公开(公告)号：US20070134340A1

公开(公告)日：2007-06-14

申请号：US11471075

申请日：2006-06-20

申请人： Paras Prasad ,  Haridas Pudavar ,  Koichi Baba ,  Indrajit Roy ,  Tymish Ohulchanskyy ,  Ravindra Pandey ,  Allan Oseroff

发明人： Paras Prasad ,  Haridas Pudavar ,  Koichi Baba ,  Indrajit Roy ,  Tymish Ohulchanskyy ,  Ravindra Pandey ,  Allan Oseroff

IPC分类号： A61K31/555 ,  A61K31/409 ,  A61K9/14

CPC分类号： A61K9/14 ,  A61K9/146 ,  A61K31/409 ,  A61K31/4745 ,  A61K31/555 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0067 ,  G01N33/5005 ,  G01N33/52

摘要： This invention provides nanocrystals or polymer doped nanocrystals of hydrophobic drug molecules as stably dispersed in an aqueous system which are prepared without stabilizers like surfactants and the like. In one embodiment, the drug is a tetra-pyrrole compound. An example is the hydrophobic photosensitizing anticancer drug 2-devinyl-2-(1-hexyloxyethyl)pyropheophorbide (HPPH). Pharmaceutical compositions comprising nanocrystals or polymer doped nanocrystals of hydrophobic drugs can be used for therapeutic purposes. For example pyropheophorbides such as HPPH can be used for photodynamic therapy. Drug efficacy of these nanocrystals were found to be comparable with that of same drug formulated in conventional delivery vehicles under in vitro and in vivo conditions.

摘要翻译： 本发明提供了稳定分散在水性体系中的疏水药物分子的纳米晶体或聚合物掺杂的纳米晶体，其不经过稳定剂如表面活性剂等制备。 在一个实施方案中，药物是四吡咯化合物。 一个例子是疏水性光敏抗癌药2-脱乙烯基-2-（1-己氧基乙基）焦脱镁叶绿素（HPPH）。 包含纳米晶体或疏水性药物的聚合物掺杂纳米晶体的药物组合物可用于治疗目的。 例如焦磷偏磷酸盐如HPPH可用于光动力疗法。 发现这些纳米晶体的药物效力与在体外和体内条件下在常规递送载体中配制的相同药物相当。

公开(公告)号：US20070086949A1

公开(公告)日：2007-04-19

申请号：US11471390

申请日：2006-06-20

申请人： Paras Prasad ,  Koichi Baba ,  Haridas Pudavar ,  Indrajit Roy ,  Tymish Ohulchanskyy ,  Hachiro Nakanishi ,  Akito Masuhara ,  Hitoshi Kasai

发明人： Paras Prasad ,  Koichi Baba ,  Haridas Pudavar ,  Indrajit Roy ,  Tymish Ohulchanskyy ,  Hachiro Nakanishi ,  Akito Masuhara ,  Hitoshi Kasai

IPC分类号： A61K49/00 ,  A61K31/555 ,  A61K31/4745 ,  A61K31/409

CPC分类号： A61K9/14 ,  A61K9/146 ,  A61K31/409 ,  A61K31/4745 ,  A61K31/555 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0067 ,  G01N33/5005 ,  G01N33/52

摘要： This invention provides nanocrystals or polymer doped nanocrystals of hydrophobic organic fluorescent dyes as stable dispersions in an aqueous system. The dispersions can be prepared without stabilizers such as surfactants and the like. The aqueous dispersions of the nanocrystals or the polymer doped nanocrystals can be used for bioimaging.

摘要翻译： 本发明提供疏水性有机荧光染料的纳米晶体或聚合物掺杂的纳米晶体作为水系统中的稳定分散体。 可以在没有稳定剂如表面活性剂等的情况下制备分散体。 纳米晶体或聚合物掺杂纳米晶体的水分散体可用于生物成像。

公开(公告)号：US20060088599A1

公开(公告)日：2006-04-27

申请号：US11195066

申请日：2005-08-02

申请人： Paras Prasad ,  Earl Bergey ,  Purnendu Dutta ,  Dhruba Bharali ,  Michal Stachowiak ,  Tymish Ohulchanskyy ,  Ilona Klejbor ,  Indrajit Roy

发明人： Paras Prasad ,  Earl Bergey ,  Purnendu Dutta ,  Dhruba Bharali ,  Michal Stachowiak ,  Tymish Ohulchanskyy ,  Ilona Klejbor ,  Indrajit Roy

IPC分类号： A61K48/00 ,  A61K9/50 ,  A61K9/16 ,  C12N15/87

CPC分类号： A61K9/5115 ,  A61K47/6923 ,  A61K47/6929 ,  A61K48/0025 ,  C12N15/88

摘要： Provided are amino functionalized ORMOSIL nanoparticles. Also provided are compositions comprising such particles and compositions in which the nanoparticles are complexed to polynucleotides. The complexing of polynucleotides to the amino functionalized ORMOSIL nanoparticles protects the polynucleotides from environmental damage. These complexes can be used for delivery of polynucleotides to cells.

