff

IPC分类号： A61K31/555 ,  A61K31/409 ,  A61K9/14

CPC分类号： A61K9/14 ,  A61K9/146 ,  A61K31/409 ,  A61K31/4745 ,  A61K31/555 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0067 ,  G01N33/5005 ,  G01N33/52

摘要： This invention provides nanocrystals or polymer doped nanocrystals of hydrophobic drug molecules as stably dispersed in an aqueous system which are prepared without stabilizers like surfactants and the like. In one embodiment, the drug is a tetra-pyrrole compound. An example is the hydrophobic photosensitizing anticancer drug 2-devinyl-2-(1-hexyloxyethyl)pyropheophorbide (HPPH). Pharmaceutical compositions comprising nanocrystals or polymer doped nanocrystals of hydrophobic drugs can be used for therapeutic purposes. For example pyropheophorbides such as HPPH can be used for photodynamic therapy. Drug efficacy of these nanocrystals were found to be comparable with that of same drug formulated in conventional delivery vehicles under in vitro and in vivo conditions.

摘要翻译： 本发明提供了稳定分散在水性体系中的疏水药物分子的纳米晶体或聚合物掺杂的纳米晶体，其不经过稳定剂如表面活性剂等制备。 在一个实施方案中，药物是四吡咯化合物。 一个例子是疏水性光敏抗癌药2-脱乙烯基-2-（1-己氧基乙基）焦脱镁叶绿素（HPPH）。 包含纳米晶体或疏水性药物的聚合物掺杂纳米晶体的药物组合物可用于治疗目的。 例如焦磷偏磷酸盐如HPPH可用于光动力疗法。 发现这些纳米晶体的药物效力与在体外和体内条件下在常规递送载体中配制的相同药物相当。

公开(公告)号：US20070086949A1

公开(公告)日：2007-04-19

申请号：US11471390

申请日：2006-06-20

申请人： Paras Prasad ,  Koichi Baba ,  Haridas Pudavar ,  Indrajit Roy ,  Tymish Ohulchanskyy ,  Hachiro Nakanishi ,  Akito Masuhara ,  Hitoshi Kasai

发明人： Paras Prasad ,  Koichi Baba ,  Haridas Pudavar ,  Indrajit Roy ,  Tymish Ohulchanskyy ,  Hachiro Nakanishi ,  Akito Masuhara ,  Hitoshi Kasai

IPC分类号： A61K49/00 ,  A61K31/555 ,  A61K31/4745 ,  A61K31/409

CPC分类号： A61K9/14 ,  A61K9/146 ,  A61K31/409 ,  A61K31/4745 ,  A61K31/555 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0067 ,  G01N33/5005 ,  G01N33/52

摘要： This invention provides nanocrystals or polymer doped nanocrystals of hydrophobic organic fluorescent dyes as stable dispersions in an aqueous system. The dispersions can be prepared without stabilizers such as surfactants and the like. The aqueous dispersions of the nanocrystals or the polymer doped nanocrystals can be used for bioimaging.

摘要翻译： 本发明提供疏水性有机荧光染料的纳米晶体或聚合物掺杂的纳米晶体作为水系统中的稳定分散体。 可以在没有稳定剂如表面活性剂等的情况下制备分散体。 纳米晶体或聚合物掺杂纳米晶体的水分散体可用于生物成像。

公开(公告)号：US07413341B1

公开(公告)日：2008-08-19

申请号：US11204605

申请日：2005-08-16

申请人： Aliaksandr Kachynski ,  Andrey Kuzmin ,  Haridas Pudavar ,  Paras N. Prasad

发明人： Aliaksandr Kachynski ,  Andrey Kuzmin ,  Haridas Pudavar ,  Paras N. Prasad

IPC分类号： G01K11/00

CPC分类号： G01K11/20 ,  G01K2213/00

摘要： A method of local temperature measurement in a sample is provided. The method comprises the stimulation, at a location in the sample, of anti-Stokes and Stokes emission from fluorophores which are present at the location in the sample, measuring the intensities of the stimulated radiation and calculating the temperature at the location from the measured intensities. The method can be used to obtain a thermal image of the sample.

摘要翻译： 提供了样品中局部温度测量的方法。 该方法包括在样品中的位置处刺激存在于样品中的位置处的来自荧光团的反斯托克斯和斯托克斯发射，测量受激辐射的强度并根据测量的强度计算该位置处的温度 。 该方法可用于获得样品的热图像。