公开(公告)号：US07781464B2

公开(公告)日：2010-08-24

申请号：US11359657

申请日：2006-02-21

申请人： Partha Neogi ,  Bishwajit Nag ,  Debendranath Dey ,  Abhijeet Nag ,  Birendra Kumar Bhattacharya ,  Vinod Kumar Singh ,  Surendradoss Jayakumar

发明人： Partha Neogi ,  Bishwajit Nag ,  Debendranath Dey ,  Abhijeet Nag ,  Birendra Kumar Bhattacharya ,  Vinod Kumar Singh ,  Surendradoss Jayakumar

IPC分类号： A61K31/426 ,  C07D277/04

CPC分类号： C07D277/34 ,  C07D209/34 ,  C07D277/36 ,  C07D401/12 ,  C07D417/12

摘要： The present invention relates to novel heterocyclic diphenyl ether and diphenyl amine compounds, derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof and pharmaceutically acceptable compositions containing these singly or in combination. The compounds of the present invention are effective in lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels and are useful in the treatment and/or prophylaxis of diabetes. The compounds of the present invention are effective in treatment of obesity, inflammation, autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and immunological diseases, including the treatment of cancer. Furthermore, the compounds are useful for the treatment of disorders associated with insulin resistance.

摘要翻译： 本发明涉及新颖的杂环二苯醚和二苯胺化合物，衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂化物，药学上可接受的盐和药学上可接受的溶剂合物以及含有这些单独或组合的药学上可接受的组合物。 本发明的化合物可有效降低血糖，血清胰岛素，游离脂肪酸，胆固醇和甘油三酯水平，并且可用于治疗和/或预防糖尿病。 本发明的化合物可有效治疗肥胖，炎症，自身免疫性疾病如多发性硬化和类风湿性关节炎以及免疫疾病，包括治疗癌症。 此外，这些化合物可用于治疗与胰岛素抵抗相关的疾病。

公开(公告)号：US20060247285A1

公开(公告)日：2006-11-02

申请号：US11359657

申请日：2006-02-21

申请人： Partha Neogi ,  Bishwajit Nag ,  Debendranath Dey ,  Abhijeet Nag ,  Birendra Bhattacharya ,  Vinod Singh ,  Surendradoss Jayakumar

发明人： Partha Neogi ,  Bishwajit Nag ,  Debendranath Dey ,  Abhijeet Nag ,  Birendra Bhattacharya ,  Vinod Singh ,  Surendradoss Jayakumar

IPC分类号： A61K31/426 ,  C07D277/24

CPC分类号： C07D277/34 ,  C07D209/34 ,  C07D277/36 ,  C07D401/12 ,  C07D417/12

摘要： The present invention relates to novel heterocyclic diphenyl ether and diphenyl amine compounds, derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof and pharmaceutically acceptable compositions containing these singly or in combination. The compounds of the present invention are effective in lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels and are useful in the treatment and/or prophylaxis of diabetes. The compounds of the present invention are effective in treatment of obesity, inflammation, autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and immunological diseases, including the treatment of cancer. Furthermore, the compounds are useful for the treatment of disorders associated with insulin resistance.

摘要翻译： 本发明涉及新颖的杂环二苯醚和二苯胺化合物，衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂化物，药学上可接受的盐和药学上可接受的溶剂合物以及含有这些单独或组合的药学上可接受的组合物。 本发明的化合物可有效降低血糖，血清胰岛素，游离脂肪酸，胆固醇和甘油三酯水平，并且可用于治疗和/或预防糖尿病。 本发明的化合物可有效治疗肥胖，炎症，自身免疫性疾病如多发性硬化和类风湿性关节炎以及免疫疾病，包括治疗癌症。 此外，这些化合物可用于治疗与胰岛素抵抗相关的疾病。