摘要翻译： 提供氨基官能化的ORMOSIL纳米颗粒。 还提供了包含这样的颗粒和组合物的组合物，其中纳米颗粒与多核苷酸复合。 多核苷酸与氨基官能化的ORMOSIL纳米颗粒的复合保护多核苷酸免受环境破坏。 这些复合物可用于将多核苷酸递送至细胞。

公开(公告)号：US07364754B2

公开(公告)日：2008-04-29

申请号：US10764677

申请日：2004-01-26

申请人： Paras Prasad ,  Indrajit Roy ,  Earl J. Bergey ,  Tymish Y. Ohulchansky ,  Haridas Pudavar

发明人： Paras Prasad ,  Indrajit Roy ,  Earl J. Bergey ,  Tymish Y. Ohulchansky ,  Haridas Pudavar

IPC分类号： A61K9/14 ,  A61K31/57

CPC分类号： A61K9/5115 ,  A61K31/555 ,  A61K41/0057 ,  A61K41/0071 ,  B82Y5/00

摘要： The present invention provides methods and compositions for photodynamic therapy. The composition comprises ceramic nanoparticles in which a photosensitive drug/dye is entrapped. The ceramic nanoparticles are made by formation of a micellar composition of the dye. The ceramic material is added to the micellar composition and the ceramic nanoparticles are precipitated by alkaline hydrolysis. The precipitated nanoparticles in which the photosensitive dye/drug is entrapped can be isolated by dialysis. The resulting drug doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. Irradiation with light of suitable wavelength of the photosensitizing drug entrapped inside nanoparticles resulted in generation of singlet oxygen, which was able to diffuse out through the pores of the ceramic matrix. The drug loaded ceramic nanoparticles of the present invention can be used as drug carriers for photodynamic therapy.

摘要翻译： 本发明提供光动力疗法的方法和组合物。 该组合物包含其中包含光敏药物/染料的陶瓷纳米颗粒。 通过形成染料的胶束组合物制备陶瓷纳米颗粒。 将陶瓷材料加入到胶束组合物中，并通过碱水解沉淀陶瓷纳米颗粒。 可以通过透析分离感光性染料/药物被捕获的沉淀的纳米粒子。 所得药物掺杂的纳米颗粒是球形的，高度单分散的，并且在水性体系中稳定。 用纳米颗粒内的光敏药物的合适波长的光照射导致产生单线态氧，其能够通过陶瓷基质的孔扩散出来。 本发明的载药陶瓷纳米颗粒可用作光动力疗法的药物载体。

公开(公告)号：US20090114859A1

公开(公告)日：2009-05-07

申请号：US12140011

申请日：2008-06-16

申请人： Paras Prasad ,  Aliaksandr Kachynski ,  Andrey Kuzmin ,  Marcin Nyk ,  Indrajit Roy

发明人： Paras Prasad ,  Aliaksandr Kachynski ,  Andrey Kuzmin ,  Marcin Nyk ,  Indrajit Roy

IPC分类号： G01N23/04

CPC分类号： G01N33/588 ,  B82Y15/00

摘要： The present invention provides a method for imaging a biological specimen using non-linear optical properties of certain materials. The method comprises the steps of providing an aqueous dispersion of ZnO nanocrystals; contacting a biological specimen with an aqueous dispersion comprising ZnO nanocrystals; exposing the biological specimen to input electromagnetic radiation having a wavelength of from 600 to 1500 nm; recording the nonlinear output electromagnetic radiation; and generating an image of the biological specimen based on the nonlinear output radiation.

摘要翻译： 本发明提供一种使用某些材料的非线性光学性质对生物样本进行成像的方法。 该方法包括以下步骤：提供ZnO纳米晶体的水性分散体; 使生物样品与包含ZnO纳米晶体的水性分散体接触; 暴露生物样本以输入波长为600至1500nm的电磁辐射; 记录非线性输出电磁辐射; 以及基于所述非线性输出辐射生成所述生物样本的图像。

公开(公告)号：US08832050B2

公开(公告)日：2014-09-09

申请号：US13416603

申请日：2012-03-09

申请人： Nathan L. Binkert ,  Wojciech Golab ,  Indrajit Roy ,  Mehul A. Shah ,  Benjamin A. Sowell

发明人： Nathan L. Binkert ,  Wojciech Golab ,  Indrajit Roy ,  Mehul A. Shah ,  Benjamin A. Sowell

IPC分类号： G06F17/30

CPC分类号： G06F17/30961

摘要： A distributed balanced tree having a plurality of nodes distributed across a plurality of servers is accessed. Version information associated with a node of the distributed balanced tree is retrieved. Validity of a lookup transaction performed on the balanced tree is determined by verifying a version value of only the leaf node accessed during the lookup operation against the retrieved version information.

