公开(公告)号：US20150297751A1

公开(公告)日：2015-10-22

申请号：US14438655

申请日：2013-10-29

申请人： Particle Sciences, Inc.

发明人： Mark Mitchnick ,  Garry Gwozdz ,  Andrew Loxley

IPC分类号： A61K47/48 ,  A61K9/16

CPC分类号： A61K47/6835 ,  A61K9/1617 ,  A61K47/6937

摘要： A targeted drug delivery complex containing a particle, a targeting moiety electrostatically attached to the particle, and an active pharmaceutical ingredient attached to or dispersed or dissolved within the particle is provided. Also provided are pharmaceutical formulations containing a plurality of the complexes as well as methods for use in targeting an active pharmaceutical ingredient to a selected cell or tissue and production of such formulations.

摘要翻译： 提供了含有颗粒，静电连接到颗粒上的靶向部分和附着于或分散或溶解在颗粒内的活性药物成分的靶向药物递送复合物。 还提供了含有多种复合物的药物制剂以及用于将活性药物成分靶向所选择的细胞或组织以及制备这些制剂的方法。

公开(公告)号：US10888625B2

公开(公告)日：2021-01-12

申请号：US14438655

申请日：2013-10-29

申请人： Particle Sciences, Inc.

发明人： Mark Mitchnick ,  Garry Gwozdz ,  Andrew Loxley

IPC分类号： A61K35/00 ,  A61K47/68 ,  A61K9/16 ,  A61K47/69

摘要： A targeted drug delivery complex containing a particle, a targeting moiety electrostatically attached to the particle, and an active pharmaceutical ingredient attached to or dispersed or dissolved within the particle is provided. Also provided are pharmaceutical formulations containing a plurality of the complexes as well as methods for use in targeting an active pharmaceutical ingredient to a selected cell or tissue and production of such formulations.

公开(公告)号：US20160000905A1

公开(公告)日：2016-01-07

申请号：US14770284

申请日：2014-02-24

申请人： Particle Sciences, Inc.

发明人： Mark Mitchnick ,  Andrew Loxley ,  Garry Thomas Gwozdz

IPC分类号： A61K39/385 ,  A61K9/107

CPC分类号： A61K39/385 ,  A61K9/107 ,  A61K9/1075 ,  A61K39/39 ,  A61K47/186 ,  A61K47/44 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6018

摘要： Compositions of one or more TLR agonists and one or more antigens adsorbed or attached to the same particles or to different particles are provided. Also provided are methods for producing and using these compositions.

摘要翻译： 提供一种或多种TLR激动剂和吸附或附着于相同颗粒或不同颗粒的一种或多种抗原的组合物。 还提供了用于生产和使用这些组合物的方法。