摘要翻译： 访问分布在多个服务器上的多个节点的分布式平衡树被访问。 检索与分布式平衡树的节点相关联的版本信息。 在平衡树上执行的查找事务的有效性是通过仅针对检索到的版本信息检查在查找操作期间访问的叶节点的版本值来确定的。

公开(公告)号：US20140033214A1

公开(公告)日：2014-01-30

申请号：US13562248

申请日：2012-07-30

申请人： Shivaram Venkataraman ,  Indrajit Roy ,  Mehul A. Shah ,  Robert Schreiber ,  Nathan Lorenzo Binkert ,  Parthasarathy Ranganathan

发明人： Shivaram Venkataraman ,  Indrajit Roy ,  Mehul A. Shah ,  Robert Schreiber ,  Nathan Lorenzo Binkert ,  Parthasarathy Ranganathan

IPC分类号： G06F9/46

CPC分类号： G06F9/5088 ,  G06F9/4881 ,  G06F9/5066

摘要： A plurality of array partitions are defined for use by a set of tasks of the program run-time. The array partitions can be determined from one or more arrays that are utilized by the program at run-time. Each of the plurality of computing devices are assigned to perform one or more tasks in the set of tasks. By assigning each of the plurality of computing devices to perform one or more tasks, an objective to reduce data transfer amongst the plurality of computing devices can be implemented.

摘要翻译： 定义多个阵列分区以供程序运行时的一组任务使用。 阵列分区可以从程序在运行时使用的一个或多个数组确定。 分配多个计算设备中的每一个以执行该组任务中的一个或多个任务。 通过分配多个计算设备中的每一个来执行一个或多个任务，可以实现减少多个计算设备之间的数据传输的目的。

公开(公告)号：US20130238576A1

公开(公告)日：2013-09-12

申请号：US13416603

申请日：2012-03-09

申请人： Nathan L. Binkert ,  Wojciech Golab ,  Indrajit Roy ,  Mehul A. Shah ,  Benjamin A. Sowell

发明人： Nathan L. Binkert ,  Wojciech Golab ,  Indrajit Roy ,  Mehul A. Shah ,  Benjamin A. Sowell

IPC分类号： G06F7/00

CPC分类号： G06F17/30961

摘要： A distributed balanced tree having a plurality of nodes distributed across a plurality of servers is accessed. Version information associated with a node of the distributed balanced tree is retrieved. Validity of a lookup transaction performed on the balanced tree is determined by verifying a version value of only the leaf node accessed during the lookup operation against the retrieved version information.

摘要翻译： 访问分布在多个服务器上的多个节点的分布式平衡树被访问。 检索与分布式平衡树的节点相关联的版本信息。 在平衡树上执行的查找事务的有效性是通过仅针对检索到的版本信息检查在查找操作期间访问的叶节点的版本值来确定的。

公开(公告)号：US09690679B2

公开(公告)日：2017-06-27

申请号：US13285884

申请日：2011-10-31

申请人： Mehul A. Shah ,  Wojciech Golab ,  Indrajit Roy ,  Nathan Lorenzo Binkert ,  Stavros Harizopoulos

发明人： Mehul A. Shah ,  Wojciech Golab ,  Indrajit Roy ,  Nathan Lorenzo Binkert ,  Stavros Harizopoulos

IPC分类号： G06F17/30 ,  G06F11/20 ,  G06F11/16 ,  G06F11/18 ,  G06Q10/10 ,  G06F11/14

CPC分类号： G06F11/2035 ,  G06F11/1425 ,  G06F11/1474 ,  G06F11/1658 ,  G06F11/1666 ,  G06F11/183 ,  G06F11/2023 ,  G06Q10/10

摘要： An embodiment provides a system and method for transaction commitment and replication. The method includes receiving a minitransaction from a client node at one or more memory nodes, wherein each memory node includes a number of replicas. The minitransaction is a type of transaction which atomically executes any combination of reading, comparing, and writing to any of a number of memory locations. The method also includes determining, for a leader of the replicas within a memory node, whether the leader is able to commit the minitransaction and stabilizing state changes of the minitransaction within a transaction log using a consensus procedure to update the replicas. The method further includes committing the minitransaction if, at each memory node, a quorum of the replicas is able to stabilize the minitransaction, or aborting the minitransaction otherwise.

公开(公告)号：US08938599B2

公开(公告)日：2015-01-20

申请号：US13421651

申请日：2012-03-15

申请人： Michael Mihn-Jong Lee ,  Indrajit Roy ,  Vanish Talwar ,  Alvin AuYoung ,  Parthasarathy Ranganathan

发明人： Michael Mihn-Jong Lee ,  Indrajit Roy ,  Vanish Talwar ,  Alvin AuYoung ,  Parthasarathy Ranganathan

IPC分类号： G06F12/02

CPC分类号： G06F12/0284

摘要： In a method of implementing a graph storage system, the graph storage system is stored on a plurality of computing systems. A global address space is provided for distributed graph storage. The global address space is managed with graph allocators, in which a graph allocator allocates space from a block of the distributed global memory in order to store a plurality of graphs.

摘要翻译： 在实现图形存储系统的方法中，图形存储系统被存储在多个计算系统上。 为分布式图形存储提供了全局地址空间。 全局地址空间由图形分配器管理，其中图形分配器从分布式全局存储器的块分配空间以存储多个图形。